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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rbbp8tm1Whl
targeted mutation 1, Wen-Hwa Lee
MGI:3577029
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rbbp8tm1Whl/Rbbp8tm1Whl Not Specified MGI:3577102
ht2
 		Rbbp8tm1Whl/Rbbp8+ Not Specified MGI:3577103
cn3
 		Rbbp8tm1Whl/Rbbp8tm1.1Thl
Cd19tm1(cre)Cgn/Cd19+ 		involves: 129P2/OlaHsd * 129S4/SvJaeSor MGI:5484529


Genotype
MGI:3577102
hm1
Allelic
Composition		 Rbbp8tm1Whl/Rbbp8tm1Whl
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rbbp8tm1Whl mutation (0 available); any Rbbp8 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality before implantation, complete penetrance ( J:97648 )
• homozygotes die at E4 because blastocysts fail to enter S phase

embryo
failure of blastocyst to hatch from the zona pellucida ( J:97648 )
• homozygous blastocysts in culture fail to hatch from the zona pellucida
embryonic growth arrest ( J:97648 )
• homozygous blastocysts in culture show no outgrowth
absent egg cylinders ( J:97648 )
• homozygous embryos fail to form egg cylinders and degenerate in the uterus

cellular
abnormal cell cycle ( J:97648 )
• cells from homozygous blastocysts fail to proliferate and arrest at G1




Genotype
MGI:3577103
ht2
Allelic
Composition		 Rbbp8tm1Whl/Rbbp8+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rbbp8tm1Whl mutation (0 available); any Rbbp8 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased tumor-free survival time ( J:97648 )
• heterozygotes die around day 625 with multiple tumors, wild-type littermates die around day 780

neoplasm
increased lymphoma incidence ( J:97648 )
• multiple tumors, predominantly large lymphomas of both B and T cells are seen in older heterozygotes
• tumors all retain a wild-type copy of Rbbp8




Genotype
MGI:5484529
cn3
Allelic
Composition		 Rbbp8tm1Whl/Rbbp8tm1.1Thl
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (56 available)
Rbbp8tm1.1Thl mutation (0 available); any Rbbp8 mutation (51 available)
Rbbp8tm1Whl mutation (0 available); any Rbbp8 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:194603 )
N
• B cells exhibit normal class switching and microhomology at Smu-Sgamma1 junctions




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory