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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gria4spkw1
spike wave discharge 1
MGI:3580141
Summary 11 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gria4spkw1/Gria4spkw1 C3Fe.C3-Gria4spkw1 MGI:5818663
hm2
 		Gria4spkw1/Gria4spkw1 C3H/HeJ MGI:3795118
hm3
 		Gria4spkw1/Gria4spkw1 involves: C3H/HeJ * C3HeB/FeJ MGI:3795120
hm4
 		Gria4spkw1/Gria4spkw1 involves: C3H/HeJ * C57BL/6J MGI:3580145
ht5
 		Gria4spkw1/Gria4+ involves: C3H/HeJ * C3HeB/FeJ MGI:3795119
ht6
 		Gria4spkw1/Gria4tm1Dgen involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6J MGI:3795121
cx7
 		Gria4spkw1/Gria4spkw1
Pcnx2em1Frk/Pcnx2em1Frk 		C3Fe.C3-Pcnx2em1Frk Gria4spkw1 MGI:5818665
cx8
 		Gria4spkw1/Gria4spkw1
Pcnx2em4Frk/Pcnx2em4Frk 		C3Fe.C3-Pcnx2em4Frk Gria4spkw1 MGI:5818669
cx9
 		Gria4spkw1/Gria4spkw1
Pcnx2em5Frk/Pcnx2em5Frk 		C3Fe.C3-Pcnx2em5Frk Gria4spkw1 MGI:5818667
cx10
 		Gria3tm1Dgen/Gria3tm1Dgen
Gria4spkw1/Gria4spkw1 		involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6J MGI:3795127
cx11
 		Gria4spkw1/Gria4spkw1
spkw2C3H/HeJ/spkw2C57BL/6J 		involves: C3H/HeJ * C57BL/6J MGI:3580146


Genotype
MGI:5818663
hm1
Allelic
Composition		 Gria4spkw1/Gria4spkw1
Genetic
Background		 C3Fe.C3-Gria4spkw1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria4spkw1 mutation (3 available); any Gria4 mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal spike wave discharge ( J:228536 )
• more frequent and longer spike wave discharges than either C3H/HeJ or B6.129P2-Gria4tm1Dgen

nervous system
abnormal spike wave discharge ( J:228536 )
• more frequent and longer spike wave discharges than either C3H/HeJ or B6.129P2-Gria4tm1Dgen




Genotype
MGI:3795118
hm2
Allelic
Composition		 Gria4spkw1/Gria4spkw1
Genetic
Background		 C3H/HeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria4spkw1 mutation (3 available); any Gria4 mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
absence seizures ( J:135814 )
• mice show higher spike wave discharge incidence than C3HeB/FeJ or C57BL/6 mice

nervous system
absence seizures ( J:135814 )
• mice show higher spike wave discharge incidence than C3HeB/FeJ or C57BL/6 mice




Genotype
MGI:3795120
hm3
Allelic
Composition		 Gria4spkw1/Gria4spkw1
Genetic
Background		 involves: C3H/HeJ * C3HeB/FeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria4spkw1 mutation (3 available); any Gria4 mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
absence seizures ( J:135814 )
• Background Sensitivity: when (C3H/HeJ x C3HeB/FeJ)F1 mice are backcrossed to C3H/HeJ mice to make the hybrids homozygous for this Gria4 mutation, the mutants show a much greater spike wave discharge (SWD) incidence than the original C3H/HeJ mice
• some animals show relatively low SWD incidence whereas some display very high SWD incidence

nervous system
absence seizures ( J:135814 )
• Background Sensitivity: when (C3H/HeJ x C3HeB/FeJ)F1 mice are backcrossed to C3H/HeJ mice to make the hybrids homozygous for this Gria4 mutation, the mutants show a much greater spike wave discharge (SWD) incidence than the original C3H/HeJ mice
• some animals show relatively low SWD incidence whereas some display very high SWD incidence




Genotype
MGI:3580145
hm4
Allelic
Composition		 Gria4spkw1/Gria4spkw1
Genetic
Background		 involves: C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria4spkw1 mutation (3 available); any Gria4 mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
absence seizures ( J:98638 )
• increased incidence of spike wave discharges

nervous system
absence seizures ( J:98638 )
• increased incidence of spike wave discharges




Genotype
MGI:3795119
ht5
Allelic
Composition		 Gria4spkw1/Gria4+
Genetic
Background		 involves: C3H/HeJ * C3HeB/FeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria4spkw1 mutation (3 available); any Gria4 mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
absence seizures ( J:135814 )
• the spike wave discharge incidence observed in the (C3H/HeJ x C3HeB/FeJ)F1 intercross is slightly lower than that observed in homozygous C3H/HeJ animals

nervous system
absence seizures ( J:135814 )
• the spike wave discharge incidence observed in the (C3H/HeJ x C3HeB/FeJ)F1 intercross is slightly lower than that observed in homozygous C3H/HeJ animals




Genotype
MGI:3795121
ht6
Allelic
Composition		 Gria4spkw1/Gria4tm1Dgen
Genetic
Background		 involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria4spkw1 mutation (3 available); any Gria4 mutation (71 available)
Gria4tm1Dgen mutation (2 available); any Gria4 mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
absence seizures ( J:135814 )
• all compound mutants display a high incidence (90 SWD/hr) of spike wave discharge (SWD)

nervous system
absence seizures ( J:135814 )
• all compound mutants display a high incidence (90 SWD/hr) of spike wave discharge (SWD)




Genotype
MGI:5818665
cx7
Allelic
Composition		 Gria4spkw1/Gria4spkw1
Pcnx2em1Frk/Pcnx2em1Frk
Genetic
Background		 C3Fe.C3-Pcnx2em1Frk Gria4spkw1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria4spkw1 mutation (3 available); any Gria4 mutation (71 available)
Pcnx2em1Frk mutation (1 available); any Pcnx2 mutation (130 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal spike wave discharge ( J:228536 )
• incidence and length of spike wave discharges is decreased as compared to mice homozygous for Gria4spkw1 alone
• incidence and length of spike wave discharges is slightly decreased as compared to C3H/He

nervous system
abnormal spike wave discharge ( J:228536 )
• incidence and length of spike wave discharges is decreased as compared to mice homozygous for Gria4spkw1 alone
• incidence and length of spike wave discharges is slightly decreased as compared to C3H/He




Genotype
MGI:5818669
cx8
Allelic
Composition		 Gria4spkw1/Gria4spkw1
Pcnx2em4Frk/Pcnx2em4Frk
Genetic
Background		 C3Fe.C3-Pcnx2em4Frk Gria4spkw1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria4spkw1 mutation (3 available); any Gria4 mutation (71 available)
Pcnx2em4Frk mutation (1 available); any Pcnx2 mutation (130 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:228536 )
N
• incidence and length of spike wave discharges is slightly, but not significantly, decreased as compared to C3H/HeJ or mice homozygous for Gria4spkw1




Genotype
MGI:5818667
cx9
Allelic
Composition		 Gria4spkw1/Gria4spkw1
Pcnx2em5Frk/Pcnx2em5Frk
Genetic
Background		 C3Fe.C3-Pcnx2em5Frk Gria4spkw1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria4spkw1 mutation (3 available); any Gria4 mutation (71 available)
Pcnx2em5Frk mutation (0 available); any Pcnx2 mutation (130 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal spike wave discharge ( J:228536 )
• incidence and length of spike wave discharges is decreased as compared to mice homozygous for Gria4spkw1 alone
• incidence and length of spike wave discharges is slightly decreased as compared to C3H/HeJ

nervous system
abnormal spike wave discharge ( J:228536 )
• incidence and length of spike wave discharges is decreased as compared to mice homozygous for Gria4spkw1 alone
• incidence and length of spike wave discharges is slightly decreased as compared to C3H/HeJ




Genotype
MGI:3795127
cx10
Allelic
Composition		 Gria3tm1Dgen/Gria3tm1Dgen
Gria4spkw1/Gria4spkw1
Genetic
Background		 involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria3tm1Dgen mutation (2 available); any Gria3 mutation (12 available)
Gria4spkw1 mutation (3 available); any Gria4 mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
ataxia ( J:135814 )
• at 3 months of age, mice develop mild to moderate cerebellar ataxia compared to single mutant littermates
absence seizures ( J:135814 )
• double mutants have much lower incidence of spike wave discharge (SWD) than Gria4spkw1 homozygotes

nervous system
absence seizures ( J:135814 )
• double mutants have much lower incidence of spike wave discharge (SWD) than Gria4spkw1 homozygotes




Genotype
MGI:3580146
cx11
Allelic
Composition		 Gria4spkw1/Gria4spkw1
spkw2C3H/HeJ/spkw2C57BL/6J
Genetic
Background		 involves: C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria4spkw1 mutation (3 available); any Gria4 mutation (71 available)
spkw2C3H/HeJ mutation (0 available); any spkw2 mutation (0 available)
spkw2C57BL/6J mutation (0 available); any spkw2 mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
absence seizures ( J:98638 )
• increased incidence of spike wave discharges

nervous system
absence seizures ( J:98638 )
• increased incidence of spike wave discharges




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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory