All Phenotypes Igk<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Igk⁺
wild type
MGI:3689730

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	\Igk^tm1Mss/\Igk⁺	involves: 129S4/SvJae	MGI:3829708
cx2	\Igh^tm2Rsky/\Igh⁺ \Igk^tm1Rsky/\Igk⁺	either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * BALB/c)	MGI:3689731
cx3	\Igh^tm2Rsky/\Igh⁺ \Igk^tm2Rsky/\Igk⁺	either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * BALB/c)	MGI:3689732
cx4	\Igh^tm2Cgn/\Igh⁺ \Igk^tm1Rsky/\Igk⁺	either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * BALB/c)	MGI:3689733
cx5	\Blnk^tm1Kplm/\Blnk^tm1Kplm \Igh^tm4Cgn/\Igh⁺ \Igk^tm1Rsky/\Igk⁺	involves: 129P2/OlaHsd	MGI:3844072
cx6	\Igh^tm2Cgn/\Igh⁺ \Igk^tm2Rsky/\Igk⁺	involves: 129P2/OlaHsd	MGI:3851175
cx7	\Igk^tm1Rsky/\Igk⁺ \Igll1^tm1Cgn/\Igll1^tm1Cgn	involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6	MGI:3689735
cx8	\Igh^tm2Cgn/\Igh⁺ \Igk^tm2Rsky/\Igk⁺ \Prkdc^scid/\Prkdc^scid	involves: 129P2/OlaHsd * BALB/c * C57BL/Ka	MGI:3851176
cx9	\Ggta1^tm1Jbl/\Ggta1⁺ \Igh^tm1Jiac/\Igh^tm1Jiac \Igk^tm1Jiac/\Igk⁺	involves: 129S2/SvPas * 129S4/SvJae * C57BL/6	MGI:3779041

Allelic Composition	\Igk^tm1Mss/\Igk⁺
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igk^tm1Mss mutation (0 available); any Igk mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:143876 )

• mice are healthy, viable and have normal number of immune cells

• presence of YFP cassette does not interfere with recombination of the Igk locus

Allelic Composition	\Igh^tm2Rsky/\Igh⁺ \Igk^tm1Rsky/\Igk⁺
Genetic Background	either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * BALB/c)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh^tm2Rsky mutation (2 available); any Igh mutation (41 available)
Igk^tm1Rsky mutation (1 available); any Igk mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell differentiation ( J:111431 )

• lack 3-83Ig+ mature B cells, although on an H2^d background some 3-83Ig+ immature B cells are detected in the bone marrow

• about and 8-fold and 15-fold increase in the frequency and absolute number of lambda expressing splenic B cells, respectively, compared to wild-type mice

• however, total B cell numbers are similar to wild-type

hematopoietic system

abnormal B cell differentiation ( J:111431 )

• lack 3-83Ig+ mature B cells, although on an H2^d background some 3-83Ig+ immature B cells are detected in the bone marrow

• about and 8-fold and 15-fold increase in the frequency and absolute number of lambda expressing splenic B cells, respectively, compared to wild-type mice

• however, total B cell numbers are similar to wild-type

Allelic Composition	\Igh^tm2Rsky/\Igh⁺ \Igk^tm2Rsky/\Igk⁺
Genetic Background	either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * BALB/c)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh^tm2Rsky mutation (2 available); any Igh mutation (41 available)
Igk^tm2Rsky mutation (1 available); any Igk mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell differentiation ( J:111431 )

• lack 3-83Ig+ mature B cells, although on an H2^d background some 3-83Ig+ immature B cells are detected in the bone marrow

hematopoietic system

abnormal B cell differentiation ( J:111431 )

• lack 3-83Ig+ mature B cells, although on an H2^d background some 3-83Ig+ immature B cells are detected in the bone marrow

Allelic Composition	\Igh^tm2Cgn/\Igh⁺ \Igk^tm1Rsky/\Igk⁺
Genetic Background	either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * BALB/c)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh^tm2Cgn mutation (1 available); any Igh mutation (41 available)
Igk^tm1Rsky mutation (1 available); any Igk mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell differentiation ( J:111431 )

• about 90% of B cells are positive for the B1-8 heavy chain

absent pre-B cells ( J:111431 )

• the CD43- sIgM- pre B cell compartment is virtually absent

hematopoietic system

abnormal B cell differentiation ( J:111431 )

• about 90% of B cells are positive for the B1-8 heavy chain

absent pre-B cells ( J:111431 )

• the CD43- sIgM- pre B cell compartment is virtually absent

Allelic Composition	\Blnk^tm1Kplm/\Blnk^tm1Kplm \Igh^tm4Cgn/\Igh⁺ \Igk^tm1Rsky/\Igk⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Blnk^tm1Kplm mutation (0 available); any Blnk mutation (76 available)
Igh^tm4Cgn mutation (0 available); any Igh mutation (41 available)
Igk^tm1Rsky mutation (1 available); any Igk mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell differentiation ( J:120460 )

• innocuous transgenic BCR on Blnk null B cells leads to enhanced development of these B cells compared to Blnk homozygotes

• two populations are detected in the bone marrow consisting of IgM^lo and IgM^hi groups

• both populations appear to be immature B cells as they have low surface level expression of MHC-II and CD43, and high levels of CD24

• based on intensity of these surface markers, the IgM^lo population is the less mature of the two

• in vitro maturation of bone marrow cells demonstrate delayed development of these IgM⁺ cells

• B cells in the periphery are primarily T1 stage B cells that have a short half-life

increased transitional stage B cell number ( J:120460 )

