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Targeted Allele Detail
Symbol: Hcrtr1tm1Dgen
Name: hypocretin (orexin) receptor 1; targeted mutation 1, Deltagen
MGI ID: MGI:3604598
Gene: Hcrtr1  Location: Chr4:130024010-130033152 bp, - strand  Genetic Position: Chr4, 63.43 cM
Alliance: Hcrtr1tm1Dgen page
Mutant Cell Line:  5353
Germline Transmission:  Earliest citation of germline transmission: J:101679
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Project Collection: Deltagen
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Disruption caused by insertion of vector
Mutation detailsA bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. RT-PCR analysis detects a gene transcript in brain, spinal cord, pancreas, lymph nodes, skin, urinary bladder, pituitary gland, adrenal gland, small intestine and prostate gland and at lower levels in olfactory bulb, lung, liver, kidney, spleen, bone marrow, gallbladder, stomach, colon, testis, seminal vesicle, coagulating gland, ovary, uterus and white fat; beta-galactosidase expression is detectable in urinary bladder and a few cells in the muscularis, but not in brain, spinal cord, sciatic nerve, eyes, thymus, spleen, lymph nodes, bone marrow, aorta, heart, lung, liver, pancreas, kidney, thyroid gland, pituitary gland, adrenal glands, skeletal muscle, skin, testis, prostate gland, ovary, uterus and cervix.
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 35 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hcrtr1 Mutation:  22 strains or lines available
See also, data as provided by Deltagen, Inc.
Original:  J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005;
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory