Phenotypes associated with this allele

• Allele Symbol: Tmprss13^tm1Dgen
• Allele Name: targeted mutation 1, Deltagen
• Allele ID: MGI:3663353
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tmprss13^tm1Dgen/Tmprss13^tm1Dgen	involves: 129P2/OlaHsd * C57BL/6	MGI:3663354
hm2	Tmprss13^tm1Dgen/Tmprss13^tm1Dgen	involves: 129P2/OlaHsd * C57BL/6J	MGI:5688589

Genotype
MGI:3663354

hm1

• Allelic Composition: Tmprss13^tm1Dgen/Tmprss13^tm1Dgen
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:101679 )

Genotype
MGI:5688589

hm2

• Allelic Composition: Tmprss13^tm1Dgen/Tmprss13^tm1Dgen
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

integument

integument phenotype ( J:215250 )

N • surprisingly, newborn homozygotes display normal tight junction formation and profilaggrin processing in the epidermis

N • no abnormalities in pelage hair eruption or pelage hair appearance are observed

impaired skin barrier function ( J:215250 )

• newborn homozygotes show a 54% increase in the transepidermal fluid loss rate relative to wild-type controls

• however, no differences in birth weight, postnatal or long term survival are observed

short vibrissae ( J:215250 )

• at birth, homozygotes show a 30% reduction in whisker length relative to wild-type controls; however, this difference is transient, as normal size whiskers are observed in adulthood

abnormal epidermis stratum corneum morphology ( J:215250 )

• newborn homozygotes show an abnormally compacted stratum corneum, with fewer and smaller intercorneocyte lacunae than wild-type controls, indicating a defect in stratum corneum maturation

• the thickness of neonatal stratum corneum is reduced by 38%, whereas the thickness of the living (basal, spinous and granular/transitional) layer of the epidermis is normal

• however, no abnormalities are observed in the adult stratum corneum

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:215250 )

N • blood chemistry analysis revealed no significant changes in the serum levels of alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, amylase, and creatine kinase, and only a moderate increase in lactate dehydrogenase levels

impaired skin barrier function ( J:215250 )

• newborn homozygotes show a 54% increase in the transepidermal fluid loss rate relative to wild-type controls

• however, no differences in birth weight, postnatal or long term survival are observed