All Phenotypes Tg(Nr5a1-cre)2Klp MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pdgfra^tm8Sor/Pdgfra^tm8Sor Pdgfrb^tm11Sor/Pdgfrb^tm11Sor Tg(Nr5a1-cre)2Klp/0	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	MGI:3823039
cn2	Pdgfra^tm8Sor/Pdgfra^tm8Sor Tg(Nr5a1-cre)2Klp/0	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	MGI:3823036
cn3	Pdgfrb^tm11Sor/Pdgfrb^tm11Sor Tg(Nr5a1-cre)2Klp/0	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	MGI:3823038
cn4	Tg(Nr5a1-cre)2Klp/0 Trim28^tm1.1Ics/Trim28^tm1.1Ipc	involves: 129S * 129S2/SvPas * C57BL/6J * DBA/2J	MGI:7471248
cn5	Tg(Nr5a1-cre)2Klp/0 Trim28^tm1.1Ipc/Trim28^tm1.1Ipc	involves: 129S * 129S2/SvPas * C57BL/6J * DBA/2J	MGI:7471250
cn6	Shh^tm2Amc/Shh^tm2.1Amc Tg(Nr5a1-cre)2Klp/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	MGI:4889096

Allelic Composition	Pdgfra^tm8Sor/Pdgfra^tm8Sor Pdgfrb^tm11Sor/Pdgfrb^tm11Sor Tg(Nr5a1-cre)2Klp/0
Genetic Background	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfra^tm8Sor mutation (1 available); any Pdgfra mutation (85 available)
Pdgfrb^tm11Sor mutation (1 available); any Pdgfrb mutation (84 available)
Tg(Nr5a1-cre)2Klp mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:142042 )

• few mutants are recovered after birth, however mutants are recovered at E18.5, indicating perinatal lethality

endocrine/exocrine glands

testicular hemorrhage ( J:142042 )

• testes are frequently hemorrhagic at E18.5

abnormal adrenal gland morphology ( J:142042 )

• reduction in steroid-producing cells in the adrenal glands at E18.5

abnormal adrenal cortex morphology ( J:142042 )

• reduction in adrenal cortex

small adrenal glands ( J:142042 )

• small adrenal glands are seen just before birth (E18.5)

abnormal testis morphology ( J:142042 )

• reduction in steroid-producing cells in the testis at E18.5

small testis ( J:142042 )

• small testes at E18.5

cardiovascular system

testicular hemorrhage ( J:142042 )

• testes are frequently hemorrhagic at E18.5

reproductive system

testicular hemorrhage ( J:142042 )

• testes are frequently hemorrhagic at E18.5

abnormal testis morphology ( J:142042 )

• reduction in steroid-producing cells in the testis at E18.5

small testis ( J:142042 )

• small testes at E18.5

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:142042 )

N	• phenotypes observed in testes and ovaries at 6 weeks of age are recoverable by 3 and 6 months of age

oligozoospermia ( J:142042 )

• few sperm are seen within the epididymis at 6 weeks of age

abnormal spermatocyte morphology ( J:142042 )

• observe areas of spermatocyte loss from the testis cords at 6 weeks of age

abnormal ovarian follicle morphology ( J:142042 )

• 6-8 week old females have decreased follicle development

decreased theca cell number ( J:142042 )

• 6-8 week old females have reduced numbers of theca cells in the maturing follicles of the ovaries, although a thin, broken theca interna is seen in the ovary

small ovary ( J:142042 )

• 6-8 week old females have small ovaries

abnormal testis morphology ( J:142042 )

• fewer steroid-producing cells are seen at E12.5-E14.5 in the testis

abnormal testis cord formation ( J:142042 )

• testis cord formation is delayed at E12.5-E14.5

• observe areas of spermatocyte loss from the testis cords at 6 weeks of age

decreased Leydig cell number ( J:142042 )

• reduction in number of adult Leydig cells at 6 weeks of age

small testis ( J:142042 )

• testes are smaller at 6 weeks of age but by 10 weeks they appear normal sized

uterus hypoplasia ( J:142042 )

• 6-8 week old females have underdeveloped uteri

delayed fertility ( J:142042 )

• delay in fertility, however by 3 to 6 months of age, mutants become fertile

anovulation ( J:142042 )

• 6-8 week old females show no evidence of ovlulation

homeostasis/metabolism

decreased circulating estradiol level ( J:142042 )

• 6-8 week old females exhibit lower estradiol levels

abnormal testosterone level ( J:142042 )

• 75% of mutants exhibit low testosterone levels in the testes at 6 weeks of age, however by 10 weeks, levels are higher

endocrine/exocrine glands

abnormal ovarian follicle morphology ( J:142042 )

• 6-8 week old females have decreased follicle development

decreased theca cell number ( J:142042 )

• 6-8 week old females have reduced numbers of theca cells in the maturing follicles of the ovaries, although a thin, broken theca interna is seen in the ovary

small ovary ( J:142042 )

• 6-8 week old females have small ovaries

abnormal testis morphology ( J:142042 )

• fewer steroid-producing cells are seen at E12.5-E14.5 in the testis

abnormal testis cord formation ( J:142042 )

• testis cord formation is delayed at E12.5-E14.5

• observe areas of spermatocyte loss from the testis cords at 6 weeks of age

decreased Leydig cell number ( J:142042 )

• reduction in number of adult Leydig cells at 6 weeks of age

small testis ( J:142042 )

• testes are smaller at 6 weeks of age but by 10 weeks they appear normal sized

cellular

oligozoospermia ( J:142042 )

• few sperm are seen within the epididymis at 6 weeks of age

abnormal spermatocyte morphology ( J:142042 )

• observe areas of spermatocyte loss from the testis cords at 6 weeks of age

Allelic Composition	Pdgfrb^tm11Sor/Pdgfrb^tm11Sor Tg(Nr5a1-cre)2Klp/0
Genetic Background	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfrb^tm11Sor mutation (1 available); any Pdgfrb mutation (84 available)
Tg(Nr5a1-cre)2Klp mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:142042 )

N	• mutants are viable and fertile

Allelic Composition	Tg(Nr5a1-cre)2Klp/0 Trim28^tm1.1Ics/Trim28^tm1.1Ipc
Genetic Background	involves: 129S * 129S2/SvPas * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nr5a1-cre)2Klp mutation (1 available)
Trim28^tm1.1Ics mutation (0 available); any Trim28 mutation (33 available)
Trim28^tm1.1Ipc mutation (1 available); any Trim28 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal ovarian follicle morphology ( J:327192 )

• follicles organized into pseudo-tubular structures (masculinization: transdifferentiation of granulosa cells into Sertoli cells) at age 8 weeks

reproductive system

abnormal ovarian follicle morphology ( J:327192 )

• follicles organized into pseudo-tubular structures (masculinization: transdifferentiation of granulosa cells into Sertoli cells) at age 8 weeks

Allelic Composition	Tg(Nr5a1-cre)2Klp/0 Trim28^tm1.1Ipc/Trim28^tm1.1Ipc
Genetic Background	involves: 129S * 129S2/SvPas * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nr5a1-cre)2Klp mutation (1 available)
Trim28^tm1.1Ipc mutation (1 available); any Trim28 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal ovarian follicle morphology ( J:327192 )

• medullar follicles organized into pseudo-tubular structures (masculinization: transdifferentiation of granulosa cells into Sertoli cells) at age 8 weeks

• remodeling (masculinization) of cortical follicles started by age 8 weeks, though follicles still organized

• all follicles masculinized at age 4 months

endocrine/exocrine glands

abnormal ovarian follicle morphology ( J:327192 )

• medullar follicles organized into pseudo-tubular structures (masculinization: transdifferentiation of granulosa cells into Sertoli cells) at age 8 weeks

• remodeling (masculinization) of cortical follicles started by age 8 weeks, though follicles still organized

• all follicles masculinized at age 4 months

cellular

cellular phenotype ( J:327192 )

N	• normal apoptosis in ovaries at ages P20 and 8 weeks

Allelic Composition	Shh^tm2Amc/Shh^tm2.1Amc Tg(Nr5a1-cre)2Klp/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shh^tm2.1Amc mutation (0 available); any Shh mutation (45 available)
Shh^tm2Amc mutation (1 available); any Shh mutation (45 available)
Tg(Nr5a1-cre)2Klp mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal adrenal gland morphology ( J:168522 )

• adrenal glands exhibit a decrease in stem/precursor cells compared with wild-type mice

abnormal adrenocortical cell morphology ( J:168522 )

• the number of adrenocortical cells is decreased while their size is increased compared to in wild-type mice

enlarged adrenocortical cells ( J:168522 )

thin adrenal cortex ( J:168522 )

small adrenal glands ( J:168522 )

• at P5

abnormal adrenal gland physiology ( J:168522 )

• at E16.5 and P5, adrenal gland cells exhibit reduced proliferation compared with wild-type cells

homeostasis/metabolism

decreased circulating corticosterone level ( J:168522 )

• at P21

increased circulating adrenocorticotropin level ( J:168522 )

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