All Phenotypes Gria3<tm1Dgen> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gria3^tm1Dgen
targeted mutation 1, Deltagen
MGI:3604486

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gria3^tm1Dgen/Gria3^tm1Dgen	involves: 129P2/OlaHsd * C57BL/6	MGI:3606450
hm2	Gria3^tm1Dgen/Gria3^tm1Dgen	involves: 129P2/OlaHsd * C57BL/6J	MGI:3795130
cx3	Gria3^tm1Dgen/Gria3^tm1Dgen Gria4^spkw1/Gria4^spkw1	involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6J	MGI:3795127
ot4	Gria3^tm1Dgen/Y	involves: 129P2/OlaHsd * C57BL/6	MGI:3628569

Allelic Composition	Gria3^tm1Dgen/Gria3^tm1Dgen
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria3^tm1Dgen mutation (2 available); any Gria3 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:101679 )

• at 300 days of age body weight, body mass, and/or body weight to length ratios are reduced

Allelic Composition	Gria3^tm1Dgen/Gria3^tm1Dgen
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria3^tm1Dgen mutation (2 available); any Gria3 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:135814 )

N	• mice show no spike wave discharge (SWD) • with age, no ataxia is observed

Allelic Composition	Gria3^tm1Dgen/Gria3^tm1Dgen Gria4^spkw1/Gria4^spkw1
Genetic Background	involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria3^tm1Dgen mutation (2 available); any Gria3 mutation (10 available)
Gria4^spkw1 mutation (4 available); any Gria4 mutation (72 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

ataxia ( J:135814 )

• at 3 months of age, mice develop mild to moderate cerebellar ataxia compared to single mutant littermates

absence seizures ( J:135814 )

• double mutants have much lower incidence of spike wave discharge (SWD) than Gria4^spkw1 homozygotes

nervous system

absence seizures ( J:135814 )

• double mutants have much lower incidence of spike wave discharge (SWD) than Gria4^spkw1 homozygotes

Allelic Composition	Gria3^tm1Dgen/Y
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria3^tm1Dgen mutation (2 available); any Gria3 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased susceptibility to pharmacologically induced seizures ( J:101679 )

• a higher dose of metrazol is needed to induce a first twitch stage of seizure response compared to wild-type mice

decreased startle reflex ( J:101679 )

• startle response is decreased in response to high intensity sound stimuli

increased thermal nociceptive threshold ( J:101679 )

• prolonged latency in hot plate test

nervous system

decreased susceptibility to pharmacologically induced seizures ( J:101679 )

• a higher dose of metrazol is needed to induce a first twitch stage of seizure response compared to wild-type mice

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