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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm1Fia
targeted mutation 1, Fraz A Ismat
MGI:3689410
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1Fia/Gt(ROSA)26Sor+
Nf1tm1Par/Nf1tm1Par
Tg(Fabp7-cre,-lacZ)3Gtm/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:3810651
cn2
 		Gt(ROSA)26Sortm1Fia/Gt(ROSA)26Sor+
Nf1tm1Fcr/Nf1tm1Par
Tg(Tek-cre)1Ywa/0 		involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:3689708
cn3
 		Gt(ROSA)26Sortm1Fia/Gt(ROSA)26Sor+
Hprt1tm1(CMV-cre)Brd/Hprt1+
Nf1tm1Fcr/Nf1tm1Fcr 		involves: 129S/SvEv * 129S/SvEvBrd MGI:3689632
cn4
 		Gt(ROSA)26Sortm1Fia/Gt(ROSA)26Sortm1Fia
Hprt1tm1(CMV-cre)Brd/Hprt1+
Nf1tm1Fcr/Nf1tm1Fcr 		involves: 129S/SvEv * 129S/SvEvBrd MGI:3689697


Genotype
MGI:3810651
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1Fia/Gt(ROSA)26Sor+
Nf1tm1Par/Nf1tm1Par
Tg(Fabp7-cre,-lacZ)3Gtm/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Fia mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Nf1tm1Par mutation (4 available); any Nf1 mutation (157 available)
Tg(Fabp7-cre,-lacZ)3Gtm mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
small adenohypophysis ( J:138868 )
• significantly smaller than control littermates

growth/size/body
decreased body weight ( J:138868 )

endocrine/exocrine glands
small adenohypophysis ( J:138868 )
• significantly smaller than control littermates

homeostasis/metabolism
decreased circulating growth hormone level ( J:138868 )
• reduction in liver Igf1 mRNA levels indicates a reduction in circulating growth hormone levels




Genotype
MGI:3689708
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1Fia/Gt(ROSA)26Sor+
Nf1tm1Fcr/Nf1tm1Par
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Fia mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Nf1tm1Fcr mutation (3 available); any Nf1 mutation (157 available)
Nf1tm1Par mutation (4 available); any Nf1 mutation (157 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:114455 )
• 2 embryos are found at later stages, after expected midgestation lethality from cardiovascular failure

hematopoietic system
abnormal spleen morphology ( J:114455 )
• mice display moderate splenic enlargement and partial rescue of splenic architecture
• germinal centers are present
• splenic fibrosis is not observed

immune system
abnormal spleen morphology ( J:114455 )
• mice display moderate splenic enlargement and partial rescue of splenic architecture
• germinal centers are present
• splenic fibrosis is not observed

nervous system
abnormal dorsal root ganglion morphology ( J:114455 )
• marked enlargement of dorsal root ganglia and other neural crest derived tissues is observed




Genotype
MGI:3689632
cn3
Allelic
Composition		 Gt(ROSA)26Sortm1Fia/Gt(ROSA)26Sor+
Hprt1tm1(CMV-cre)Brd/Hprt1+
Nf1tm1Fcr/Nf1tm1Fcr
Genetic
Background		 involves: 129S/SvEv * 129S/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Fia mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Hprt1tm1(CMV-cre)Brd mutation (0 available); any Hprt1 mutation (1274 available)
Nf1tm1Fcr mutation (3 available); any Nf1 mutation (157 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:114455 )
• some mice (5/208) survive to birth while all Nf1-null homozygotes expressing either Gt(ROSA)26Sortm1Fia or Hprt1tm1(CMV-cre)Brd die prior to birth

nervous system
abnormal somatic sensory system morphology ( J:114455 )
• peripheral ganglia are massively enlarged in newborns
abnormal dorsal root ganglion morphology ( J:114455 )
• enormous paraspinal masses arise from the dorsal root ganglia

endocrine/exocrine glands
adrenal medulla hyperplasia ( J:114455 )
• medulla is overgrown compared with wild-type, with cortical effacement and tumor-like medullary protrusion

homeostasis/metabolism
abnormal enzyme/coenzyme level ( J:114455 )
• elevate Ras levels return to wild-type levels by E12.5 with expression of Gt(ROSA)26Sortm1Fia




Genotype
MGI:3689697
cn4
Allelic
Composition		 Gt(ROSA)26Sortm1Fia/Gt(ROSA)26Sortm1Fia
Hprt1tm1(CMV-cre)Brd/Hprt1+
Nf1tm1Fcr/Nf1tm1Fcr
Genetic
Background		 involves: 129S/SvEv * 129S/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Fia mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Hprt1tm1(CMV-cre)Brd mutation (0 available); any Hprt1 mutation (1274 available)
Nf1tm1Fcr mutation (3 available); any Nf1 mutation (157 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal somatic sensory system morphology ( J:114455 )
• peripheral ganglia are massively enlarged in newborns




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory