All Phenotypes Cast<tm1Tcs> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cast^tm1Tcs
targeted mutation 1, Takaomi C Saido
MGI:3641275

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cast^tm1Tcs/Cast^tm1Tcs	B6.129-Cast^tm1Tcs	MGI:3652404
cx2	Capn2^tm1Tcs/Capn2^tm1Tcs Cast^tm1Tcs/Cast^tm1Tcs	B6.129-Capn2^tm1Tcs Cast^tm1Tcs	MGI:5292741
cx3	Capn1^tm1Ahc/Capn1^tm1Ahc Capn2^tm1Tcs/Capn2^tm1Tcs Cast^tm1Tcs/Cast^tm1Tcs	B6.129-Capn2^tm1Tcs Cast^tm1Tcs Capn1^tm1Ahc	MGI:5292742
cx4	App^tm2.1Tcs/App^tm2.1Tcs Cast^tm1Tcs/Cast^tm1Tcs	involves: 129P2/OlaHsd * C57BL/6	MGI:5638676

Allelic Composition	Cast^tm1Tcs/Cast^tm1Tcs
Genetic Background	B6.129-Cast^tm1Tcs

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cast^tm1Tcs mutation (1 available); any Cast mutation (62 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased susceptibility to neuronal excitotoxicity ( J:109976 )

• Cast deficiency results in augmented DNA fragmentation in CA1 pyramidal neurons 24 hours after excitotoxic kainate treatment

homeostasis/metabolism

increased susceptibility to neuronal excitotoxicity ( J:109976 )

• Cast deficiency results in augmented DNA fragmentation in CA1 pyramidal neurons 24 hours after excitotoxic kainate treatment

cellular

increased susceptibility to neuronal excitotoxicity ( J:109976 )

• Cast deficiency results in augmented DNA fragmentation in CA1 pyramidal neurons 24 hours after excitotoxic kainate treatment

Allelic Composition	Capn2^tm1Tcs/Capn2^tm1Tcs Cast^tm1Tcs/Cast^tm1Tcs
Genetic Background	B6.129-Capn2^tm1Tcs Cast^tm1Tcs

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Capn2^tm1Tcs mutation (1 available); any Capn2 mutation (34 available)
Cast^tm1Tcs mutation (1 available); any Cast mutation (62 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

abnormal survival ( J:175868 )

• probability of survival is reduced by about 50%

Allelic Composition	Capn1^tm1Ahc/Capn1^tm1Ahc Capn2^tm1Tcs/Capn2^tm1Tcs Cast^tm1Tcs/Cast^tm1Tcs
Genetic Background	B6.129-Capn2^tm1Tcs Cast^tm1Tcs Capn1^tm1Ahc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Capn1^tm1Ahc mutation (1 available); any Capn1 mutation (33 available)
Capn2^tm1Tcs mutation (1 available); any Capn2 mutation (34 available)
Cast^tm1Tcs mutation (1 available); any Cast mutation (62 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:175868 )

• die around E11.5

cardiovascular system

hemorrhage ( J:175868 )

• detected in the trunk region

Allelic Composition	App^tm2.1Tcs/App^tm2.1Tcs Cast^tm1Tcs/Cast^tm1Tcs
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
App^tm2.1Tcs mutation (3 available); any App mutation (89 available)
Cast^tm1Tcs mutation (1 available); any Cast mutation (62 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal learning/memory/conditioning ( J:212758 )

• mice exhibit an increase in memory impairment in the Y-maze test by 3 months compared to single APP^tm2.1Tcs homozygotes

hematopoietic system

microgliosis ( J:212758 )

• microgliosis is increased compared to single APP^tm2.1Tcs homozygotes

homeostasis/metabolism

amyloidosis ( J:212758 )

• amyloid beta amyloidosis is exacerbated compared to single APP^tm2.1Tcs homozygotes

amyloid beta deposits ( J:212758 )

immune system

microgliosis ( J:212758 )

• microgliosis is increased compared to single APP^tm2.1Tcs homozygotes

nervous system

microgliosis ( J:212758 )

• microgliosis is increased compared to single APP^tm2.1Tcs homozygotes

amyloid beta deposits ( J:212758 )

astrocytosis ( J:212758 )

• astrocytosis is increased compared to single APP^tm2.1Tcs homozygotes

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