Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1tm8.2Sho mutation
(0 available);
any
Gata1 mutation
(44 available)
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liver/biliary system
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• authors state that mice have an identical phenotype to that found in Gata1tm7Sho homozygous females
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• authors state that mice have an identical phenotype to that found in Gata1tm7Sho homozygous females
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hematopoietic system
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• authors state that mice have an identical phenotype to that found in Gata1tm7Sho homozygous females
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• authors state that mice have an identical phenotype to that found in Gata1tm7Sho homozygous females
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dp(16Cbr1-Fam3b)1Rhr mutation
(1 available);
any
Dp(16Cbr1-Fam3b)1Rhr mutation
(1 available)
Gata1tm8.2Sho mutation
(0 available);
any
Gata1 mutation
(44 available)
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hematopoietic system
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• extensive extramedullary hematopoiesis in 6 month old mutants
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• adult mutants are mildly anemic
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• 6 month old mutants exhibit marrow fibrosis
• increase in the number of CFU-GM colonies in the bone marrow in 6 month old mutants
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• 6 month old mutants exhibit marrow fibrosis, with increased megakaryocytes present in clusters
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• increase in number of megakaryocytes in the bone marrow in 6 month old mutants
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• increase in number of CFU-Mk colonies in the bone marrow and/or spleen
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• adults develop a transient thrombocytosis
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• increase in number of monocytes in the bone marrow and/or the spleen of 6 month old mutants
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immune system
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• increase in number of monocytes in the bone marrow and/or the spleen of 6 month old mutants
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growth/size/body
Allelic Composition |
Gata1tm8.2Sho/Y
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Genetic Background |
involves: 129S1/Sv |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1tm8.2Sho mutation
(0 available);
any
Gata1 mutation
(44 available)
|
|
|
liver/biliary system
|
• authors state that mice have an identical phenotype to that found in Gata1tm7Sho heterozygous males
|
|
• authors state that mice have an identical phenotype to that found in Gata1tm7Sho heterozygous males
|
hematopoietic system
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• authors state that mice have an identical phenotype to that found in Gata1tm7Sho heterozygous males
|
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• authors state that mice have an identical phenotype to that found in Gata1tm7Sho heterozygous males
|