Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ube2ntm1Aki mutation
(0 available);
any
Ube2n mutation
(20 available)
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normal phenotype
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• mice are born in expected ratios and show no obvious abnormalities
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation
(14 available);
any
Lyz2 mutation
(41 available)
Ube2ntm1Aki mutation
(0 available);
any
Ube2n mutation
(20 available)
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immune system
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• upon TLR ligand stimulation, macrophages produce less TNF,Il-6 and Il-12p40 than those in conrols
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hematopoietic system
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• upon TLR ligand stimulation, macrophages produce less TNF,Il-6 and Il-12p40 than those in conrols
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation
(11 available);
any
Cd19 mutation
(56 available)
Ube2ntm1Aki mutation
(0 available);
any
Ube2n mutation
(20 available)
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immune system
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• B cells expressing B220, CD38 and CD21 are present in lower numbers
• fewer B cells enter S phase after stimulation with anti-IgM, anti-CD40, LPS or CpG DNA
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• width of marginal zone B cell area is smaller than in controls
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• mice have a much lower frequency of B220+CD21hiCD23low marginal zone B cells
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• mice show defective MAP kinase activation in B cells
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• more mutant B cells undergo apoptosis ex vivo even after stimulation with LPS, CpG DNA or anti-CD40
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• B cells stimulated with LPS or CpG DNA show a lower proliferative response than controls
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• all isotypes except IgG2a and IgG2b are significantly lower than in controls
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• after immunization with TNP-ficoll or TNP-chicken gammaglobulin mice produce less serum TNP-specific IgM and IgG3
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hematopoietic system
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• B cells expressing B220, CD38 and CD21 are present in lower numbers
• fewer B cells enter S phase after stimulation with anti-IgM, anti-CD40, LPS or CpG DNA
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• width of marginal zone B cell area is smaller than in controls
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• mice have a much lower frequency of B220+CD21hiCD23low marginal zone B cells
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• mice show defective MAP kinase activation in B cells
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• more mutant B cells undergo apoptosis ex vivo even after stimulation with LPS, CpG DNA or anti-CD40
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• B cells stimulated with LPS or CpG DNA show a lower proliferative response than controls
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• all isotypes except IgG2a and IgG2b are significantly lower than in controls
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cellular
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• more mutant B cells undergo apoptosis ex vivo even after stimulation with LPS, CpG DNA or anti-CD40
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• B cells stimulated with LPS or CpG DNA show a lower proliferative response than controls
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