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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Hcrtr1tm1Dgen
targeted mutation 1, Deltagen
MGI:3604598
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Hcrtr1tm1Dgen/Hcrtr1tm1Dgen B6.129P2-Hcrtr1tm1Dgen/J MGI:5610038
hm2
Hcrtr1tm1Dgen/Hcrtr1tm1Dgen involves: 129P2/OlaHsd * C57BL/6 MGI:3606521


Genotype
MGI:5610038
hm1
Allelic
Composition
Hcrtr1tm1Dgen/Hcrtr1tm1Dgen
Genetic
Background
B6.129P2-Hcrtr1tm1Dgen/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hcrtr1tm1Dgen mutation (1 available); any Hcrtr1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• significantly lower cocaine self administration (J:208627)
• treatment with SB334867 partially restores cocaine self-administration (J:208627)
• significantly lower cocaine self administration across a broad range of doses (J:216923)
• however, response to food rewards is similar to wild-type controls (J:216923)
• significantly lower cocaine self administration (J:208627)
• treatment with SB334867 partially restores cocaine self-administration (J:208627)
• significantly lower cocaine self administration across a broad range of doses (J:216923)
• however, response to food rewards is similar to wild-type controls (J:216923)




Genotype
MGI:3606521
hm2
Allelic
Composition
Hcrtr1tm1Dgen/Hcrtr1tm1Dgen
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hcrtr1tm1Dgen mutation (1 available); any Hcrtr1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• homozygotes require a lower dose of metrazol to induce various seizure stages compared to wild-type mice

nervous system
• homozygotes require a lower dose of metrazol to induce various seizure stages compared to wild-type mice





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/24/2023
MGI 6.22
The Jackson Laboratory