Map3k7^tm1.1Aki
Targeted Allele Detail

Summary

• Symbol: Map3k7^tm1.1Aki
• Name: mitogen-activated protein kinase kinase kinase 7; targeted mutation 1.1, Shizuo Akira
• MGI ID: MGI:3664194
• Synonyms: Map3k7^-, TAK1^-
• Gene: Map3k7 Location: Chr4:31964097-32023467 bp, + strand Genetic Position: Chr4, 13.91 cM
• Alliance: Map3k7^tm1.1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112597
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 2 was removed via cre-mediated recombination. Exon 2 encodes a part of the kinase domain, including the ATP-binding site. (J:112597)

Expression

In Mice Carrying this Mutation:	19 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map3k7 Mutation: 51 strains or lines available

References

• Original: J:112597 Sato S, et al., Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat Immunol. 2005 Nov;6(11):1087-95
• All: 5 reference(s)