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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rad54btm1Roka
targeted mutation 1, Roland Kanaar
MGI:3617695
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rad54btm1Roka/Rad54btm1Roka involves: 129P2/OlaHsd MGI:3618236
cx2
 		Rad54btm1Roka/Rad54btm1Roka
Rad54ltm1Jhjh/Rad54ltm1Jhjh 		involves: 129P2/OlaHsd * C57BL/6 MGI:3618235


Genotype
MGI:3618236
hm1
Allelic
Composition		 Rad54btm1Roka/Rad54btm1Roka
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad54btm1Roka mutation (0 available); any Rad54b mutation (143 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to xenobiotic induced morbidity/mortality ( J:105544 )
• mice hypersensitive to mitomycin C, 60% survival when given a 7.5mg/kg dose

cellular
increased cellular sensitivity to gamma-irradiation ( J:105544 )
• derived ES cells show a 1.5X increase in sensitivity to ionizing radiation which is not seen in the mice themselves

homeostasis/metabolism
increased susceptibility to xenobiotic induced morbidity/mortality ( J:105544 )
• mice hypersensitive to mitomycin C, 60% survival when given a 7.5mg/kg dose




Genotype
MGI:3618235
cx2
Allelic
Composition		 Rad54btm1Roka/Rad54btm1Roka
Rad54ltm1Jhjh/Rad54ltm1Jhjh
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad54btm1Roka mutation (0 available); any Rad54b mutation (143 available)
Rad54ltm1Jhjh mutation (0 available); any Rad54l mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to xenobiotic induced morbidity/mortality ( J:105544 )
• mice extremely sensitive to mitomycin C, 100% mortality when given a 7.5mg/kg dose

cellular
abnormal cell physiology ( J:105544 )
• virtually no homologous recombination occurs in derived ES cells
increased cellular sensitivity to gamma-irradiation ( J:105544 )
• derived ES cells show a 2-3X increase in sensitivity to ionizing radiation which is not seen in the mice themselves

homeostasis/metabolism
increased susceptibility to xenobiotic induced morbidity/mortality ( J:105544 )
• mice extremely sensitive to mitomycin C, 100% mortality when given a 7.5mg/kg dose

hematopoietic system
abnormal erythrocyte morphology ( J:105544 )
• much higher numbers of micronuclei after treatment with mitomycin C




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory