All Phenotypes Gata1<tm8.2Sho> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gata1^tm8.2Sho
targeted mutation 8.2, Stuart H Orkin
MGI:3582683

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gata1^tm8.2Sho/Gata1^tm8.2Sho	involves: 129S1/Sv	MGI:3716339
cx2	Dp(16Cbr1-Fam3b)1Rhr/0 Gata1^tm8.2Sho/Y	involves: 129S1/Sv * 129S6/SvEvTac	MGI:5429726
ot3	Gata1^tm8.2Sho/Y	involves: 129S1/Sv	MGI:3716338

Allelic Composition	Gata1^tm8.2Sho/Gata1^tm8.2Sho
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1^tm8.2Sho mutation (0 available); any Gata1 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

liver hypoplasia ( J:99310 )

• authors state that mice have an identical phenotype to that found in Gata1^tm7Sho homozygous females

pale liver ( J:99310 )

• authors state that mice have an identical phenotype to that found in Gata1^tm7Sho homozygous females

hematopoietic system

abnormal erythropoiesis ( J:99310 )

• authors state that mice have an identical phenotype to that found in Gata1^tm7Sho homozygous females

abnormal megakaryocyte morphology ( J:99310 )

• authors state that mice have an identical phenotype to that found in Gata1^tm7Sho homozygous females

Allelic Composition	Dp(16Cbr1-Fam3b)1Rhr/0 Gata1^tm8.2Sho/Y
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dp(16Cbr1-Fam3b)1Rhr mutation (1 available); any Dp(16Cbr1-Fam3b)1Rhr mutation (1 available)
Gata1^tm8.2Sho mutation (0 available); any Gata1 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

enlarged spleen ( J:184564 )

• in 6 month old mutants

extramedullary hematopoiesis ( J:184564 )

• extensive extramedullary hematopoiesis in 6 month old mutants

anemia ( J:184564 )

• adult mutants are mildly anemic

abnormal bone marrow cell morphology/development ( J:184564 )

• 6 month old mutants exhibit marrow fibrosis

• increase in the number of CFU-GM colonies in the bone marrow in 6 month old mutants

abnormal bone marrow cell number ( J:184564 )

• 6 month old mutants exhibit marrow fibrosis, with increased megakaryocytes present in clusters

increased megakaryocyte cell number ( J:184564 )

• increase in number of megakaryocytes in the bone marrow in 6 month old mutants

abnormal megakaryocyte progenitor cell morphology ( J:184564 )

• increase in number of CFU-Mk colonies in the bone marrow and/or spleen

thrombocytosis ( J:184564 )

• adults develop a transient thrombocytosis

increased monocyte cell number ( J:184564 )

• increase in number of monocytes in the bone marrow and/or the spleen of 6 month old mutants

immune system

enlarged spleen ( J:184564 )

• in 6 month old mutants

increased monocyte cell number ( J:184564 )

• increase in number of monocytes in the bone marrow and/or the spleen of 6 month old mutants

growth/size/body

enlarged spleen ( J:184564 )

• in 6 month old mutants

Allelic Composition	Gata1^tm8.2Sho/Y
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1^tm8.2Sho mutation (0 available); any Gata1 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

liver hypoplasia ( J:99310 )

• authors state that mice have an identical phenotype to that found in Gata1^tm7Sho heterozygous males

pale liver ( J:99310 )

• authors state that mice have an identical phenotype to that found in Gata1^tm7Sho heterozygous males

hematopoietic system

abnormal erythropoiesis ( J:99310 )

• authors state that mice have an identical phenotype to that found in Gata1^tm7Sho heterozygous males

abnormal megakaryocyte morphology ( J:99310 )

• authors state that mice have an identical phenotype to that found in Gata1^tm7Sho heterozygous males

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