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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Map3k7tm1.1Aki
targeted mutation 1.1, Shizuo Akira
MGI:3664194
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Map3k7tm1.1Aki/Map3k7tm1.1Aki involves: 129P2/OlaHsd * C57BL/6 MGI:3664611
cn2
 		Cd19tm1(cre)Cgn/Cd19+
Map3k7tm1Aki/Map3k7tm1.1Aki 		involves: 129P2/OlaHsd * C57BL/6 MGI:3664610


Genotype
MGI:3664611
hm1
Allelic
Composition		 Map3k7tm1.1Aki/Map3k7tm1.1Aki
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k7tm1.1Aki mutation (0 available); any Map3k7 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cellular
absent fibroblast proliferation ( J:112597 )
• MEFs from E9.5 embryos fail to grow in culture




Genotype
MGI:3664610
cn2
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Map3k7tm1Aki/Map3k7tm1.1Aki
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (56 available)
Map3k7tm1.1Aki mutation (0 available); any Map3k7 mutation (51 available)
Map3k7tm1Aki mutation (0 available); any Map3k7 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B-1 B cell number ( J:112597 )
• decrease in the number of B220+CD5+ B-1 B cells in the peritoneal cavity
abnormal B cell physiology ( J:112597 )
• impaired B cell survival following LPS or CpG DNA stimulation or B cell receptor crosslinking
decreased B cell proliferation ( J:112597 )
• decreased LPS- and/or CpG DNA-induced proliferation in follicular and marginal zone B-2 cells with impaired entry in S phase; however, LPS- and/or CpG DNA-induced IL6 production is similar to wild-type
• decreased proliferation in response to B cell receptor and CD40 stimulation with impaired entry into S phase and impaired survival following B cell receptor crosslinking
decreased immunoglobulin level ( J:112597 )
• decrease for all isotypes except IgM
decreased IgG level ( J:112597 )
• decreased levels of IgG1 and IgG3 following T cell dependent or T cell independent antigen stimulation, respectively; however, levels of IgM are similar to control following T cell dependent antigen stimulation

hematopoietic system
decreased B-1 B cell number ( J:112597 )
• decrease in the number of B220+CD5+ B-1 B cells in the peritoneal cavity
abnormal B cell physiology ( J:112597 )
• impaired B cell survival following LPS or CpG DNA stimulation or B cell receptor crosslinking
decreased B cell proliferation ( J:112597 )
• decreased LPS- and/or CpG DNA-induced proliferation in follicular and marginal zone B-2 cells with impaired entry in S phase; however, LPS- and/or CpG DNA-induced IL6 production is similar to wild-type
• decreased proliferation in response to B cell receptor and CD40 stimulation with impaired entry into S phase and impaired survival following B cell receptor crosslinking
decreased immunoglobulin level ( J:112597 )
• decrease for all isotypes except IgM
decreased IgG level ( J:112597 )
• decreased levels of IgG1 and IgG3 following T cell dependent or T cell independent antigen stimulation, respectively; however, levels of IgM are similar to control following T cell dependent antigen stimulation

cellular
decreased B cell proliferation ( J:112597 )
• decreased LPS- and/or CpG DNA-induced proliferation in follicular and marginal zone B-2 cells with impaired entry in S phase; however, LPS- and/or CpG DNA-induced IL6 production is similar to wild-type
• decreased proliferation in response to B cell receptor and CD40 stimulation with impaired entry into S phase and impaired survival following B cell receptor crosslinking




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory