All Phenotypes Arid4a<tm1Alb> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arid4a^tm1Alb/Arid4a^tm1Alb	involves: 129S7/SvEvBrd	MGI:3817454
hm2	Arid4a^tm1Alb/Arid4a^tm1Alb	involves: 129S7/SvEvBrd * C57BL/6	MGI:3717484
cx3	Arid4a^tm1Alb/Arid4a^tm1Alb Arid4b^tm1Alb/Arid4b⁺	involves: 129S7/SvEvBrd	MGI:3817455
cx4	Arid4a^tm1Alb/Arid4a^tm1Alb Rr70^tm1Alb/Rr70⁺	involves: 129S7/SvEvBrd * C57BL/6	MGI:3717482
cx5	Arid4a^tm1Alb/Arid4a^tm1Alb Arid4b^tm1Alb/Arid4b^tm1Alb	involves: 129S7/SvEvBrd * C57BL/6	MGI:3717487
cx6	Arid4a^tm1Alb/Arid4a^tm1Alb Arid4b^tm1Alb/Arid4b⁺	involves: 129S7/SvEvBrd * C57BL/6	MGI:3717488

Allelic Composition	Arid4a^tm1Alb/Arid4a^tm1Alb
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arid4a^tm1Alb mutation (0 available); any Arid4a mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:141004 )

• mice exhibit increased mortality after 6 months and no mice survives beyond 22 months

reproductive system

ovary hemorrhage ( J:141004 )

• mice exhibit hemorrhage into the ovarian follicles

decreased litter size ( J:141004 )

• female mice mated to wild-type mice exhibit reduced litter size compared to wild-type female mice

hematopoietic system

enlarged spleen ( J:141004 )

• after 5 months

abnormal definitive hematopoiesis ( J:141004 )

abnormal mononuclear cell differentiation ( J:141004 )

• beyond 5 months of age, mice exhibit immature and maturing mononuclear cells in the peripheral blood unlike wild-type mice

abnormal common myeloid progenitor cell morphology ( J:141004 )

• increased in the spleen and bone marrow

extramedullary hematopoiesis ( J:141004 )

• after 5 months, mice exhibit extramedullary hematopoiesis in the liver and spleen

• after 5 months, mice exhibit increased erythropoiesis in the spleen

anemia ( J:141004 )

• at 2 to 5 months of age, mice exhibit mild anemia that becomes severe beyond 5 months of age

increased erythroid progenitor cell number ( J:141004 )

• in mice older than 5 months

decreased erythrocyte cell number ( J:141004 )

• the bone marrow of mice with symptoms of chronic myelomonocytic leukemia (CMML)

increased erythrocyte cell number ( J:141004 )

• in the spleens of mice with symptoms of chronic myelomonocytic leukemia (CMML)

poikilocytosis ( J:141004 )

• in mice older than 5 months

thrombocytopenia ( J:141004 )

• at 2 to 5 months of age, mice exhibit a progressive loss of platelets that becomes severe beyond 5 months of age

decreased leukocyte cell number ( J:141004 )

• at 2 to 5 months of age, mice exhibit mild leukopenia

decreased neutrophil cell number ( J:141004 )

• at 2 to 5 months of age

decreased lymphocyte cell number ( J:141004 )

• at 2 to 5 months of age

decreased B cell number ( J:141004 )

• the bone marrow of mice with symptoms of chronic myelomonocytic leukemia (CMML)

decreased T cell number ( J:141004 )

• in the spleen of mice with symptoms of chronic myelomonocytic leukemia (CMML)

decreased monocyte cell number ( J:141004 )

• beyond 5 months of age

increased leukocyte cell number ( J:141004 )

• spleens mice with symptoms of chronic myelomonocytic leukemia (CMML)

• 12% of mice develop acute myeloid leukemia with a rapid increase in white blood cell count between 12 and 22 months

increased T cell number ( J:141004 )

• the bone marrow of mice with symptoms of chronic myelomonocytic leukemia (CMML)

increased hematopoietic stem cell number ( J:141004 )

• in the bone marrow and spleen

endocrine/exocrine glands

ovary hemorrhage ( J:141004 )

• mice exhibit hemorrhage into the ovarian follicles

liver/biliary system

enlarged liver ( J:141004 )

• after 5 months

neoplasm

increased leukemia incidence ( J:141004 )

• mice exhibit chronic myelomonocytic leukemia (CMML) symptoms

• 12% of mice develop acute myeloid leukemia with a rapid increase in white blood cell count between 12 and 22 months

increased sarcoma incidence ( J:141004 )

• mice with acute myeloid leukemia (AML) also develop myeloid sarcomas in spleens and livers

skeleton

abnormal bone marrow morphology ( J:141004 )

• sick mice exhibit bone marrow with reticulin fibrosis and increased apoptosis compared to wild type mice

• hematopoietic stem cell populations are expanded in the bone marrow compared to in wild-type mice

• the bone marrow of mice with symptoms of chronic myelomonocytic leukemia (CMML) exhibits an increase in T cells and a decreased in erythrocytes and B cells compared to in wild-type mice

myelofibrosis ( J:141004 )

• sick mice exhibit bone marrow with reticulin fibrosis

respiratory system

increased pulmonary respiratory rate ( J:141004 )

• in mice older than 5 months

cardiovascular system

ovary hemorrhage ( J:141004 )

• mice exhibit hemorrhage into the ovarian follicles

behavior/neurological

decreased locomotor activity ( J:141004 )

• in mice older than 5 months

immune system

abnormal mononuclear cell differentiation ( J:141004 )

• beyond 5 months of age, mice exhibit immature and maturing mononuclear cells in the peripheral blood unlike wild-type mice

enlarged spleen ( J:141004 )

• after 5 months

decreased leukocyte cell number ( J:141004 )

• at 2 to 5 months of age, mice exhibit mild leukopenia

decreased neutrophil cell number ( J:141004 )

• at 2 to 5 months of age

decreased lymphocyte cell number ( J:141004 )

• at 2 to 5 months of age

decreased B cell number ( J:141004 )

• the bone marrow of mice with symptoms of chronic myelomonocytic leukemia (CMML)

decreased T cell number ( J:141004 )

• in the spleen of mice with symptoms of chronic myelomonocytic leukemia (CMML)

decreased monocyte cell number ( J:141004 )

• beyond 5 months of age

increased leukocyte cell number ( J:141004 )

• spleens mice with symptoms of chronic myelomonocytic leukemia (CMML)

• 12% of mice develop acute myeloid leukemia with a rapid increase in white blood cell count between 12 and 22 months

increased T cell number ( J:141004 )

• the bone marrow of mice with symptoms of chronic myelomonocytic leukemia (CMML)

integument

ruffled hair ( J:141004 )

• in mice older than 5 months

cellular

abnormal mononuclear cell differentiation ( J:141004 )

• beyond 5 months of age, mice exhibit immature and maturing mononuclear cells in the peripheral blood unlike wild-type mice

growth/size/body

enlarged liver ( J:141004 )

• after 5 months

enlarged spleen ( J:141004 )

• after 5 months

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
acute myeloid leukemia		DOID:9119	OMIM:601626	J:141004

Allelic Composition	Arid4a^tm1Alb/Arid4a^tm1Alb
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arid4a^tm1Alb mutation (0 available); any Arid4a mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

genetic imprinting ( J:113402 )

• DNA methylation is normal

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:141004 )

• mice exhibit increased mortality at 7 months of age

postnatal lethality ( J:141004 )

• 25% of mice die before 1 month

hematopoietic system

enlarged spleen ( J:141004 )

• in mice with acute myeloid leukemia (AML)

abnormal definitive hematopoiesis ( J:141004 )

abnormal common myeloid progenitor cell morphology ( J:141004 )

• increased in the spleen and bone marrow

abnormal leukopoiesis ( J:141004 )

• mice that exhibit acute myeloid leukemia also present with bone marrow containing a mixture of immature and dysplastic white blood cell precursors with more than 20% non-lymphoid immature forms and blasts unlike in wild-type mice

extramedullary hematopoiesis ( J:141004 )

abnormal myeloblast morphology/development ( J:141004 )

• the peripheral blood of mice with acute myeloid leukemia (AML) contains more than 20% atypical cells with morphology consistent with blasts and immature myeloid precursors unlike in wild-type mice

decreased erythrocyte cell number ( J:141004 )

• the bone marrow of mice with acute myeloid leukemia (AML)

increased erythrocyte cell number ( J:141004 )

• the spleen of mice of mice with acute myeloid leukemia (AML)

thrombocytopenia ( J:141004 )

• in the peripheral blood of mice with acute myeloid leukemia (AML)

decreased lymphocyte cell number ( J:141004 )

• in the peripheral blood of mice with acute myeloid leukemia (AML)

decreased B cell number ( J:141004 )

• the bone marrow and spleens of mice with acute myeloid leukemia (AML)

decreased T cell number ( J:141004 )

• the spleen of mice with acute myeloid leukemia (AML)

increased leukocyte cell number ( J:141004 )

• the bone marrow spleens of mice with acute myeloid leukemia (AML)

increased neutrophil cell number ( J:141004 )

• in mice with acute myeloid leukemia (AML)

increased T cell number ( J:141004 )

• the bone marrow of mice with acute myeloid leukemia (AML)

increased monocyte cell number ( J:141004 )

• mice with acute myeloid leukemia (AML) exhibit monocytosis

increased hematopoietic stem cell number ( J:141004 )

