About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Chattm1(cre)Lowl
targeted mutation 1, Bradford B Lowell
MGI:3689420
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Chattm1(cre)Lowl/Chat+ involves: 129S6/SvEvTac * C57BL/6 MGI:3689725
cn2
 		Brsk2tm2.1Jrs/Brsk2tm2.1Jrs
Chattm1(cre)Lowl/Chat+ 		involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ MGI:5524149
cn3
 		Mc4rtm1Lowl/Mc4rtm1Lowl
Chattm1(cre)Lowl/Chat+ 		involves: 129S4/SvJae * 129S6/SvEvTac MGI:5484740
cn4
 		Mc4rtm2Lowl/Mc4rtm2Lowl
Chattm1(cre)Lowl/Chat+
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+ 		involves: 129S6/SvEvTac * C57BL/6NCr MGI:5484737


Genotype
MGI:3689725
ht1
Allelic
Composition		 Chattm1(cre)Lowl/Chat+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chattm1(cre)Lowl mutation (1 available); any Chat mutation (63 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:114556 )
• heterozygotes are viable and fertile; cre recombinase activity is detected in all cholinergic neurons




Genotype
MGI:5524149
cn2
Allelic
Composition		 Brsk2tm2.1Jrs/Brsk2tm2.1Jrs
Chattm1(cre)Lowl/Chat+
Genetic
Background		 involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brsk2tm2.1Jrs mutation (1 available); any Brsk2 mutation (37 available)
Chattm1(cre)Lowl mutation (1 available); any Chat mutation (63 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:201695 )
N
• type Ia proprioceptive sensory neuron projections grow normally to the ventral horn




Genotype
MGI:5484740
cn3
Allelic
Composition		 Mc4rtm1Lowl/Mc4rtm1Lowl
Chattm1(cre)Lowl/Chat+
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chattm1(cre)Lowl mutation (1 available); any Chat mutation (63 available)
Mc4rtm1Lowl mutation (2 available); any Mc4r mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
hypertension ( J:193452 )
• develop obesity induced hypertension but only during active period

homeostasis/metabolism
increased circulating insulin level ( J:193452 )
• higher plasma insulin levels




Genotype
MGI:5484737
cn4
Allelic
Composition		 Mc4rtm2Lowl/Mc4rtm2Lowl
Chattm1(cre)Lowl/Chat+
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NCr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chattm1(cre)Lowl mutation (1 available); any Chat mutation (63 available)
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze mutation (8 available); any Gt(ROSA)26Sor mutation (1046 available)
Mc4rtm2Lowl mutation (0 available); any Mc4r mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:193452 )
N
• biophysical properties of cholinergic neurons are normal
abnormal nervous system electrophysiology ( J:193452 )
• melanotan II fails to hyperpolarize membrane potentials of all dorsal motor nucleus vagal cholinergic neurons
• similar results with Mc4r agonist THIQ




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory