Analysis Tools
behavior/neurological
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• mice show a slight but significant decrease in sucrose preference
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• although mice show slightly higher freezing level before conditioning, mice show robust freezing behavior in postconditioning test as in wild-type mice
• however, mice show no differences in the open-field test, in social behavior, or in short-term memory during the Y-maze
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nervous system
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• K+-induced vesicle exocytosis in cortical and striatal neurons from newborns that were cultured in vitro for 18 days is reduced, indicating impaired presynaptic exocytosis
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• dendritic tree complexity of deep layer pyramidal neurons and medium spiny neurons is decreased in the prefrontal cortex and striatum, respectively
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• spine density is decreased in prefrontal cortex and striatum neurons
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• prepulse inhibition is reduced, indicating an impairment of sensorimotor gating
• although mice show a slightly larger startle response, it is not statistically significant
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cellular
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• K+-induced vesicle exocytosis in cortical and striatal neurons from newborns that were cultured in vitro for 18 days is reduced, indicating impaired presynaptic exocytosis
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| schizophrenia | DOID:5419 |
OMIM:181500 |
J:328716 | |
