All Phenotypes Atp2b2<m1Mae> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Atp2b2^m1Mae/Atp2b2^m1Mae Pparg^tm2Mae/Pparg^tm2Mae	involves: 129S6/SvEvTac * C57BL/6J	MGI:3641262
cx2	Atp2b2^m1Mae/Atp2b2⁺ Pparg^tm2Mae/Pparg⁺	involves: 129S6/SvEvTac * C57BL/6J	MGI:3641270

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal reflex ( J:110607 )

abnormal blinking ( J:110607 )

• absent eye blink reflex

absent pinna reflex ( J:110607 )

impaired righting response ( J:110607 )

• when attempting to right themselves mice frequently fall on their side and turn onto their back with alternating flexion and hypertonic musculature of the extremities

• righting takes more than 4 sec compared to 0-1 sec in wild-type mice

absent startle reflex ( J:110607 )

• no response to acoustic stimuli

abnormal vibrissae reflex ( J:110607 )

• absent

tremors ( J:110607 )

• severe tremors seen by P12

abnormal motor coordination/balance ( J:110607 )

ataxia ( J:110607 )

• evident by P12

impaired balance ( J:110607 )

• difficulty maintaining position when the cage is shaken and unable to stand on a stationary or rotating rod

decreased grip strength ( J:110607 )

• unable to grip an inverted wire

head bobbing ( J:110607 )

abnormal gait ( J:110607 )

• wobbly gait

hearing/vestibular/ear

impaired hearing ( J:110607 )

• profound hearing loss

growth/size/body

decreased body size ( J:110607 )

• adults are about half the size of control littermates

postnatal growth retardation ( J:110607 )

• begin to lag behind littermates around P10

nervous system

abnormal prepulse inhibition ( J:110607 )

• absent

Allelic Composition	Atp2b2^m1Mae/Atp2b2⁺ Pparg^tm2Mae/Pparg⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp2b2^m1Mae mutation (0 available); any Atp2b2 mutation (66 available)
Pparg^tm2Mae mutation (0 available); any Pparg mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

impaired hearing ( J:110607 )

• severe hearing loss

behavior/neurological

decreased startle reflex ( J:110607 )

• decreased acoustic startle amplitude but normal movement and motor function

nervous system

abnormal prepulse inhibition ( J:110607 )

• absent

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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