Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xrcc2tm1Pmc mutation
(1 available);
any
Xrcc2 mutation
(17 available)
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mortality/aging
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• lethality around E9-10 is observed
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cellular
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• abundant apoptosis of proliferating cells is observed, particularly in the forebrain and hindbrain structures in embryos isolated at later stages
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Pmc mutation
(0 available);
any
Atm mutation
(169 available)
Xrcc2tm1Pmc mutation
(1 available);
any
Xrcc2 mutation
(17 available)
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mortality/aging
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• embryos are recovered at the same frequency as Xrcc2 single mutants indicating Atm deficiency does not provide a survival advantage
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mortality/aging
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• mice are less robust than Lig4/Trp53 double homozygotes and often die perinatally of indeterminate causes
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growth/size/body
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• mice are smaller and less robust than wild-type littermates
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nervous system
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• apoptosis is markedly reduced in double mutants
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neoplasm
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• surviving double mutants all develop multiple tumor types with a rapid onset and with different tumor types present by 10 weeks of age
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• these are B220 negative and distinct from the pro-B cell lymphomas
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• thymomas contain multiple chromosomal rearrangements but no recurring chromosomal rearrangements are observed in primary tumors
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integument
cellular
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• apoptosis is markedly reduced in double mutants
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endocrine/exocrine glands
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• thymomas contain multiple chromosomal rearrangements but no recurring chromosomal rearrangements are observed in primary tumors
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growth/size/body
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• mice are smaller and less robust than wild-type littermates
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neoplasm
endocrine/exocrine glands
Analysis Tools