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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Wt1tm2Vih
targeted mutation 2, Vicki Huff
MGI:3665320
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Plekha5Tg(AMH-cre)1Flor/Plekha5+
Wt1tm1Jae/Wt1tm2Vih 		involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL MGI:3690050


Genotype
MGI:3690050
cn1
Allelic
Composition		 Plekha5Tg(AMH-cre)1Flor/Plekha5+
Wt1tm1Jae/Wt1tm2Vih
Genetic
Background		 involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plekha5Tg(AMH-cre)1Flor mutation (1 available); any Plekha5 mutation (109 available)
Wt1tm1Jae mutation (3 available); any Wt1 mutation (34 available)
Wt1tm2Vih mutation (1 available); any Wt1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal male reproductive system morphology ( J:111787 )
• in addition to reduced testes size, remainder of reproductive tract is hypoplastic
• histological analysis of proximal portion of male reproductive tract shows structures with coiled morphology and folded epithelium structure of oviduct
abnormal testis morphology ( J:111787 )
• at E13.5, male testicular development, including Sertoli cell location and numbers appears normal, but from E15.5 to P7, development is abnormal
abnormal seminiferous tubule morphology ( J:111787 )
• testes completely lack normal tubular architecture of controls and consist primarily of sheets of eosinophilic cells
• at E15.5, only a few tubule-like structures are observed
abnormal Leydig cell morphology ( J:111787 )
• testes contain sheets of eosinophilic cells identified histologically as Leydig cells; these cells are observed in dense clusters interspersed with regions of fibroblast-like cells
small testis ( J:111787 )
• in 7 week old males, testes size is ~10% of control wild-type littermates
abnormal secondary sex determination ( J:111787 )
• males have a uterus in addition to vas deferens, epididymis, and seminal vesicles
• histological analysis of proximal portion of male reproductive tract shows structures with coiled morphology and folded epithelium structure of oviduct
male infertility ( J:111787 )
• based on aberrant structure of male testes, males are predicted to be sterile

endocrine/exocrine glands
abnormal testis morphology ( J:111787 )
• at E13.5, male testicular development, including Sertoli cell location and numbers appears normal, but from E15.5 to P7, development is abnormal
abnormal seminiferous tubule morphology ( J:111787 )
• testes completely lack normal tubular architecture of controls and consist primarily of sheets of eosinophilic cells
• at E15.5, only a few tubule-like structures are observed
abnormal Leydig cell morphology ( J:111787 )
• testes contain sheets of eosinophilic cells identified histologically as Leydig cells; these cells are observed in dense clusters interspersed with regions of fibroblast-like cells
small testis ( J:111787 )
• in 7 week old males, testes size is ~10% of control wild-type littermates




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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory