All Phenotypes Dnmt3b<tm1Jae> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dnmt3b^tm1Jae
targeted mutation 1, Rudolf Jaenisch
MGI:3623148

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Apc^Min/Apc⁺ Dnmt3b^tm1Jae/Dnmt3b^tm1Jae Tg(Fabp1-cre)1Jig/0	involves: 129 * C57BL/6 * C57BL/6J * FVB/N	MGI:3625330

Allelic Composition	Apc^Min/Apc⁺ Dnmt3b^tm1Jae/Dnmt3b^tm1Jae Tg(Fabp1-cre)1Jig/0
Genetic Background	involves: 129 * C57BL/6 * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (154 available)
Dnmt3b^tm1Jae mutation (1 available); any Dnmt3b mutation (50 available)
Tg(Fabp1-cre)1Jig mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor incidence ( J:107386 )

• significant decrease in the formation of macroscopic colonic adenomas in Apc^Min/+ mice

• no impact on microadenoma formation

• no noticeable effect on later stages of tumor growth

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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