• B cells in the periphery are primarily T1 stage B cells

decreased B cell number ( J:120460 )

• B cell numbers are decreased 2- to 3- fold in the spleen

• the B cells present are primarily T1 stage B cells

increased pre-B cell number ( J:120460 )

• pre-B cell numbers are 2-3 fold higher in the bone marrow than in transgenic controls

hematopoietic system

abnormal B cell differentiation ( J:120460 )

• innocuous transgenic BCR on Blnk null B cells leads to enhanced development of these B cells compared to Blnk homozygotes

• two populations are detected in the bone marrow consisting of IgM^lo and IgM^hi groups

• both populations appear to be immature B cells as they have low surface level expression of MHC-II and CD43, and high levels of CD24

• based on intensity of these surface markers, the IgM^lo population is the less mature of the two

• in vitro maturation of bone marrow cells demonstrate delayed development of these IgM⁺ cells

• B cells in the periphery are primarily T1 stage B cells that have a short half-life

increased transitional stage B cell number ( J:120460 )

• B cells in the periphery are primarily T1 stage B cells

decreased B cell number ( J:120460 )

• B cell numbers are decreased 2- to 3- fold in the spleen

• the B cells present are primarily T1 stage B cells

increased pre-B cell number ( J:120460 )

• pre-B cell numbers are 2-3 fold higher in the bone marrow than in transgenic controls

Allelic Composition	\Igh^tm2Cgn/\Igh⁺ \Igk^tm2Rsky/\Igk⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh^tm2Cgn mutation (1 available); any Igh mutation (41 available)
Igk^tm2Rsky mutation (1 available); any Igk mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal class switch recombination ( J:150435 )

• B cells have about a 2-fold increase in class switch recombination to IgG1

immune system

abnormal class switch recombination ( J:150435 )

• B cells have about a 2-fold increase in class switch recombination to IgG1

Allelic Composition	\Igk^tm1Rsky/\Igk⁺ \Igll1^tm1Cgn/\Igll1^tm1Cgn
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igk^tm1Rsky mutation (1 available); any Igk mutation (28 available)
Igll1^tm1Cgn mutation (1 available); any Igll1 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell differentiation ( J:35357 )

• only 5.5% of CD43+ B cell progenitors express the kappa chain in the cytoplasm compared to 22% of wild-type cells at a similar developmental stage which express a kappa chain

decreased immature B cell number ( J:35357 )

• about a 5-fold reduction in immature B cell numbers compared to wild-type mice, but a 3-fold increase compared to Igll1 mutant mice wild-type at the Igk locus

decreased B cell number ( J:35357 )

• about a 5-fold reduction in mature and immature B cell numbers compared to wild-type mice, but a 3-fold increase compared to Igll1 mutant mice wild-type at the Igk locus

• in the spleen at 6 - 12 weeks of age, B cell numbers are about 1/3 that of wild-type mice

decreased mature B cell number ( J:35357 )

• about a 5-fold reduction in mature B cell numbers compared to wild-type mice, but a 3-fold increase compared to Igll1 mutant mice wild-type at the Igk locus

decreased pre-B cell number ( J:35357 )

• about a 3-fold reduction compared to wild-type mice

hematopoietic system

abnormal B cell differentiation ( J:35357 )

• only 5.5% of CD43+ B cell progenitors express the kappa chain in the cytoplasm compared to 22% of wild-type cells at a similar developmental stage which express a kappa chain

decreased immature B cell number ( J:35357 )

• about a 5-fold reduction in immature B cell numbers compared to wild-type mice, but a 3-fold increase compared to Igll1 mutant mice wild-type at the Igk locus

decreased B cell number ( J:35357 )

• about a 5-fold reduction in mature and immature B cell numbers compared to wild-type mice, but a 3-fold increase compared to Igll1 mutant mice wild-type at the Igk locus

• in the spleen at 6 - 12 weeks of age, B cell numbers are about 1/3 that of wild-type mice

decreased mature B cell number ( J:35357 )

• about a 5-fold reduction in mature B cell numbers compared to wild-type mice, but a 3-fold increase compared to Igll1 mutant mice wild-type at the Igk locus

decreased pre-B cell number ( J:35357 )

• about a 3-fold reduction compared to wild-type mice

Allelic Composition	\Igh^tm2Cgn/\Igh⁺ \Igk^tm2Rsky/\Igk⁺ \Prkdc^scid/\Prkdc^scid
Genetic Background	involves: 129P2/OlaHsd * BALB/c * C57BL/Ka

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal class switch recombination ( J:150435 )

• B cells show defects in CSR to IgG1 and IgG3 ranging from 30%?70% of controls

immune system

abnormal class switch recombination ( J:150435 )

• B cells show defects in CSR to IgG1 and IgG3 ranging from 30%?70% of controls

Allelic Composition	\Ggta1^tm1Jbl/\Ggta1⁺ \Igh^tm1Jiac/\Igh^tm1Jiac \Igk^tm1Jiac/\Igk⁺
Genetic Background	involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ggta1^tm1Jbl mutation (2 available); any Ggta1 mutation (83 available)
Igh^tm1Jiac mutation (0 available); any Igh mutation (41 available)
Igk^tm1Jiac mutation (0 available); any Igk mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased mature B cell number ( J:133032 )

• the frequency of B220⁺ B cells in the periphery is 18.7% compared to 24.7% in mice with just one Igh knock-in allele

hematopoietic system

decreased mature B cell number ( J:133032 )

• the frequency of B220⁺ B cells in the periphery is 18.7% compared to 24.7% in mice with just one Igh knock-in allele

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