Phenotypes associated with this allele

• Allele Symbol: Mc5r^tm1Cone
• Allele Name: targeted mutation 1, Roger D Cone
• Allele ID: MGI:3606007
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mc5r^tm1Cone/Mc5r^tm1Cone	B6.129S4-Mc5r^tm1Cone	MGI:3606883
hm2	Mc5r^tm1Cone/Mc5r^tm1Cone	involves: 129S4/SvJaeSor * 129S6/SvEvTac	MGI:3606881

Genotype
MGI:3606883

hm1

• Allelic Composition: Mc5r^tm1Cone/Mc5r^tm1Cone
• Genetic Background: B6.129S4-Mc5r^tm1Cone

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal Harderian gland porphyrin secretion ( J:44727 )

• little or no porphyrin synthesis in response to restraint stress

behavior/neurological

decreased aggression towards male mice ( J:101848 )

• homozygous males are less aggressive and more defensive when paired with wildtype males, however social and nonsocial behaviors are unaltered and levels of aggression and defense are unaltered when paired with gonadectomized opponents or with other homozygous males

• homozygous males exhibit even less aggression and more defense in the dark phase when paired with wildtype males

• aggressive behavior is not elevated in homozygous males during the dark phase as it is in wildtype

Genotype
MGI:3606881

hm2

• Allelic Composition: Mc5r^tm1Cone/Mc5r^tm1Cone
• Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

homeostasis/metabolism

impaired adaptive thermogenesis ( J:44727 )

• core body temperature decreases more during swimming at 32 degrees Celcius and takes a longer time to return to baseline compared to controls

• when challenged with cold air, homozygotes undergo mild hypothermia, while controls increase core temperature and maintain the higher temperature for at least 3 hours

endocrine/exocrine glands

abnormal sebaceous lipid secretion ( J:44727 )

• reduction in sterol esters in sebum

abnormal lacrimal gland physiology ( J:44727 )

• do not observe melanocortin-stimulated protein secretion as in wildtype

abnormal Harderian gland porphyrin secretion ( J:44727 )

• little or no porphyrin synthesis from Harderian gland

vision/eye

abnormal lacrimal gland physiology ( J:44727 )

• do not observe melanocortin-stimulated protein secretion as in wildtype

integument

abnormal sebaceous lipid secretion ( J:44727 )

• reduction in sterol esters in sebum

abnormal coat/ hair morphology ( J:44727 )

• absorb almost twice as much water as wildtype and need more time for fur to dry after swimming due to impaired water repulsion

• decrease in hair lipid content indicated by a 15-20% reduction in acetone-extractable materials from hair