Phenotypes associated with this allele

• Allele Symbol: Mecom⁺
• Allele Name: wild type
• Allele ID: MGI:3686769
• Summary: 7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Mecom^tm1.1Miku/Mecom^+	B6.Cg-Mecom^tm1.1Miku	MGI:3849425
ht2	Mecom^Jbo/Mecom^+	C3N.C-Mecom^Jbo	MGI:3689583
ht3	Mecom^em1(IMPC)J/Mecom^+	C57BL/6NJ-Mecom^em1(IMPC)J/Mmjax	MGI:6696817
ht4	Mecom^Jbo/Mecom^+	involves: BALB/c	MGI:6102908
ht5	Mecom^tm2Miku/Mecom^+	involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj	MGI:5306623
ht6	Mecom^tm1.1Miku/Mecom^+	involves: C57BL/6NCrlj * CBA/JNCrlj	MGI:5306624
cn7	Mecom^tm1Miku/Mecom^+ Tg(Tek-cre)12Flv/0	involves: C3H * C57BL/6 * CBA	MGI:3849427

Genotype
MGI:3849425

ht1

• Allelic Composition: Mecom^tm1.1Miku/Mecom⁺
• Genetic Background: B6.Cg-Mecom^tm1.1Miku

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal platelet morphology ( J:149794 )

• platelets have delayed recovery of numbers after administration of Fluorouracil

abnormal hematopoietic stem cell morphology ( J:149794 )

• less mutant HSC than wild-type HSC reconstitute the bone marrow of lethally irradiated mice in competitive reconstitution assays

decreased hematopoietic stem cell number ( J:149794 )

• the population of lin^- Kit⁺CD34⁺ found among E14.5 fetal liver cells 2-3 fold compared to controls

• this population is also reduced by about half in the bone marrow of adult mice

Genotype
MGI:3689583

ht2

• Allelic Composition: Mecom^Jbo/Mecom⁺
• Genetic Background: C3N.C-Mecom^Jbo

Polydactyly in Mecom^Jbo/Evi1⁺ and Mecom^Jbo/Mecom^Jbo mice

hearing/vestibular/ear

abnormal tympanic membrane morphology ( J:113445 )

• fibrous thickening and perforation of the tympanic membrane associated with otitis media were common among adult heterozygotes over 29 days after birth

tympanic membrane perforation ( J:113445 )

• common among adult heterozygotes over 29 days after birth

deafness ( J:90559 , J:113445 )

• late onset (J:90559)

• demonstrated a hearing loss at approximately 40 days after birth (J:113445)

increased susceptibility to otitis media ( J:113445 )

• the middle ear cavity of adult mutant mice was filled with exudate, indicative of otitis media

• otitis media was resent in 100% of heterozygotes at weaning and continue to develop bilateral chronic suppurative otitis media

• no gross morphological defects of the inner ear and ossicular chain or ossification of the temporal bone and tympanic ring were found among mutant mice

• in conventionally housed mice, 100% of the mutant mice had acute otitis media by 13 days after birth compared to about 33% in wild-type

• in pathogen free facility condition, otitis media in mutant mice are relatively milder or absent at early time points and is not associated with rhinitis; however otitis media developed in 100% of mutant mice in this condition by 54 days after birth

reproductive system

increased miscarriage rate ( J:113445 )

♀ • female heterozygotes undergo repeated spontaneous abortion

limbs/digits/tail

polydactyly ( J:90559 , J:113445 )

• extra digit (J:90559)

• an extra digit is seen on one forelimb at E18.5 (J:113445)

immune system

immune system phenotype ( J:113445 )

N • no significant histological lesions in intestine, liver, pancreas, kidney, heart, thymus, and spleen

N • no significances in the antibody responses, levels of immature, mature cell forms, and total circulating blood neutrophils

abnormal neutrophil differentiation ( J:113445 )

• significantly lower ratio of immature forms in the circulating neutrophil pool in 20-22 days after birth mutant, but not in 54-58 days after birth, compared to control

increased susceptibility to otitis media ( J:113445 )

• the middle ear cavity of adult mutant mice was filled with exudate, indicative of otitis media

• otitis media was resent in 100% of heterozygotes at weaning and continue to develop bilateral chronic suppurative otitis media

• no gross morphological defects of the inner ear and ossicular chain or ossification of the temporal bone and tympanic ring were found among mutant mice

• in conventionally housed mice, 100% of the mutant mice had acute otitis media by 13 days after birth compared to about 33% in wild-type

• in pathogen free facility condition, otitis media in mutant mice are relatively milder or absent at early time points and is not associated with rhinitis; however otitis media developed in 100% of mutant mice in this condition by 54 days after birth

respiratory system inflammation ( J:113445 )

• in conventionally housed mice, otitis media found in 100% of heterozygotes mice are part of a more generalized respiratory tract inflammation

• no significant intralesional bacteria or viral inclusions

respiratory system

respiratory system inflammation ( J:113445 )

• in conventionally housed mice, otitis media found in 100% of heterozygotes mice are part of a more generalized respiratory tract inflammation

• no significant intralesional bacteria or viral inclusions

hematopoietic system

abnormal neutrophil differentiation ( J:113445 )

• significantly lower ratio of immature forms in the circulating neutrophil pool in 20-22 days after birth mutant, but not in 54-58 days after birth, compared to control

cellular

abnormal neutrophil differentiation ( J:113445 )

• significantly lower ratio of immature forms in the circulating neutrophil pool in 20-22 days after birth mutant, but not in 54-58 days after birth, compared to control

craniofacial

abnormal craniofacial morphology ( J:90559 )

• craniofacial defect

growth/size/body

decreased body weight ( J:90559 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
otitis media		DOID:10754		J:113445

Genotype
MGI:6696817

ht3

• Allelic Composition: Mecom^em1(IMPC)J/Mecom⁺
• Genetic Background: C57BL/6NJ-Mecom^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Mecom

hematopoietic system

thrombocytopenia ( J:211773 )

IMPC - JAX

Genotype
MGI:6102908

ht4

• Allelic Composition: Mecom^Jbo/Mecom⁺
• Genetic Background: involves: BALB/c

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:250208 )

N • mice exhibit normal inner ear morphology

middle ear effusion ( J:250208 )

middle ear polyps ( J:250208 )

• edematous polyps projecting into the middle ear cavity

impaired hearing ( J:250208 )

• poor performance to the click-box

increased susceptibility to otitis media ( J:250208 )

• chronic suppurative with a granulocytic effusion and a thickened mucoperisoteum

behavior/neurological

abnormal pinna reflex ( J:250208 )

• poor performance to the click-box

homeostasis/metabolism

middle ear effusion ( J:250208 )

immune system

increased susceptibility to otitis media ( J:250208 )

• chronic suppurative with a granulocytic effusion and a thickened mucoperisoteum

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
otitis media		DOID:10754		J:250208

Genotype
MGI:5306623

ht5

• Allelic Composition: Mecom^tm2Miku/Mecom⁺
• Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

normal phenotype

no abnormal phenotype detected ( J:178616 )

• mice are phenotypically indistinguishable in survival, hematopoietic cellularity, and lineage composition from wild-type controls

Genotype
MGI:5306624

ht6

• Allelic Composition: Mecom^tm1.1Miku/Mecom⁺
• Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

hematopoietic system

decreased hematopoietic stem cell number ( J:178616 )

• mice exhibit an almost complete loss of long-term hematopoietic stem cells in a cell-autonomous manner compared with wild-type mice

abnormal hematopoietic stem cell physiology ( J:178616 )

• short-term and long-term hematopoietic stem cells self-renewal capacity is abrogated, as measured by reduced colony-forming units (granulocyte-macrophage and granulocyte-erythrocyte-monocyte-megakaryocyte progenitors) and erythroid burst-forming units, compared with wild-type cells

Genotype
MGI:3849427

cn7

• Allelic Composition: Mecom^tm1Miku/Mecom⁺; Tg(Tek-cre)12Flv/0
• Genetic Background: involves: C3H * C57BL/6 * CBA

hematopoietic system

decreased hematopoietic stem cell number ( J:149794 )

• the population of lin^- Kit⁺CD34⁺ found among E14.5 fetal liver cells is somewhat reduced