• hematopoietic stem cell populations are expanded in the bone marrow and spleen compared to in wild-type mice and Arid4a^tm1Alb homozygotes

hemophagocytosis ( J:141004 )

• mice with acute myeloid leukemia (AML) exhibit hemophagocytosis

neoplasm

increased leukemia incidence ( J:141004 )

• 83% of mice develop acute myeloid leukemia between 7 and 15 months of age

increased sarcoma incidence ( J:141004 )

• mice with acute myeloid leukemia (AML) also develop myeloid sarcomas in spleens and livers

liver/biliary system

enlarged liver ( J:141004 )

• in mice with acute myeloid leukemia (AML)

skeleton

abnormal bone marrow morphology ( J:141004 )

• mice that exhibit acute myeloid leukemia (AML) also present with bone marrow containing a mixture of immature and dysplastic white blood cell precursors with more than 20% non-lymphoid immature forms and blasts unlike in wild-type mice

• the bone marrow of mice with AML increase in granulocytes, monocytes, T lymphoid cells, and erythroid cells and a decrease in B lymphoid cells compared to in wild-type mice

• hematopoietic stem cell populations are expanded in the bone marrow compared to in wild-type mice and Arid4a^tm1Alb homozygotes

respiratory system

abnormal lung vasculature morphology ( J:141004 )

• mice with acute myeloid leukemia (AML) exhibit nucleated elements in lung blood vessels indicative of leukemic involvement

cardiovascular system

abnormal blood vessel morphology ( J:141004 )

• mice with acute myeloid leukemia (AML) exhibit nucleated elements in lung, kidney and lymph node blood vessels indicative of leukemic involvement

abnormal kidney vasculature morphology ( J:141004 )

• mice with acute myeloid leukemia (AML) exhibit nucleated elements in kidney blood vessels indicative of leukemic involvement

abnormal lung vasculature morphology ( J:141004 )

• mice with acute myeloid leukemia (AML) exhibit nucleated elements in lung blood vessels indicative of leukemic involvement

renal/urinary system

abnormal kidney vasculature morphology ( J:141004 )

• mice with acute myeloid leukemia (AML) exhibit nucleated elements in kidney blood vessels indicative of leukemic involvement

growth/size/body

decreased body weight ( J:141004 )

• at 7 weeks of age, mice weigh 30% less than wild-type mice

enlarged liver ( J:141004 )

• in mice with acute myeloid leukemia (AML)

enlarged spleen ( J:141004 )

• in mice with acute myeloid leukemia (AML)

immune system

enlarged spleen ( J:141004 )

• in mice with acute myeloid leukemia (AML)

abnormal leukopoiesis ( J:141004 )

decreased lymphocyte cell number ( J:141004 )

• in the peripheral blood of mice with acute myeloid leukemia (AML)

decreased B cell number ( J:141004 )

• the bone marrow and spleens of mice with acute myeloid leukemia (AML)

decreased T cell number ( J:141004 )

• the spleen of mice with acute myeloid leukemia (AML)

increased leukocyte cell number ( J:141004 )

• the bone marrow spleens of mice with acute myeloid leukemia (AML)

increased neutrophil cell number ( J:141004 )

• in mice with acute myeloid leukemia (AML)

increased T cell number ( J:141004 )

• the bone marrow of mice with acute myeloid leukemia (AML)

increased monocyte cell number ( J:141004 )

• mice with acute myeloid leukemia (AML) exhibit monocytosis

hemophagocytosis ( J:141004 )

• mice with acute myeloid leukemia (AML) exhibit hemophagocytosis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
acute myeloid leukemia		DOID:9119	OMIM:601626	J:141004

Allelic Composition	Arid4a^tm1Alb/Arid4a^tm1Alb Rr70^tm1Alb/Rr70⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arid4a^tm1Alb mutation (0 available); any Arid4a mutation (60 available)
Rr70^tm1Alb mutation (0 available); any Rr70 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal DNA methylation ( J:113402 )

abnormal imprinting ( J:113402 )

• 7 of 12 mice lack correct DNA methylation patterns

Allelic Composition	Arid4a^tm1Alb/Arid4a^tm1Alb Arid4b^tm1Alb/Arid4b^tm1Alb
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arid4a^tm1Alb mutation (0 available); any Arid4a mutation (60 available)
Arid4b^tm1Alb mutation (0 available); any Arid4b mutation (65 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:113402 )

• mice are not viable

Allelic Composition	Arid4a^tm1Alb/Arid4a^tm1Alb Arid4b^tm1Alb/Arid4b⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal DNA methylation during gametogenesis ( J:113402 )

abnormal imprinting ( J:113402 )

• 1 of 7 mice lacks correct DNA methylation patterns

• trimethylation at H4K20 is lost in all mice

maternal imprinting ( J:113402 )

• maternal imprinting is defective

reproductive system

abnormal DNA methylation during gametogenesis ( J:113402 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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