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Allele Symbol Allele Name Allele ID |
Kmt2btm1.1Afst targeted mutation 1.1, A Francis Stewart MGI:3623310 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• very few follicles at 36 weeks old
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• a higher number of primary growing follicles at 2 weeks old
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• a 50% decrease in primordial follicles at 3 weeks old
• an 80% reduction in primordial follicles at 8 weeks old
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• increase in growing preantral follicles at 3 weeks old
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• increased number of atretic follicles from 3 week of age onwards
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• a higher number of primary growing follicles at 2 weeks old
• a 50% decrease in primordial follicles and an increase in growing preantral follicles at 3 weeks old
• an 80% reduction in primordial follicles at 8 weeks old
• increased number of atretic follicles from 3 week of age onwards
• very few follicles at 36 weeks old
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• a small but significant fraction remains arrested in meiosis I in cultured peri-ovulatory oocytes for in vitro oocyte maturation studies
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• reduced ovulation rates in 3-week-old superovulated females
• trapped oocytes in luteinizing structures in hormonally stimulated females
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• decreased serum estradiol levels at 8 weeks old
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• increased serum FSH levels at 8 weeks old
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• increased serum LH levels at 8 weeks old
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• increased H4K12 acetylation
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• increased mono-methylated H3K4 in oocytes
• decreased bi- and tri-methylated H3K4 in oocytes
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• fail to establish transcriptional repression
• 80% of the oocytes are still transcriptionally active at the peri-ovulatory stage
• normal nucleolus configuration
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• very few follicles at 36 weeks old
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• a higher number of primary growing follicles at 2 weeks old
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• a 50% decrease in primordial follicles at 3 weeks old
• an 80% reduction in primordial follicles at 8 weeks old
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• increase in growing preantral follicles at 3 weeks old
|
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• increased number of atretic follicles from 3 week of age onwards
|
|
|
• a higher number of primary growing follicles at 2 weeks old
• a 50% decrease in primordial follicles and an increase in growing preantral follicles at 3 weeks old
• an 80% reduction in primordial follicles at 8 weeks old
• increased number of atretic follicles from 3 week of age onwards
• very few follicles at 36 weeks old
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• increased number of secondary and preantral follicles at 3 weeks old
• decreased number of preantral follicles at 8 weeks old
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• decreased number of primordial follicles at 3 and 8 weeks old
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• increased number of atretic follicles at 8 weeks old
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• trapped oocytes in luteinizing structures in hormonally stimulated females
• reduced ovulation rates (20%-25% of control rates) in 3-week-old superovulated females
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• embryos generated from matings of mutant females and wild-type males become developmentally arrested between the 1-cell and 4-cell stages
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• increased mono-methylated H3K4 in oocytes
• decreased tri-methylated H3K4 in oocytes
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• increased serum FSH levels at 8 weeks old
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• increased number of secondary and preantral follicles at 3 weeks old
• decreased number of preantral follicles at 8 weeks old
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• decreased number of primordial follicles at 3 and 8 weeks old
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• increased number of atretic follicles at 8 weeks old
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• tamoxifen-treated mice exhibit normal glucose homeostasis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• decreased number of primordial, primary, secondary and preantral follicles at 36 weeks old
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• increased number of atretic follicles at 36 weeks of age
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• a small reduction in fertility
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• 50% decrease in global tri-methylated H3K4 levels in granulosa cells
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• increased serum FSH levels at 8 weeks old
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• decreased number of primordial, primary, secondary and preantral follicles at 36 weeks old
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• increased number of atretic follicles at 36 weeks of age
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• tamoxifen treatment provokes infertility in females regardless of genotype
• after treatment is discontinued, control animals fully recover fertility, whereas mutant females remain infertile
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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