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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rps20+
wild type
MGI:3605364
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Rps20Mhdadsk4/Rps20+ C3HeB/FeJ-Rps20Mhdadsk4/Ieg MGI:2681790
ht2
 		Rps20em1(IMPC)Bay/Rps20+ C57BL/6N-Rps20em1(IMPC)Bay/BayMmucd MGI:7317062
cx3
 		Rps20Mhdadsk4/Rps20+
Trp53tm1Tyj/Trp53+ 		involves: 129S2/SvPas * C3HeB/FeJ MGI:6260021
cx4
 		Rps20Mhdadsk4/Rps20+
Tg(Dct-lacZ)A12Jkn/0 		involves: C3HeB/FeJ * C57BL/6 * CBA MGI:6259997


Genotype
MGI:2681790
ht1
Allelic
Composition		 Rps20Mhdadsk4/Rps20+
Genetic
Background		 C3HeB/FeJ-Rps20Mhdadsk4/Ieg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps20Mhdadsk4 mutation (1 available); any Rps20 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
increased ear pigmentation ( J:139244 )
• increased ear pigmentation is seen by 3 weeks of age and persists throughout adult life
abnormal epidermal pigmentation ( J:139244 )
• adults show excess epidermal pigmentation in the footpads, tail and ears
increased foot pad pigmentation ( J:86685 , J:139244 )
• excess pigment with a brown hue distributed in small patches on all or most of the volar pads identifiable at approximately 6 weeks of age (J:86685)
• increased footpad pigmentation is seen by 3 weeks of age and persists throughout adult life; pigment accumulates in the footpad epidermis (J:139244)
• Kitl (kit ligand) mRNA levels are increased in the footpad epidermis relative to control mice (J:139244)
• increased Trp53 staining is noted in the adult footpad epidermis relative to control mice (J:139244)
increased tail pigmentation ( J:139244 )
• increased tail pigmentation is seen by 3 weeks of age and persists throughout adult life
• pigment accumulates in the adult tail epidermis, whereas the dermis is unaffected

integument
increased ear pigmentation ( J:139244 )
• increased ear pigmentation is seen by 3 weeks of age and persists throughout adult life
abnormal epidermal pigmentation ( J:139244 )
• adults show excess epidermal pigmentation in the footpads, tail and ears
increased foot pad pigmentation ( J:86685 , J:139244 )
• excess pigment with a brown hue distributed in small patches on all or most of the volar pads identifiable at approximately 6 weeks of age (J:86685)
• increased footpad pigmentation is seen by 3 weeks of age and persists throughout adult life; pigment accumulates in the footpad epidermis (J:139244)
• Kitl (kit ligand) mRNA levels are increased in the footpad epidermis relative to control mice (J:139244)
• increased Trp53 staining is noted in the adult footpad epidermis relative to control mice (J:139244)
increased tail pigmentation ( J:139244 )
• increased tail pigmentation is seen by 3 weeks of age and persists throughout adult life
• pigment accumulates in the adult tail epidermis, whereas the dermis is unaffected

limbs/digits/tail
increased foot pad pigmentation ( J:86685 , J:139244 )
• excess pigment with a brown hue distributed in small patches on all or most of the volar pads identifiable at approximately 6 weeks of age (J:86685)
• increased footpad pigmentation is seen by 3 weeks of age and persists throughout adult life; pigment accumulates in the footpad epidermis (J:139244)
• Kitl (kit ligand) mRNA levels are increased in the footpad epidermis relative to control mice (J:139244)
• increased Trp53 staining is noted in the adult footpad epidermis relative to control mice (J:139244)
increased tail pigmentation ( J:139244 )
• increased tail pigmentation is seen by 3 weeks of age and persists throughout adult life
• pigment accumulates in the adult tail epidermis, whereas the dermis is unaffected

growth/size/body
increased ear pigmentation ( J:139244 )
• increased ear pigmentation is seen by 3 weeks of age and persists throughout adult life

craniofacial
increased ear pigmentation ( J:139244 )
• increased ear pigmentation is seen by 3 weeks of age and persists throughout adult life

hearing/vestibular/ear
increased ear pigmentation ( J:139244 )
• increased ear pigmentation is seen by 3 weeks of age and persists throughout adult life




Genotype
MGI:7317062
ht2
Allelic
Composition		 Rps20em1(IMPC)Bay/Rps20+
Genetic
Background		 C57BL/6N-Rps20em1(IMPC)Bay/BayMmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps20em1(IMPC)Bay mutation (1 available); any Rps20 mutation (12 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological




Genotype
MGI:6260021
cx3
Allelic
Composition		 Rps20Mhdadsk4/Rps20+
Trp53tm1Tyj/Trp53+
Genetic
Background		 involves: 129S2/SvPas * C3HeB/FeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps20Mhdadsk4 mutation (1 available); any Rps20 mutation (12 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (249 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
pigmentation phenotype ( J:139244 )
N
• adult mice exhibit reversal of the hyperpigmentation phenotype seen in the footpad and tail skin of single Rps20Mhdadsk4 heterozygotes




Genotype
MGI:6259997
cx4
Allelic
Composition		 Rps20Mhdadsk4/Rps20+
Tg(Dct-lacZ)A12Jkn/0
Genetic
Background		 involves: C3HeB/FeJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps20Mhdadsk4 mutation (1 available); any Rps20 mutation (12 available)
Tg(Dct-lacZ)A12Jkn mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
abnormal epidermal melanocyte morphology ( J:139244 )
• an increased number of Xgal+ cells (melanocytes) are first detected in the basal layer of the footpad epidermis at P3 and persist in the adult footpad, indicating postnatal epidermal melanocytosis
increased melanocyte number ( J:139244 )
• an increased number of Xgal+ cells (melanocytes) are first detected in the basal layer of the footpad epidermis at P3 and persist in the adult footpad

integument
abnormal epidermal melanocyte morphology ( J:139244 )
• an increased number of Xgal+ cells (melanocytes) are first detected in the basal layer of the footpad epidermis at P3 and persist in the adult footpad, indicating postnatal epidermal melanocytosis

embryo
abnormal melanoblast morphology ( J:139244 )
• a decreased number of Xgal+ cells (melanoblasts) is observed at E15.5 and other embryonic time points
• a ventral surface area devoid of Xgal+ cells is observed at E15.5

nervous system
abnormal melanoblast morphology ( J:139244 )
• a decreased number of Xgal+ cells (melanoblasts) is observed at E15.5 and other embryonic time points
• a ventral surface area devoid of Xgal+ cells is observed at E15.5




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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory