Phenotypes associated with this allele

• Allele Symbol: Notch2^tm2Grid
• Allele Name: targeted mutation 2, Tom Gridley
• Allele ID: MGI:3617327
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Notch2^tm2Grid/Notch2^tm2Grid	involves: 129S1/Sv * C57BL/6J	MGI:3617347
cn2	Notch2^tm2Grid/Notch2^tm3Grid Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	involves: 129S1/Sv * C57BL/6 * DBA	MGI:3778812

Genotype
MGI:3617347

hm1

• Allelic Composition: Notch2^tm2Grid/Notch2^tm2Grid
• Genetic Background: involves: 129S1/Sv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:105278 )

• none survive beyond E11.5

growth/size/body

embryonic growth retardation ( J:105278 )

• at E10.5

cardiovascular system

pericardial edema ( J:105278 )

• at E10.5

abnormal cardiovascular system physiology ( J:105278 )

• cardiovascular dysfunction at E10.5

homeostasis/metabolism

pericardial edema ( J:105278 )

• at E10.5

embryo

embryonic growth retardation ( J:105278 )

• at E10.5

Genotype
MGI:3778812

cn2

• Allelic Composition: Notch2^tm2Grid/Notch2^tm3Grid; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA

liver/biliary system

focal hepatic necrosis ( J:133171 )

abnormal bile duct morphology ( J:133171 )

• by P7 few bile ducts are present

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:133171 )

N • blood urea nitrogen levels are normal

increased circulating bilirubin level ( J:133171 )

• in some mice

increased circulating alanine transaminase level ( J:133171 )

• in some mice

increased circulating alkaline phosphatase level ( J:133171 )

• in some mice

growth/size/body

decreased body size ( J:133171 )

decreased body weight ( J:133171 )

• at 4 to 5 weeks of age, mice are 15% lighter than wild-type

• at P8 to P9, mice are 19% lighter than wild-type

endocrine/exocrine glands

abnormal bile duct morphology ( J:133171 )

• by P7 few bile ducts are present

cellular

focal hepatic necrosis ( J:133171 )