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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Wnt3atm1(cre)Eag
targeted mutation 1, Elizabeth A Grove
MGI:3612795
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Wnt3atm1(cre)Eag/Wnt3atm1(cre)Eag Not Specified MGI:3715645
cn2
 		Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Relnrl/Reln+
Wnt3atm1(cre)Eag/Wnt3a+ 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:4365611
cn3
 		Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Relnrl/Reln+
Trp73tm1(cre)Agof/Trp73+
Wnt3atm1(cre)Eag/Wnt3a+ 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:4365612
cn4
 		Itgb1tm1Mll/Itgb1tm1Mll
Wnt3atm1(cre)Eag/Wnt3a+ 		involves: 129X1/SvJ MGI:4947983


Genotype
MGI:3715645
hm1
Allelic
Composition		 Wnt3atm1(cre)Eag/Wnt3atm1(cre)Eag
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt3atm1(cre)Eag mutation (0 available); any Wnt3a mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:104373 )
N
• homozygous or heterozygous mice do not show any signs Wnt3a signaling from the hem, such as a shrunken dentate gyrus




Genotype
MGI:4365611
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Relnrl/Reln+
Wnt3atm1(cre)Eag/Wnt3a+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Riet mutation (0 available); any Gt(ROSA)26Sor mutation (1046 available)
Relnrl mutation (3 available); any Reln mutation (209 available)
Wnt3atm1(cre)Eag mutation (0 available); any Wnt3a mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased Cajal-Retzius cell number ( J:153209 )
• number of Cajal-Retzius cells in the cortical marginal zone is reduced by 35% at P0




Genotype
MGI:4365612
cn3
Allelic
Composition		 Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Relnrl/Reln+
Trp73tm1(cre)Agof/Trp73+
Wnt3atm1(cre)Eag/Wnt3a+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Riet mutation (0 available); any Gt(ROSA)26Sor mutation (1046 available)
Relnrl mutation (3 available); any Reln mutation (209 available)
Trp73tm1(cre)Agof mutation (0 available); any Trp73 mutation (47 available)
Wnt3atm1(cre)Eag mutation (0 available); any Wnt3a mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased Cajal-Retzius cell number ( J:153209 )
• number of Cajal-Retzius cells (CRc) in the cortical marginal zone is reduced by 84% at P0
• nearly all CRc in the hippocampal formation are ablated




Genotype
MGI:4947983
cn4
Allelic
Composition		 Itgb1tm1Mll/Itgb1tm1Mll
Wnt3atm1(cre)Eag/Wnt3a+
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb1tm1Mll mutation (1 available); any Itgb1 mutation (58 available)
Wnt3atm1(cre)Eag mutation (0 available); any Wnt3a mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:170581 )
N
• at E15.5, mice exhibit normal Caja-Retzius localization and radial glia scaffold




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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory