All Phenotypes Tyr<c-Brd> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tyr^c-Brd
albino, Allan Bradley
MGI:3640303

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tyr^c-Brd/Tyr^c-Brd	C57BL/6Brd-Tyr^c-Brd	MGI:3692731
cn2	Gt(ROSA)26Sor^tm2Thl/Gt(ROSA)26Sor⁺ Pten^tm1Hwu/Pten^tm1Hwu Trp53^tm1Thl/Trp53^tm1Thl Tyr^c-Brd/Tyr^c-Brd	involves: 129/Sv * 129S4/SvJae * C57BL/6	MGI:5008634
cn3	Gt(ROSA)26Sor^tm2Thl/Gt(ROSA)26Sor⁺ Pten^tm1Hwu/Pten^tm1Hwu Tyr^c-Brd/Tyr^c-Brd	involves: 129/Sv * 129S4/SvJae * C57BL/6	MGI:5008633
cn4	Gt(ROSA)26Sor^tm2Thl/Gt(ROSA)26Sor⁺ Tyr^c-Brd/Tyr^c-Brd	involves: 129/Sv * C57BL/6	MGI:5008632
cx5	Dp(11Cops3-Rnf112)1Jrl/0 Tyr^c-Brd/Tyr^c-Brd	B6Brd.Cg-Tyr^c-Brd Dp(11Cops3-Rnf112)1Jrl	MGI:3758726
cx6	Lgi1^tm1.1Jkc/Lgi1^tm1.1Jkc Tyr^c-Brd/Tyr^c-Brd	B6.Cg-Tyr^c-Brd Lgi1^tm1.1Jkc	MGI:4440340
cx7	Lgi1^tm1.1Jkc/Lgi1⁺ Tyr^c-Brd/Tyr^c-Brd	B6.Cg-Tyr^c-Brd Lgi1^tm1.1Jkc	MGI:4440616
cx8	In(11Trp53;11Wnt3)8Brd/+ Tyr^c-Brd/Tyr^c-Brd	involves: 129S7/SvEvBrd * C57BL/6Brd	MGI:5766501

Allelic Composition	Tyr^c-Brd/Tyr^c-Brd
Genetic Background	C57BL/6Brd-Tyr^c-Brd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyr^c-Brd mutation (8 available); any Tyr mutation (382 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

absent coat pigmentation ( J:115976 )

• the hair coat of homozygous mutant mice is entirely white

absent skin pigmentation ( J:115976 )

• the skin of homozygous mutant mice is pink in both furred and unfurred (e.g., tail, ear pinnae, feet) regions

decreased eye pigmentation ( J:115976 )

• the eyes of homozygous mutant mice are pink

vision/eye

decreased eye pigmentation ( J:115976 )

• the eyes of homozygous mutant mice are pink

integument

absent coat pigmentation ( J:115976 )

• the hair coat of homozygous mutant mice is entirely white

absent skin pigmentation ( J:115976 )

• the skin of homozygous mutant mice is pink in both furred and unfurred (e.g., tail, ear pinnae, feet) regions

Allelic Composition	Gt(ROSA)26Sor^tm2Thl/Gt(ROSA)26Sor⁺ Pten^tm1Hwu/Pten^tm1Hwu Trp53^tm1Thl/Trp53^tm1Thl Tyr^c-Brd/Tyr^c-Brd
Genetic Background	involves: 129/Sv * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm2Thl mutation (0 available); any Gt(ROSA)26Sor mutation (1046 available)
Pten^tm1Hwu mutation (17 available); any Pten mutation (86 available)
Trp53^tm1Thl mutation (0 available); any Trp53 mutation (238 available)
Tyr^c-Brd mutation (8 available); any Tyr mutation (382 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:172585 )

• median survival is 27 days following injection of PDGF and cre compared with 85 days for similarly treated Pten^tm1Hwu homozygotes

neoplasm

increased tumor growth/size ( J:172585 )

• following injection of PDGF and cre, tumor growth is increased compared to in similarly treated Pten^tm1Hwu homozygotes

increased glioblastoma incidence ( J:172585 )

• following injection of PDGF and cre, all mice develop glioblastoma composed of oligodendrocyte progenitor cells

nervous system

increased glioblastoma incidence ( J:172585 )

• following injection of PDGF and cre, all mice develop glioblastoma composed of oligodendrocyte progenitor cells

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
glioblastoma proneural subtype		DOID:0050804		J:172585

Allelic Composition	Gt(ROSA)26Sor^tm2Thl/Gt(ROSA)26Sor⁺ Pten^tm1Hwu/Pten^tm1Hwu Tyr^c-Brd/Tyr^c-Brd
Genetic Background	involves: 129/Sv * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm2Thl mutation (0 available); any Gt(ROSA)26Sor mutation (1046 available)
Pten^tm1Hwu mutation (17 available); any Pten mutation (86 available)
Tyr^c-Brd mutation (8 available); any Tyr mutation (382 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:172585 )

• median survival is 85 days following injection of PDGF and cre compared with 27 days for similarly treated Pten^tm1Hwu Trp53^tm1Thl double homozygotes

neoplasm

increased glioblastoma incidence ( J:172585 )

• following injection of PDGF and cre, all mice develop glioblastoma composed of oligodendrocyte progenitor cells

nervous system

increased glioblastoma incidence ( J:172585 )

• following injection of PDGF and cre, all mice develop glioblastoma composed of oligodendrocyte progenitor cells

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
glioblastoma proneural subtype		DOID:0050804		J:172585

Allelic Composition	Gt(ROSA)26Sor^tm2Thl/Gt(ROSA)26Sor⁺ Tyr^c-Brd/Tyr^c-Brd
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm2Thl mutation (0 available); any Gt(ROSA)26Sor mutation (1046 available)
Tyr^c-Brd mutation (8 available); any Tyr mutation (382 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:172585 )

N	• following injection of PDGF and cre, mice do not develop tumor-related morbidity

neoplasm

neoplasm ( J:172585 )

N	• following injection of PDGF and cre, mice do not develop tumor-related morbidity

Allelic Composition	Dp(11Cops3-Rnf112)1Jrl/0 Tyr^c-Brd/Tyr^c-Brd
Genetic Background	B6Brd.Cg-Tyr^c-Brd Dp(11Cops3-Rnf112)1Jrl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dp(11Cops3-Rnf112)1Jrl mutation (1 available); any Dp(11Cops3-Rnf112)1Jrl mutation (1 available)
Tyr^c-Brd mutation (8 available); any Tyr mutation (382 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal contextual conditioning behavior ( J:114996 )

• mice exhibit impaired contextual conditioning (12.6+/-2.5% freezing to context compared to 36.0+/-6.5 in wild-type mice)

decreased exploration in new environment ( J:114996 )

• mice exhibit decreased center to total distance ratio explored (0.26+/-0.01 compared to 0.33+/-0.04 in wild-type mice)

increased anxiety-related response ( J:138598 )

• in an elevated plus maze

decreased vertical activity ( J:114996 )

• mice exhibit decreased vertical activity (305+/-22 incidents compared to 499+/-60 incidences in wild-type mice)

hyperactivity ( J:114996 )

abnormal social/conspecific interaction behavior ( J:138598 )

• mice exhibit increased dominance compared with wild-type mice

• however, mice exhibit normal aggression

abnormal nest building behavior ( J:138598 )

• 6.5 hours after introducing a paper towel to cages, only half of mice build nest compared with all wild-type mice

abnormal social investigation ( J:138598 )

• mice exhibit impaired sociability and response to social novelty compared with wild-type mice

decreased vocalization ( J:138598 )

• only half of mice vocalize during handling compared with all wild-type mice

nervous system

decreased brain weight ( J:138598 )

• at 12 weeks

growth/size/body

decreased body weight ( J:138598 )

• at 12 weeks

adipose tissue

decreased abdominal fat pad weight ( J:138598 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Potocki-Lupski syndrome		DOID:0060853	OMIM:610883	J:138598

Allelic Composition	Lgi1^tm1.1Jkc/Lgi1^tm1.1Jkc Tyr^c-Brd/Tyr^c-Brd
Genetic Background	B6.Cg-Tyr^c-Brd Lgi1^tm1.1Jkc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgi1^tm1.1Jkc mutation (1 available); any Lgi1 mutation (31 available)
Tyr^c-Brd mutation (8 available); any Tyr mutation (382 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:158715 )

• at 12 to 20 days of age, mice exhibit myoclonic seizures accompanied by rapid jumping and running and die shortly after

nervous system

nervous system phenotype ( J:158715 )

N	• mice exhibit normal miniature inhibitory postsynaptic current frequency and amplitude and inhibitory postsynaptic currents

seizures ( J:158715 )

• mice exhibit an increase in spontaneous epileptiform discharge compared with wild-type mice

• however, firing frequency and spikes as well as resting membrane potential are normal

clonic seizures ( J:158715 )

• at 12 to 20 days of age, mice exhibit myoclonic seizures unlike wild-type mice accompanied by rapid jumping and running and die shortly after

enhanced AMPA-mediated synaptic currents ( J:158715 )

• AMPA receptor-mediated excitatory postsynaptic currents are larger than in wild-type mice

enhanced NMDA-mediated synaptic currents ( J:158715 )

• NMDA receptor-mediated excitatory postsynaptic currents are larger than in wild-type mice

increased miniature excitatory postsynaptic current frequency ( J:158715 )

• mice exhibit increased frequency of miniature excitatory postsynaptic currents compared with wild-type mice

growth/size/body

decreased body size ( J:158715 )

• slight in some mice

behavior/neurological

seizures ( J:158715 )

• mice exhibit an increase in spontaneous epileptiform discharge compared with wild-type mice

• however, firing frequency and spikes as well as resting membrane potential are normal

clonic seizures ( J:158715 )

• at 12 to 20 days of age, mice exhibit myoclonic seizures unlike wild-type mice accompanied by rapid jumping and running and die shortly after

pigmentation

abnormal coat/hair pigmentation ( J:158715 )

• mice exhibit cream-colored coats compared to the white-coated C57BL/6-Tyr^c-Brd control mice

abnormal eye pigmentation ( J:158715 )

• mice exhibit dark ruby eyes compared with the pink-eyed C57BL/6-Tyr^c-Brd control mice

vision/eye

abnormal eye pigmentation ( J:158715 )

• mice exhibit dark ruby eyes compared with the pink-eyed C57BL/6-Tyr^c-Brd control mice

integument

abnormal coat/hair pigmentation ( J:158715 )

• mice exhibit cream-colored coats compared to the white-coated C57BL/6-Tyr^c-Brd control mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
familial temporal lobe epilepsy 1		DOID:0060748	OMIM:600512	J:158715

Allelic Composition	Lgi1^tm1.1Jkc/Lgi1⁺ Tyr^c-Brd/Tyr^c-Brd
Genetic Background	B6.Cg-Tyr^c-Brd Lgi1^tm1.1Jkc

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

absent coat pigmentation ( J:158715 )

• due to the C57BL/6-Tyr^c-Brd background

abnormal eye pigmentation ( J:158715 )

• mice exhibit dark ruby eyes compared with the pink-eyed C57BL/6-Tyr^c-Brd control mice

vision/eye

abnormal eye pigmentation ( J:158715 )

• mice exhibit dark ruby eyes compared with the pink-eyed C57BL/6-Tyr^c-Brd control mice

integument

absent coat pigmentation ( J:158715 )

• due to the C57BL/6-Tyr^c-Brd background

Allelic Composition	In(11Trp53;11Wnt3)8Brd/+ Tyr^c-Brd/Tyr^c-Brd
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6Brd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
In(11Trp53;11Wnt3)8Brd mutation (1 available); any In(11Trp53;11Wnt3)8Brd mutation (4 available)
Tyr^c-Brd mutation (8 available); any Tyr mutation (382 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

pigmentation phenotype ( J:56548 )

N	• the inversion has no effect on coat color in an albino background, suggesting the tyrosinase minigene in the Trp53 gene is inactive in the inversion chromosome.

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