Phenotypes associated with this allele
Allelic
Composition |
Fgf8tm2Mrt/Fgf8+
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Genetic
Background |
involves: 129 * C57BL/6J * DBA/2J |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf8tm2Mrt mutation
(1 available);
any
Fgf8 mutation
(18 available)
|
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nervous system
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• cerebellar size is similar to controls
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mortality/aging
|
N |
• phenotype is stated to be identical to that of Fgf8tm1.3Mrt/ Fgf8tm1.4Mrt; Nkx2-5 tm1(cre)Rjs/ Nkx2-5 + mutants; however no data are presented
|
embryo
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• at E9.5 cell proliferation in pharyngeal endoderm is reduced with cell mitotic indices decreased by 60% relative to controls
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• excessive neural crest cell death is observed in pharyngeal arch mesenchyme at E9.5
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• thinning of splanchnic mesoderm (SM) layers
• at E9.5 cell proliferation in SM is reduced with cell mitotic indices decreased by 50% relative to controls
• excessive cell death is detected from E8.5-9.5 in SM immediately distal to emerging outflow tract and in endoderm adjacent to the SM
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• excessive neural crest cell death is observed in pharyngeal arch mesenchyme at E9.5, as well as in presumptive cardiac neural crest cells in close proximity to outflow tract
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cardiovascular system
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• phenotype is stated to be identical to that of Fgf8tm1.3Mrt/ Fgf8tm1.4Mrt; Nkx2-5 tm1(cre)Rjs/ Nkx2-5 + mutants; however no data are presented
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• anterior heart field (AHF) cells are mildly reduced compared to controls, resulting in thinning of splanchnic mesoderm (SM) layers
• at E9.5 cell proliferation in SM is reduced with cell mitotic indices decreased by 50% relative to controls; excessive cell death is detected from E8.5-9.5 in SM immediately distal to emerging outflow tract and in endoderm adjacent to the SM, with excessive cell death expanding into ventral pharyngeal endoderm by E9.5 but not in SM at this stage
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craniofacial
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• at E9.5 cell proliferation in pharyngeal endoderm is reduced with cell mitotic indices decreased by 60% relative to controls
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• excessive neural crest cell death is observed in pharyngeal arch mesenchyme at E9.5
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cellular
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• indices are reduced by 50% and 60% in splanchnic mesoderm and pharyngeal endoderm at E9.5
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nervous system
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• excessive neural crest cell death is observed in pharyngeal arch mesenchyme at E9.5, as well as in presumptive cardiac neural crest cells in close proximity to outflow tract
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growth/size/body
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• excessive neural crest cell death is observed in pharyngeal arch mesenchyme at E9.5
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|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chd7Gt(XK403)Byg mutation
(0 available);
any
Chd7 mutation
(136 available)
Fgf8tm2Mrt mutation
(1 available);
any
Fgf8 mutation
(18 available)
|
|
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nervous system
|
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• cerebellar vermis aplasia present at birth
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• due to cerebellar vermis aplasia
• cerebellar hemispheres are similar in size to controls
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Analysis Tools