About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tmprss13tm1Dgen
targeted mutation 1, Deltagen
MGI:3663353
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tmprss13tm1Dgen/Tmprss13tm1Dgen involves: 129P2/OlaHsd * C57BL/6 MGI:3663354
hm2
Tmprss13tm1Dgen/Tmprss13tm1Dgen involves: 129P2/OlaHsd * C57BL/6J MGI:5688589


Genotype
MGI:3663354
hm1
Allelic
Composition
Tmprss13tm1Dgen/Tmprss13tm1Dgen
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmprss13tm1Dgen mutation (1 available); any Tmprss13 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:5688589
hm2
Allelic
Composition
Tmprss13tm1Dgen/Tmprss13tm1Dgen
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmprss13tm1Dgen mutation (1 available); any Tmprss13 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
N
• surprisingly, newborn homozygotes display normal tight junction formation and profilaggrin processing in the epidermis
• no abnormalities in pelage hair eruption or pelage hair appearance are observed
• however, no differences in birth weight, postnatal or long term survival are observed
• newborn homozygotes show a 54% increase in the transepidermal fluid loss rate relative to wild-type controls
• at birth, homozygotes show a 30% reduction in whisker length relative to wild-type controls; however, this difference is transient, as normal size whiskers are observed in adulthood
• newborn homozygotes show an abnormally compacted stratum corneum, with fewer and smaller intercorneocyte lacunae than wild-type controls, indicating a defect in stratum corneum maturation
• the thickness of neonatal stratum corneum is reduced by 38%, whereas the thickness of the living (basal, spinous and granular/transitional) layer of the epidermis is normal
• however, no abnormalities are observed in the adult stratum corneum

homeostasis/metabolism
N
• blood chemistry analysis revealed no significant changes in the serum levels of alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, amylase, and creatine kinase, and only a moderate increase in lactate dehydrogenase levels
• newborn homozygotes show a 54% increase in the transepidermal fluid loss rate relative to wild-type controls
• however, no differences in birth weight, postnatal or long term survival are observed





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
07/05/2024
MGI 6.24
The Jackson Laboratory