Phenotypes associated with this allele

• Allele Symbol: H2-K^bm1
• Allele Name: b haplotype mutation 1
• Allele ID: MGI:3618114
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	H2-K^bm1/H2-K^bm1	B6.CBy-H2-K^bm1	MGI:5314231
cx2	H2-K^bm1/H2-K^bm1 Tg(TcraTcrb)1100Mjb/?	involves: C57BL/6	MGI:3783777

Genotype
MGI:5314231

hm1

• Allelic Composition: H2-K^bm1/H2-K^bm1
• Genetic Background: B6.CBy-H2-K^bm1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased anxiety-related response ( J:55290 )

• marginally more urination and more feces in an open field test than in controls

increased grooming behavior ( J:55290 )

decreased startle reflex ( J:55290 )

• delayed acoustic startle response

abnormal stationary movement ( J:55290 )

• more slight head and body movements observed, especially for males

abnormal vocalization ( J:55290 )

• more ultrasonic vocalizations recorded

vision/eye

early eyelid opening ( J:55290 )

Genotype
MGI:3783777

cx2

• Allelic Composition: H2-K^bm1/H2-K^bm1; Tg(TcraTcrb)1100Mjb/?
• Genetic Background: involves: C57BL/6

immune system

abnormal positive T cell selection ( J:92867 )

• the transgenic TCR does not have a high affinity for the H2-K^bm1 allele leading to poor selection of T cell precursors for the CD8 single positive subset

hematopoietic system

abnormal positive T cell selection ( J:92867 )

• the transgenic TCR does not have a high affinity for the H2-K^bm1 allele leading to poor selection of T cell precursors for the CD8 single positive subset