Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Sirt1)Ktm mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(Agrp-cre)1Gsb mutation
(0 available)
|
|
|
growth/size/body
|
N |
• mice exhibit normal body length
• female and male mice fed a high fat high sugar diet exhibit normal body weight
|
 |
• female mice exhibit a tend toward increased body weight
|
 |
• in male mice fed normal chow
|
behavior/neurological
|
N |
• mice fed normal chow or a high fat high sugar diet exhibit normal locomotor activity
|
|
|
• in male mice fed normal chow
|
|
|
• in female mice fed normal chow
|
homeostasis/metabolism
adipose tissue
|
N |
• mice fed normal chow or a high fat high sugar diet exhibit normal adiposity
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(Sirt1)Ktm mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(Agrp-cre)1Gsb mutation
(0 available)
|
|
|
adipose tissue
|
N |
• mice fed normal chow exhibit normal epididymal white adipose tissue weight
|
behavior/neurological
|
N |
• mice fed normal chow exhibit normal food intake and locomotor activity
|
growth/size/body
|
N |
• mice fed normal chow exhibit normal susceptibility to age-associated weight gain and body length
|
homeostasis/metabolism
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Leprtm1.1Chua mutation
(1 available);
any
Lepr mutation
(121 available)
Tg(Agrp-cre)1Gsb mutation
(0 available)
|
|
|
homeostasis/metabolism
liver/biliary system
|
|
• blunting of the increase in liver triglycerides during fasting
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkaa2tm1Vio mutation
(1 available);
any
Prkaa2 mutation
(33 available)
Tg(Agrp-cre)1Gsb mutation
(0 available)
|
|
|
growth/size/body
|
|
• at 3 months of age, mice display a mild decrease in body weight compared to wild-type mice
|
nervous system
|
|
• agouti-related protein expressing neurons are slightly more hyperpolarized than in wild-type mice and do not respond electrophysically to glucose as do wild-type cells
|
behavior/neurological
|
|
• following treatment with melanotan II, mice exhibit less food intake than similarly treated wild-type
|
homeostasis/metabolism
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nhlh2tm2Thbr mutation
(0 available);
any
Nhlh2 mutation
(13 available)
Tg(Agrp-cre)1Gsb mutation
(0 available)
|
|
|
reproductive system
|
N |
• mice exhibit normal uteri weight
|
growth/size/body
|
N |
• mice exhibit normal weight
|
adipose tissue
|
N |
• mice exhibit normal visceral fat depots
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Stat3*A661C*N663C)Sbkv mutation
(1 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(Agrp-cre)1Gsb mutation
(0 available)
|
|
|
growth/size/body
|
|
• mice on a normal chow diet weigh 10% less than littermate controls from weaning until 20 weeks of age
• differences are more pronounced when mice are kept on a high fat diet with mice weighing 15-20% less until the age of 20 weeks
|
homeostasis/metabolism
adipose tissue
|
|
• mice of either sex on a normal chow diet displayed a 30% reduction in epigonodal fat-pad weight at 20 weeks of age
• mice on a high fat diet displayed a 40-60 % weight reduction in the epigonodal fat pads at 20 weeks of age
|
behavior/neurological
|
|
• mice exhibit a slight postpubertal hyperphagia
|
|
|
• at 9 weeks of age, mice exhibit a dramatic increase in basal locomotor activity with a 40% increase during the light phase and 60% during the dark phase compared to control mice
• mice exhibit the highest locomotor activity at the beginning of the dark cycle where they were more than twice as active as their littermate controls
• there are also greater increases in fasting-induced hyperactivity than in control mice
|
Analysis Tools