Atp2b2^m1Mae
Spontaneous Allele Detail

Summary

• Symbol: Atp2b2^m1Mae
• Name: ATPase, Ca++ transporting, plasma membrane 2; mutation 1, Nobuyo Maeda
• MGI ID: MGI:3641249
• Synonyms: T692K
• Gene: Atp2b2 Location: Chr6:113720803-114019574 bp, - strand Genetic Position: Chr6, 52.85 cM
• Alliance: Atp2b2^m1Mae page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:110607
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Spontaneous (Null/knockout)
• Mutation: Single point mutation
• Mutation details: A C to A transversion is located at nucleotide 2075 in exon 13 resulting in a Thr to Lys substitution at position 629. This mutation was found in YTC-1 cells used to generate a line of Pparg^tm2Mae mice, but not in YTC-2 cells used to generate a second line of the same targeted mutation. (J:110607)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atp2b2 Mutation: 65 strains or lines available

References

• Original: J:110607 Tsai YS, et al., A de novo deafwaddler mutation of Pmca2 arising in ES cells and hitchhiking with a targeted modification of the Pparg gene. Mamm Genome. 2006 Jul;17(7):716-22
• All: 1 reference(s)