Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rxratm1Ipc mutation
(0 available);
any
Rxra mutation
(30 available)
Rxratm4Ipc mutation
(0 available);
any
Rxra mutation
(30 available)
Rxrbtm1Mma mutation
(0 available);
any
Rxrb mutation
(26 available)
Rxrbtm1Pcn mutation
(0 available);
any
Rxrb mutation
(26 available)
Tg(KRT14-cre/ERT2)1Ipc mutation
(1 available)
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Rxratm1Ipc/Rxratm4Ipc Rxrbtm1Mma/Rxrbtm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0 mice develop alopecia but no skin inflammation while Rxratm4Ipc/Rxratm4Ipc Rxrbtm1Pcn/Rxrbtm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0 mice show both hair loss and skin inflammation
immune system
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• at week 12, IgG and IgE levels are 5- and 4-fold higher respectively in mutants compared to wild-type
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integument
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• mice develop early hair loss observed around the eyes and the dorsal skin at weeks 3 to 5
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• phenotype of adult mutant epidermis is identical to that observed in Rargtm1Ipc newborns
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• at week 5, mice show a dense dermal hyperplasia
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• mutants show a weaker infiltration of the dermis
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• in mutants neutral lipids are distributed unevenly along the cornified layer of the epidermis
• with treatment with the Ppard agonist L165041, epidermis of adult mice is similar to control mice with lipids forming a continuous ribbon on top of the cornified layer
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• granular keratinocytes in mutants contain vesicles devoid of lamellae or with disorganized lamellae
• disorganized lamellae form aggregates at the apical pole of granular keratinocytes
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• at week 5, mice show a dense dermal hyperplasia and hyperplasic epidermis
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hematopoietic system
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• at week 12, IgG and IgE levels are 5- and 4-fold higher respectively in mutants compared to wild-type
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rxratm4Ipc mutation
(0 available);
any
Rxra mutation
(30 available)
Rxrbtm1Pcn mutation
(0 available);
any
Rxrb mutation
(26 available)
Tg(KRT14-cre/ERT2)1Ipc mutation
(1 available)
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Rxratm4Ipc/Rxratm4Ipc Rxrbtm1Pcn/Rxrbtm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0 mice develop a chronic skin inflammation
immune system
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• after weeks 2-8, mutants develop progressive splenomegaly
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• mutant ears display reddening, swelling and scaling at week 2; by week 24, all mutants have swollen and red ears and 60% have developed ulcerations and crusts in the ear
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• total WBC counts are 24500 cells in mutants compared to 9700 cells in controls; eosinophils and neutrophils are increased relative to control
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• mutants display hyperplasia of regional lymph nodes
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• at weeks 2 and 24, cervical lymph nodes are enlarged 2- and 10-fold respectively
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• adult mice develop a spontaneous dermatitis that occurs predominantly on and behind the ears, on the face, and in the neck and back regions
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hematopoietic system
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• after weeks 2-8, mutants develop progressive splenomegaly
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• total WBC counts are 24500 cells in mutants compared to 9700 cells in controls; eosinophils and neutrophils are increased relative to control
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liver/biliary system
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• at week 20, 50% of mutants have livers that are enlarged up to 2-fold
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hearing/vestibular/ear
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• mutant ears display reddening, swelling and scaling at week 2; by week 24, all mutants have swollen and red ears and 60% have developed ulcerations and crusts in the ear
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integument
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• adult mice develop a spontaneous dermatitis that occurs predominantly on and behind the ears, on the face, and in the neck and back regions
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• mutants display progressive alopecia that is obvious by 6 weeks after Tamoxifen administration at 6 weeks of age
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• infiltrated cells and dilated blood vessels are present in the dermis; by week 24, there is heavy dermal infiltrate in mutant ears
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• at week 2, ear and dorsal skin biopsies show epidermal hyperplasia; at week 12. ears exhibit high epidermal hyperplasia
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• at week 6-8, mice exhibit dry skin on the trunk
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• at week 6-8, mice exhibit scaly skin on the trunk
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• at week 6-8, small lesions are macroscopically visible on the trunk
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growth/size/body
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• at week 20, 50% of mutants have livers that are enlarged up to 2-fold
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• after weeks 2-8, mutants develop progressive splenomegaly
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rxratm4Ipc mutation
(0 available);
any
Rxra mutation
(30 available)
Rxrbtm1Pcn mutation
(0 available);
any
Rxrb mutation
(26 available)
Tg(KRT14-cre)1Ipc mutation
(0 available)
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homeostasis/metabolism
integument
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• in mutants neutral lipids are distributed unevenly along the cornified layer of the epidermis
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• granular keratinocytes in mutants contain vesicles devoid of lamellae or with disorganized lamellae
• disorganized lamellae form aggregates at the apical pole of granular keratinocytes
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• newborns have skin with glossy appearance
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rxratm1Ipc mutation
(0 available);
any
Rxra mutation
(30 available)
Rxratm4Ipc mutation
(0 available);
any
Rxra mutation
(30 available)
Rxrbtm1Mma mutation
(0 available);
any
Rxrb mutation
(26 available)
Rxrbtm1Pcn mutation
(0 available);
any
Rxrb mutation
(26 available)
Tg(KRT14-cre)1Ipc mutation
(0 available)
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integument
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• phenotype of newborn mutant epidermis is identical to that observed in Rargtm1Ipc newborns
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• in mutants neutral lipids are distributed unevenly along the cornified layer of the epidermis
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|
• granular keratinocytes in mutants contain vesicles devoid of lamellae or with disorganized lamellae
• disorganized lamellae form aggregates at the apical pole of granular keratinocytes
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• skin of newborns appears dull
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rxrbtm1Pcn mutation
(0 available);
any
Rxrb mutation
(26 available)
Tg(KRT14-cre)1Ipc mutation
(0 available)
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normal phenotype
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• no epidermal phenotype is apparent
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