mortality/aging
N |
• normal life span
|
renal/urinary system
N |
• normal kidney morphology and creatinine clearance
|
• decreased ammonium excretion
• reduced ability to increase urinary ammonia
|
• higher excretion of titratable acid relative to controls
• less ability to recover from high acid in the diet
|
• ammonium content of the renal papilla is reduced 30% compared to controls
|
homeostasis/metabolism
N |
• normal blood pH
• normal blood bicarbonate levels
|
• decreased ammonium excretion
• reduced ability to increase urinary ammonia
|
• higher excretion of titratable acid relative to controls
• less ability to recover from high acid in the diet
|