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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ightm1Kplm
targeted mutation 1, Kong-Peng Lam
MGI:3692558
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Ightm1Kplm/Igh+ involves: A/WySnJ * BALB/c MGI:3692976
ht2
 		Ightm1Kplm/Igh+ Not Specified MGI:3693005
ht3
 		Ightm1Kplm/Ightm4Cgn involves: 129P2/OlaHsd MGI:3693008
ht4
 		Ightm1Kplm/Ightm3Cgn involves: C57BL/6 MGI:3693007
cx5
 		Ightm1Kplm/Ightm4Cgn
Tg(Igk-V4CH27)1-2Shc/0 		involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:3693009
cx6
 		Ightm1Kplm/Igh+
Tg(Igk-V4CH27)1-2Shc/0 		involves: C57BL/6 * SJL MGI:3693010


Genotype
MGI:3692976
ht1
Allelic
Composition		 Ightm1Kplm/Igh+
Genetic
Background		 involves: A/WySnJ * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm1Kplm mutation (0 available); any Igh mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal B-1 B cell morphology ( J:115788 )
• Tnfsf13b treatment does not stimulate proliferation of activated B-1 cells in culture
• expression of CD21/CD35 on B-1 cells from mutants is decreased compared to wild-type

immune system
abnormal B-1 B cell morphology ( J:115788 )
• Tnfsf13b treatment does not stimulate proliferation of activated B-1 cells in culture
• expression of CD21/CD35 on B-1 cells from mutants is decreased compared to wild-type




Genotype
MGI:3693005
ht2
Allelic
Composition		 Ightm1Kplm/Igh+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm1Kplm mutation (0 available); any Igh mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal B cell differentiation ( J:115292 )
• mice produce predominantly B-1 cells which express intermediate levels of CD5, low levels of B220 and IgD, and no detectable CD23
increased B cell number ( J:115292 )
• in 2-4 month old mice, B cell number in the spleen is increased 2-fold and 20-fold in peritoneal cavity compared to wild-type

immune system
abnormal B cell differentiation ( J:115292 )
• mice produce predominantly B-1 cells which express intermediate levels of CD5, low levels of B220 and IgD, and no detectable CD23
increased B cell number ( J:115292 )
• in 2-4 month old mice, B cell number in the spleen is increased 2-fold and 20-fold in peritoneal cavity compared to wild-type




Genotype
MGI:3693008
ht3
Allelic
Composition		 Ightm1Kplm/Ightm4Cgn
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm1Kplm mutation (0 available); any Igh mutation (43 available)
Ightm4Cgn mutation (0 available); any Igh mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal B cell differentiation ( J:115292 )
• in 2-4 month old mice, B cells in these mice express high levels of B220 and IgD, and the majority are CD23-positive, while CD5 is not expressed, indicating that these cells are B-2 cells
abnormal B cell number ( J:115292 )
• splenic B cell number is similar to that found in wild-type and single Ightm3Cgn or Ightm4Cgn mutants, but peritoneal B cell number is increased, similar to Ightm1Kplm mutants
abnormal B-1 B cell morphology ( J:115292 )
• B cells expressing only Ightm1Kplm (indicating loss of the Ightm4Cgn allele) are phenotypically B-1 cells

immune system
abnormal B cell differentiation ( J:115292 )
• in 2-4 month old mice, B cells in these mice express high levels of B220 and IgD, and the majority are CD23-positive, while CD5 is not expressed, indicating that these cells are B-2 cells
abnormal B cell number ( J:115292 )
• splenic B cell number is similar to that found in wild-type and single Ightm3Cgn or Ightm4Cgn mutants, but peritoneal B cell number is increased, similar to Ightm1Kplm mutants
abnormal B-1 B cell morphology ( J:115292 )
• B cells expressing only Ightm1Kplm (indicating loss of the Ightm4Cgn allele) are phenotypically B-1 cells




Genotype
MGI:3693007
ht4
Allelic
Composition		 Ightm1Kplm/Ightm3Cgn
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm1Kplm mutation (0 available); any Igh mutation (43 available)
Ightm3Cgn mutation (0 available); any Igh mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal B cell differentiation ( J:115292 )
• in 2-4 month old mice, majority are CD23-positive, while CD5 is not expressed, indicating that these cells are B-2 cells
abnormal B cell number ( J:115292 )
• in 2-4 month old mice, splenic B cell number is similar to that found in wild-type and single Ightm3Cgn or Ightm4Cgnmutants, but peritoneal B cell number is increased, similar to Ightm1Kplm mutants

immune system
abnormal B cell differentiation ( J:115292 )
• in 2-4 month old mice, majority are CD23-positive, while CD5 is not expressed, indicating that these cells are B-2 cells
abnormal B cell number ( J:115292 )
• in 2-4 month old mice, splenic B cell number is similar to that found in wild-type and single Ightm3Cgn or Ightm4Cgnmutants, but peritoneal B cell number is increased, similar to Ightm1Kplm mutants




Genotype
MGI:3693009
cx5
Allelic
Composition		 Ightm1Kplm/Ightm4Cgn
Tg(Igk-V4CH27)1-2Shc/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm1Kplm mutation (0 available); any Igh mutation (43 available)
Ightm4Cgn mutation (0 available); any Igh mutation (43 available)
Tg(Igk-V4CH27)1-2Shc mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased B cell number ( J:115292 )
• splenic B cell number is increased 3- to 5-fold compared to Tg(Igk-V4CH27)1-2Shc or Ightm4Cgn, Tg(Igk-V4CH27)1-2Shc mutants

immune system
increased B cell number ( J:115292 )
• splenic B cell number is increased 3- to 5-fold compared to Tg(Igk-V4CH27)1-2Shc or Ightm4Cgn, Tg(Igk-V4CH27)1-2Shc mutants




Genotype
MGI:3693010
cx6
Allelic
Composition		 Ightm1Kplm/Igh+
Tg(Igk-V4CH27)1-2Shc/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm1Kplm mutation (0 available); any Igh mutation (43 available)
Tg(Igk-V4CH27)1-2Shc mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased B cell number ( J:115292 )
• mice have 2-fold more splenic B cells than Ightm1Kplm mutants and 8-fold more cells than Tg(Igk-V4CH27)1-2Shc or Ightm4Cgn, Tg(Igk-V4CH27)1-2Shc mutants

immune system
increased B cell number ( J:115292 )
• mice have 2-fold more splenic B cells than Ightm1Kplm mutants and 8-fold more cells than Tg(Igk-V4CH27)1-2Shc or Ightm4Cgn, Tg(Igk-V4CH27)1-2Shc mutants




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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory