Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm1(Pck1-cre)Vhh mutation
(0 available);
any
Hprt1 mutation
(1274 available)
Mioxtm1Ysk mutation
(0 available);
any
Miox mutation
(37 available)
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homeostasis/metabolism
growth/size/body
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dicer1tm1Bdh mutation
(4 available);
any
Dicer1 mutation
(94 available)
Hprt1tm1(Pck1-cre)Vhh mutation
(0 available);
any
Hprt1 mutation
(1274 available)
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renal/urinary system
N |
• mice exhibit normal kidney size, renal histology, and renal function throughout a 6-month observation period
• at 8-10 weeks of age, BUN levels and serum creatinine levels are normal relative to those in wild-type controls
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• following bilateral kidney ischemia/reperfusion injury, mice exhibit decreased creatinine plasma levels, significantly less cortical and outer medulla tubular damage, lower tubular apoptosis, and improved survival relative to wild-type controls
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homeostasis/metabolism
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1.1Cof mutation
(0 available);
any
Agtr1a mutation
(40 available)
Hprt1tm1(Pck1-cre)Vhh mutation
(0 available);
any
Hprt1 mutation
(1274 available)
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cardiovascular system
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• decreased during both the night and day
• responses to high salt diet and vasoconstrictors are similar to wild-type controls
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renal/urinary system
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• absolute rates of proximal fluid reabsorption are reduced
• fractional reabsorption rates, corrected for single nephron glomerular filtration rate, are reduced
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• decrease in single nephron glomerular filtration rate in the proximal tubules
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homeostasis/metabolism
renal/urinary system
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• pockets of inflammation
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• dilated lymphatic vessels
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• unilateral and bilateral macroscopic cysts that vary in number and size are seen in 3 of 10 mice
• multiple microscopic cysts are also seen with 3 of 10 having cysts of tubular origin and 7 of 10 having cysts of glomerular origin
• cysts of both tubular and glomerular origin may occur in the same mouse
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liver/biliary system
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• cavernous hepatic hemangiomas seen in mice at 2 - 6 months of age and with increased frequency in mice older than 6 months
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cardiovascular system
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• proliferation of endothelial cells in hepatic blood vessels
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• hepatic vascular angiectasia
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neoplasm
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• cavernous hepatic hemangiomas seen in mice at 2 - 6 months of age and with increased frequency in mice older than 6 months
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hematopoietic system
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• average red blood cell count is 10.77 x 106 compared to 9.3 x 106 in controls
• develop erythrocytosis as indicated by reddening of paws and muzzle
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• hemoglobin content is 19.38 g/dl compared to 13.24 g/dl in controls
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immune system
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• pockets of inflammation
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muscle
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• hepatic vascular angiectasia
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growth/size/body
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• unilateral and bilateral macroscopic cysts that vary in number and size are seen in 3 of 10 mice
• multiple microscopic cysts are also seen with 3 of 10 having cysts of tubular origin and 7 of 10 having cysts of glomerular origin
• cysts of both tubular and glomerular origin may occur in the same mouse
|
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arnttm1Bra mutation
(0 available);
any
Arnt mutation
(62 available)
Hprt1tm1(Pck1-cre)Vhh mutation
(0 available);
any
Hprt1 mutation
(1274 available)
Vhltm1Jae mutation
(2 available);
any
Vhl mutation
(16 available)
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renal/urinary system
N |
• no macroscopic or microscopic renal cysts are detected
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liver/biliary system
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• moderate steatosis without angiectasia or endothelial cell proliferation is seen only in mutants over 9 months of age
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neoplasm
N |
• no hepatic hemangiomas are seen
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hematopoietic system
N |
• red cell count and hemoglobin levels are similar to controls
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renal/urinary system
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• after ureteral ligation, mice exhibit reduced fibrosis and inflammation compared with similarly treated Hif1atm3Rsjo/Hif1atm3Rsjo Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ mice
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• after ureteral ligation, mice exhibit reduced fibrosis and inflammation compared with similarly treated Hif1atm3Rsjo/Hif1atm3Rsjo Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ mice
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cellular
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• hypoxic primary tubular epithelial cells fails to undergo an epithelial to mesenchyme transition unlike similarly treated cells from Hif1atm3Rsjo/Hif1atm3Rsjo Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ mice
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homeostasis/metabolism
immune system
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• after ureteral ligation, mice exhibit reduced fibrosis and inflammation compared with similarly treated Hif1atm3Rsjo/Hif1atm3Rsjo Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ mice
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm1(Pck1-cre)Vhh mutation
(0 available);
any
Hprt1 mutation
(1274 available)
Vhltm1Jae mutation
(2 available);
any
Vhl mutation
(16 available)
|
|
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renal/urinary system
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• pockets of inflammation
|
|
• dilated lymphatic vessels
|
|
• unilateral and bilateral macroscopic cysts that vary in number and size are seen in 4 of 22 mice
• multiple microscopic cysts are also seen with 5 of 20 having cysts of tubular origin and 7 of 20 having cysts of glomerular origin
• cysts of both tubular and glomerular origin may occur in the same mouse
|
liver/biliary system
|
• cavernous hepatic hemangiomas seen in mice at 2 - 6 months of age and with increased frequency in mice older than 6 months
|
cardiovascular system
|
• proliferation of endothelial cells in hepatic blood vessels
|
|
• hepatic vascular angiectasia
|
neoplasm
|
• cavernous hepatic hemangiomas seen in mice at 2 - 6 months of age and with increased frequency in mice older than 6 months
|
hematopoietic system
|
• average red blood cell count is 11.7 x 106 compared to 9.3 x 106 in controls
• develop erythrocytosis as indicated by reddening of paws and muzzle
|
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• hemoglobin content is 20.05 g/dl compared to 13.24 g/dl in controls
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immune system
|
• pockets of inflammation
|
muscle
|
• hepatic vascular angiectasia
|
growth/size/body
|
• unilateral and bilateral macroscopic cysts that vary in number and size are seen in 4 of 22 mice
• multiple microscopic cysts are also seen with 5 of 20 having cysts of tubular origin and 7 of 20 having cysts of glomerular origin
• cysts of both tubular and glomerular origin may occur in the same mouse
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm1(Pck1-cre)Vhh mutation
(0 available);
any
Hprt1 mutation
(1274 available)
Tg(CAG-lacZ,-Miox)#Ysk mutation
(0 available)
|
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renal/urinary system
homeostasis/metabolism
cellular
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm1(Pck1-cre)Vhh mutation
(0 available);
any
Hprt1 mutation
(1274 available)
Pdss2tm1Dalg mutation
(0 available);
any
Pdss2 mutation
(31 available)
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renal/urinary system
N |
• kidney ultrastructure normal
• no evidence of nephritis
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homeostasis/metabolism