All Phenotypes Mog<tm1(cre)Gkl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mog^tm1(cre)Gkl
targeted mutation 1, George Kollias
MGI:3689957

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1(HA)Libl/Gt(ROSA)26Sor^tm1(HA)Libl Mog^tm1(cre)Gkl/? Tg(TcraCl4,TcrbCl4)1Shrm/0	involves: 129/Sv * BALB/c * C57BL/6	MGI:3805339
cn2	Gt(ROSA)26Sor^tm1(HA)Libl/Gt(ROSA)26Sor^tm1(HA)Libl Mog^tm1(cre)Gkl/?	involves: 129/Sv * C57BL/6	MGI:3805338
cn3	Fas^tm1Cgn/Fas^tm1Cgn Mog^tm1(cre)Gkl/Mog⁺ Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak	involves: 129S2/SvPas * C57BL/6	MGI:3690542
cn4	Fas^tm1Cgn/Fas^tm1Cgn Mog^tm1(cre)Gkl/Mog⁺	involves: C57BL/6	MGI:3690541
cn5	Gt(ROSA)26Sor^{tm1(HBEGF)Awai}/Gt(ROSA)26Sor^{tm1(HBEGF)Awai} Mog^tm1(cre)Gkl/?	involves: C57BL/6	MGI:3772815
cn6	Fadd^tm1Mpa/Fadd^tm1Mpa Mog^tm1(cre)Gkl/Mog⁺	involves: C57BL/6 * SJL	MGI:4880724
cx7	Mog^tm1(cre)Gkl/Mog^tm1(cre)Gkl Tg(Tcra2D2,Tcrb2D2)1Kuch/0	C57BL/6-Mog^tm1(cre)Gkl Tg(Tcra2D2,Tcrb2D2)1Kuch	MGI:4461061

Allelic Composition	Gt(ROSA)26Sor^tm1(HA)Libl/Gt(ROSA)26Sor^tm1(HA)Libl Mog^tm1(cre)Gkl/? Tg(TcraCl4,TcrbCl4)1Shrm/0
Genetic Background	involves: 129/Sv * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1(HA)Libl mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Mog^tm1(cre)Gkl mutation (1 available); any Mog mutation (58 available)
Tg(TcraCl4,TcrbCl4)1Shrm mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

weight loss ( J:137838 )

• 4 weeks after receiving transfer of HA-specific effector CD8 T cells, mice exhibit weight loss

behavior/neurological

impaired righting response ( J:137838 )

• 4 weeks after receiving transfer of HA-specific effector CD8 T cells, severely affected animals display difficulty to right themselves when overturned

tremors ( J:137838 )

• 4 weeks after receiving transfer of HA-specific effector CD8 T cells (Tc1 cells), severely affected animals exhibit tremors

decreased locomotor activity ( J:137838 )

• 4 weeks after receiving transfer of HA-specific effector CD8 T cells, severely affected animals show reduced mobility

nervous system

brain inflammation ( J:137838 )

• inflammation is also observed frequently in cerebellum, fornix and periventricular areas

spinal cord inflammation ( J:137838 )

• by 5 days following transfer of Tc1 cells, all mutants examined show spinal cord inflammation

• T cell infiltration into spinal cord starts on day 5 after transfer and peaks at day 28

optic nerve inflammation ( J:137838 )

• by 5 days following transfer of Tc1 cells, all mutants examined show optic nerve inflammation

abnormal oligodendrocyte morphology ( J:137838 )

• apoptosis in optic nerve and spinal cord is seen at early time points following Tc1 transfer

abnormal optic nerve morphology ( J:137838 )

• focal areas with reduced myelin density and thin myelin sheaths are observed in animals after transfer of Tc1 cells

• vacuolization is seen at day 5 after Tc1 cell transfer

demyelination ( J:137838 )

• by 5 days following transfer of Tc1 cells, demyelination is observed in the spinal cord and optic nerve

• from 9 days post-transfer, most mutants exhibit extensive demyelination in optic nerves

• by day 19, actively demyelinating lesions show severe axonal damage

vision/eye

abnormal optic nerve morphology ( J:137838 )

• focal areas with reduced myelin density and thin myelin sheaths are observed in animals after transfer of Tc1 cells

• vacuolization is seen at day 5 after Tc1 cell transfer

immune system

brain inflammation ( J:137838 )

• inflammation is also observed frequently in cerebellum, fornix and periventricular areas

spinal cord inflammation ( J:137838 )

• by 5 days following transfer of Tc1 cells, all mutants examined show spinal cord inflammation

• T cell infiltration into spinal cord starts on day 5 after transfer and peaks at day 28

optic nerve inflammation ( J:137838 )

• by 5 days following transfer of Tc1 cells, all mutants examined show optic nerve inflammation

Allelic Composition	Gt(ROSA)26Sor^tm1(HA)Libl/Gt(ROSA)26Sor^tm1(HA)Libl Mog^tm1(cre)Gkl/?
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:137838 )

N	• mutants do not show neurological signs when followed for up to 9 months of age

immune system

immune system phenotype ( J:137838 )

N	• no deletion of HA-specific CD8 T cells is observed

Allelic Composition	Fas^tm1Cgn/Fas^tm1Cgn Mog^tm1(cre)Gkl/Mog⁺ Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fas^tm1Cgn mutation (1 available); any Fas mutation (82 available)
Mog^tm1(cre)Gkl mutation (1 available); any Mog mutation (58 available)
Tnfrsf1a^tm1Mak mutation (2 available); any Tnfrsf1a mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:114741 )

N	• B and T cell distribution in the lymph nodes is normal • the fraction of B220+ T cells in the lymph nodes and the thymic distribution of CD4/CD8 cells are similar to wild-type

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:114741 )

• mice are almost completely resistant to induction of experimental autoimmune encephalomyelitis (EAE) by injection of MOG p35-55

• almost no oligodendrocyte apoptosis after EAE induction unlike in wild-type mice

• reduction in demyelination and inflammation after induction of EAE is greater than in mutant mice wild-type for Tnfrsf1a

• 24 days after induction of EAE, minimal axonal injury is seen in spinal cords

Allelic Composition	Fas^tm1Cgn/Fas^tm1Cgn Mog^tm1(cre)Gkl/Mog⁺
Genetic Background	involves: C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:114741 )

N	• the fraction of B220+ T cells in the lymph nodes and the thymic distribution of CD4/CD8 cells are similar to wild-type

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:114741 )

• reduction in the onset and severity, but not incidence, of experimental autoimmune encephalomyelitis (EAE) induced by injection of MOG p35-55

• demyelination induced by injection of MOG p35-55 is reduced by about 70% compared to wild-type

• perivascular and parenchymal infiltration by T lymphocytes and macrophages is also reduced after induction of EAE

• mild reduction in oligodendrocyte apoptosis after EAE induction

Allelic Composition	Gt(ROSA)26Sor^{tm1(HBEGF)Awai}/Gt(ROSA)26Sor^{tm1(HBEGF)Awai} Mog^tm1(cre)Gkl/?
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(HBEGF)Awai} mutation (4 available); any Gt(ROSA)26Sor mutation (942 available)
Mog^tm1(cre)Gkl mutation (1 available); any Mog mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

weight loss ( J:131076 )

• after intaperitoneal injection with diptheria toxin 3 times daily for 7 days, mice present with weight loss after ~30 days

behavior/neurological

tremors ( J:131076 )

• after intaperitoneal injection with diptheria toxin 3 times daily for 7 days, mice present with tremor after ~30 days

hindlimb paralysis ( J:131076 )

• after intaperitoneal injection with diptheria toxin 3 times daily for 7 days, mice present with hindlimb paralysis after ~30 days

nervous system

increased neuron apoptosis ( J:131076 )

• 3 days following diptheria toxin injection 3 times daily for 7 days, substantial apoptosis is detected in the granular layer of the cerebella of double mutants; cells are likely oligodendrocytes, but may be granule cells

astrocytosis ( J:131076 )

• reactive astrogliosis is observed, as well as inflammatory cells, in oligodendrocytes after diptheria toxin injection 3 times daily for 7 days

abnormal neuron morphology ( J:131076 )

• after intaperitoneal injection with diptheria toxin 3 times daily for 7 days, severe destruction of myelinated structures throughout the CNS is observed

demyelination ( J:131076 )

• diptheria toxin-induced demyelination is observed in treated double mutants

immune system

abnormal immune system physiology ( J:131076 )

• after diptheria toxin treatment for 7 days, low titers of IgM diptheria toxin-specific antibodies are detected in the serum; DT-specific IgG1 antibodies are detected later, and amounts are ~50-fold lower than in a typical hapten-induced antiboby response

cellular

increased neuron apoptosis ( J:131076 )

Allelic Composition	Fadd^tm1Mpa/Fadd^tm1Mpa Mog^tm1(cre)Gkl/Mog⁺
Genetic Background	involves: C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fadd^tm1Mpa mutation (0 available); any Fadd mutation (19 available)
Mog^tm1(cre)Gkl mutation (1 available); any Mog mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:167475 )

N	• peripheral T cell activation is normal

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:167475 )

• MOG35-55-treated mice exhibit less severe disease and reduced oligodendrocyte apoptosis compared with similarly treated wild-type mice

• however, MOG35-55-treated mice exhibit normal T cell activation

nervous system

nervous system phenotype ( J:167475 )

N	• mice exhibit normal myelination

abnormal oligodendrocyte apoptosis ( J:167475 )

• oligodendrocytes are completely resistant to TNF-induced apoptosis unlike wild-type mice

• MOG35-55-treated mice exhibit less oligodendrocyte apoptosis compared to in similarly treated wild-type mice

cellular

abnormal oligodendrocyte apoptosis ( J:167475 )

• oligodendrocytes are completely resistant to TNF-induced apoptosis unlike wild-type mice

• MOG35-55-treated mice exhibit less oligodendrocyte apoptosis compared to in similarly treated wild-type mice

Allelic Composition	Mog^tm1(cre)Gkl/Mog^tm1(cre)Gkl Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic Background	C57BL/6-Mog^tm1(cre)Gkl Tg(Tcra2D2,Tcrb2D2)1Kuch

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mog^tm1(cre)Gkl mutation (1 available); any Mog mutation (58 available)
Tg(Tcra2D2,Tcrb2D2)1Kuch mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to experimental autoimmune encephalomyelitis ( J:151335 )

• between 15% and 20% of mice develop spontaneous EAE

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
multiple sclerosis		DOID:2377	OMIM:612594 OMIM:612595 OMIM:612596	J:151335

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