Rxrb^tm1Mma
Targeted Allele Detail

Summary

• Symbol: Rxrb^tm1Mma
• Name: retinoid X receptor beta; targeted mutation 1, Manuel Mark
• MGI ID: MGI:3606210
• Synonyms: Rxrb^af2, Rxrb^af2o
• Gene: Rxrb Location: Chr17:34250786-34257373 bp, + strand Genetic Position: Chr17, 17.98 cM
• Alliance: Rxrb^tm1Mma page

Rxra^tm1Ipc/Rxra^tm4Ipc Rxrb^tm1Mma/Rxrb^tm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0 mice develop alopecia but no skin inflammation while Rxra^tm4Ipc/Rxra^tm4Ipc Rxrb^tm1Pcn/Rxrb^tm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0 mice show both hair loss and skin inflammation

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101966
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace the 46 nucleotides encoding alpha-helix 12 that contains the AF-2 AD core with 3 stop codons, thereby creating a protein truncated at amino acid 502. Northern blot demonstrated expression of a truncated mRNA. (J:101966)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rxrb Mutation: 26 strains or lines available

References

• Original: J:101966 Mascrez B, et al., Ligand-dependent contribution of RXRbeta to cholesterol homeostasis in Sertoli cells. EMBO Rep. 2004 Mar;5(3):285-90
• All: 4 reference(s)