Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria4spkw1 mutation
(4 available);
any
Gria4 mutation
(72 available)
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behavior/neurological
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• more frequent and longer spike wave discharges than either C3H/HeJ or B6.129P2-Gria4tm1Dgen
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nervous system
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• more frequent and longer spike wave discharges than either C3H/HeJ or B6.129P2-Gria4tm1Dgen
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria4spkw1 mutation
(4 available);
any
Gria4 mutation
(72 available)
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behavior/neurological
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• mice show higher spike wave discharge incidence than C3HeB/FeJ or C57BL/6 mice
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nervous system
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• mice show higher spike wave discharge incidence than C3HeB/FeJ or C57BL/6 mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria4spkw1 mutation
(4 available);
any
Gria4 mutation
(72 available)
|
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behavior/neurological
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• Background Sensitivity: when (C3H/HeJ x C3HeB/FeJ)F1 mice are backcrossed to C3H/HeJ mice to make the hybrids homozygous for this Gria4 mutation, the mutants show a much greater spike wave discharge (SWD) incidence than the original C3H/HeJ mice
• some animals show relatively low SWD incidence whereas some display very high SWD incidence
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nervous system
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• Background Sensitivity: when (C3H/HeJ x C3HeB/FeJ)F1 mice are backcrossed to C3H/HeJ mice to make the hybrids homozygous for this Gria4 mutation, the mutants show a much greater spike wave discharge (SWD) incidence than the original C3H/HeJ mice
• some animals show relatively low SWD incidence whereas some display very high SWD incidence
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria4spkw1 mutation
(4 available);
any
Gria4 mutation
(72 available)
|
|
|
behavior/neurological
|
• increased incidence of spike wave discharges
|
nervous system
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• increased incidence of spike wave discharges
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Allelic Composition |
Gria4spkw1/Gria4+
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Genetic Background |
involves: C3H/HeJ * C3HeB/FeJ |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria4spkw1 mutation
(4 available);
any
Gria4 mutation
(72 available)
|
|
|
behavior/neurological
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• the spike wave discharge incidence observed in the (C3H/HeJ x C3HeB/FeJ)F1 intercross is slightly lower than that observed in homozygous C3H/HeJ animals
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nervous system
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• the spike wave discharge incidence observed in the (C3H/HeJ x C3HeB/FeJ)F1 intercross is slightly lower than that observed in homozygous C3H/HeJ animals
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behavior/neurological
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• all compound mutants display a high incidence (90 SWD/hr) of spike wave discharge (SWD)
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nervous system
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• all compound mutants display a high incidence (90 SWD/hr) of spike wave discharge (SWD)
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behavior/neurological
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• incidence and length of spike wave discharges is decreased as compared to mice homozygous for Gria4spkw1 alone
• incidence and length of spike wave discharges is slightly decreased as compared to C3H/He
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nervous system
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• incidence and length of spike wave discharges is decreased as compared to mice homozygous for Gria4spkw1 alone
• incidence and length of spike wave discharges is slightly decreased as compared to C3H/He
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behavior/neurological
N |
• incidence and length of spike wave discharges is slightly, but not significantly, decreased as compared to C3H/HeJ or mice homozygous for Gria4spkw1
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria4spkw1 mutation
(4 available);
any
Gria4 mutation
(72 available)
Pcnx2em5Frk mutation
(0 available);
any
Pcnx2 mutation
(130 available)
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behavior/neurological
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• incidence and length of spike wave discharges is decreased as compared to mice homozygous for Gria4spkw1 alone
• incidence and length of spike wave discharges is slightly decreased as compared to C3H/HeJ
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nervous system
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• incidence and length of spike wave discharges is decreased as compared to mice homozygous for Gria4spkw1 alone
• incidence and length of spike wave discharges is slightly decreased as compared to C3H/HeJ
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behavior/neurological
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• at 3 months of age, mice develop mild to moderate cerebellar ataxia compared to single mutant littermates
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• double mutants have much lower incidence of spike wave discharge (SWD) than Gria4spkw1 homozygotes
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nervous system
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• double mutants have much lower incidence of spike wave discharge (SWD) than Gria4spkw1 homozygotes
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria4spkw1 mutation
(4 available);
any
Gria4 mutation
(72 available)
spkw2C3H/HeJ mutation
(0 available);
any
spkw2 mutation
(0 available)
spkw2C57BL/6J mutation
(0 available);
any
spkw2 mutation
(0 available)
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behavior/neurological
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• increased incidence of spike wave discharges
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nervous system
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• increased incidence of spike wave discharges
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