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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
SryAKR/J
sex-determining region of Chr Y- AKR/J
MGI:3575651
Summary 14 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Map3k4tm1Flv/Map3k4+
X/SryAKR/J
B6.Cg-Map3k4tm1Flv Chr YAKR MGI:4361432
cx2
X/SryAKR/JSryRIII C57BL/6JEi-Chr YAKR-Sxr/EiJ MGI:4839333
cx3
Gadd45gtm1Jni/Gadd45g+
X/SryAKR/J
involves: 129P2/OlaHsd * AKR/J * C57BL/6J MGI:5461496
cx4
Gadd45gtm1Jni/Gadd45g+
X/SryAKR/J
Tg(Map3k4)#Agre/0
involves: 129P2/OlaHsd * AKR/J * C57BL/6J MGI:5461497
cx5
KitlSl-18H/Kitl+
X/SryAKR/J
involves: AKR/J * C57BL/6J MGI:3778817
cx6
X/SryAKR/J
Tht/Tht+
involves: AKR/J * C57BL/6J MGI:3778818
cx7
KitW-42J/KitW-42J
X/SryAKR/J
involves: AKR/J * C57BL/6J MGI:3716809
cx8
KitW-42J/Kit+
X/SryAKR/J
involves: AKR/J * C57BL/6J MGI:3716808
cx9
KitW-v/Kit+
X/SryAKR/J
involves: AKR/J * C57BL/6J MGI:3778813
cx10
KitW-e/Kit+
X/SryAKR/J
involves: AKR/J * C57BL/6J MGI:3778814
cx11
Del(10)1H/+
X/SryAKR/J
involves: AKR/J * C57BL/6J MGI:3778816
cx12
KitW-19H/Kit+
X/SryAKR/J
involves: AKR/J * C57BL/6J MGI:3778792
cx13
KitW-27H/Kit+
X/SryAKR/J
involves: AKR/J * C57BL/6J * CBA/H MGI:3778815
ot14
X/SryAKR/J AKR/J MGI:3716806


Genotype
MGI:4361432
cx1
Allelic
Composition
Map3k4tm1Flv/Map3k4+
X/SryAKR/J
Genetic
Background
B6.Cg-Map3k4tm1Flv Chr YAKR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k4tm1Flv mutation (1 available); any Map3k4 mutation (78 available)
SryAKR/J mutation (6 available); any Sry mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Ovotestis development in Map3k4tm1Flv/Map3k4+ X/SryAKR/J embryos, characterised by gonadal poles (brackets) lacking markers of testis development and expressing markers of ovary development

reproductive system
• at 11 weeks
• in XY gonads

endocrine/exocrine glands
• at 11 weeks




Genotype
MGI:4839333
cx2
Allelic
Composition
X/SryAKR/JSryRIII
Genetic
Background
C57BL/6JEi-Chr YAKR-Sxr/EiJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
SryAKR/J mutation (6 available); any Sry mutation (52 available)
SryRIII mutation (0 available); any Sry mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• Background Sensitivity: The presence of the SxrRIII from the Tp(Y)1Ct transposition results in normal males with normal embryonic testicular development whereas the C57BL/6JEi-Chr Y consomic mice without the additional Sry have delayed testes cord differentiation




Genotype
MGI:5461496
cx3
Allelic
Composition
Gadd45gtm1Jni/Gadd45g+
X/SryAKR/J
Genetic
Background
involves: 129P2/OlaHsd * AKR/J * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gadd45gtm1Jni mutation (0 available); any Gadd45g mutation (10 available)
SryAKR/J mutation (6 available); any Sry mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• severe disruption of testis determination
• about 50% of XY mice develop ovotestes with varying degrees of testicular tissue at E14.5
• about 50% of XY mice develop gonads with ovarian morphology at E14.5

endocrine/exocrine glands
• severe disruption of testis determination




Genotype
MGI:5461497
cx4
Allelic
Composition
Gadd45gtm1Jni/Gadd45g+
X/SryAKR/J
Tg(Map3k4)#Agre/0
Genetic
Background
involves: 129P2/OlaHsd * AKR/J * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gadd45gtm1Jni mutation (0 available); any Gadd45g mutation (10 available)
SryAKR/J mutation (6 available); any Sry mutation (52 available)
Tg(Map3k4)#Agre mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• testis determination and development in XY mice are similar to wild-type XY controls, unlike in mice not carrying the transgene




Genotype
MGI:3778817
cx5
Allelic
Composition
KitlSl-18H/Kitl+
X/SryAKR/J
Genetic
Background
involves: AKR/J * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
KitlSl-18H mutation (1 available); any Kitl mutation (92 available)
SryAKR/J mutation (6 available); any Sry mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• Background Sensitivity: in the presence of SryAKR/J on a C57BL/6 background testes weight is less than normal

reproductive system
• Background Sensitivity: in the presence of SryAKR/J on a C57BL/6 background testes weight is less than normal




Genotype
MGI:3778818
cx6
Allelic
Composition
X/SryAKR/J
Tht/Tht+
Genetic
Background
involves: AKR/J * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
SryAKR/J mutation (6 available); any Sry mutation (52 available)
Tht mutation (2 available); any Tht mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• Background Sensitivity: in the presence of SryAKR/J on a C57BL/6 background testes weight is less than normal

reproductive system
• Background Sensitivity: in the presence of SryAKR/J on a C57BL/6 background testes weight is less than normal




Genotype
MGI:3716809
cx7
Allelic
Composition
KitW-42J/KitW-42J
X/SryAKR/J
Genetic
Background
involves: AKR/J * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
KitW-42J mutation (1 available); any Kit mutation (181 available)
SryAKR/J mutation (6 available); any Sry mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

reproductive system
• 1 male with bilateral testes was born that had minor internal genitalia abnormalities including: right testis is smaller than left, right epididymis' cauda was not completely formed and the average length of the testes was smaller relative to wild-type




Genotype
MGI:3716808
cx8
Allelic
Composition
KitW-42J/Kit+
X/SryAKR/J
Genetic
Background
involves: AKR/J * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
KitW-42J mutation (1 available); any Kit mutation (181 available)
SryAKR/J mutation (6 available); any Sry mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• males have right testis smaller than the left, especially when the alleles are inherited from the mother
• one hermaphrodite was found with a left testicular gonad and a contralateral putative ovotestis that was associated with both Mullerian and Wolffian duct derivatives

endocrine/exocrine glands
• males have right testis smaller than the left, especially when the alleles are inherited from the mother




Genotype
MGI:3778813
cx9
Allelic
Composition
KitW-v/Kit+
X/SryAKR/J
Genetic
Background
involves: AKR/J * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
KitW-v mutation (10 available); any Kit mutation (181 available)
SryAKR/J mutation (6 available); any Sry mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• Background Sensitivity: in the presence of SryAKR/J on a C57BL/6 background testes weight is less than normal

reproductive system
• Background Sensitivity: in the presence of SryAKR/J on a C57BL/6 background testes weight is less than normal




Genotype
MGI:3778814
cx10
Allelic
Composition
KitW-e/Kit+
X/SryAKR/J
Genetic
Background
involves: AKR/J * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
KitW-e mutation (2 available); any Kit mutation (181 available)
SryAKR/J mutation (6 available); any Sry mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• Background Sensitivity: in the presence of SryAKR/J on a C57BL/6 background testes weight is less than normal

reproductive system
• Background Sensitivity: in the presence of SryAKR/J on a C57BL/6 background testes weight is less than normal




Genotype
MGI:3778816
cx11
Allelic
Composition
Del(10)1H/+
X/SryAKR/J
Genetic
Background
involves: AKR/J * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(10)1H mutation (0 available); any Del(10)1H mutation (0 available)
SryAKR/J mutation (6 available); any Sry mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• Background Sensitivity: in the presence of SryAKR/J on a C57BL/6 background testes weight is less than normal

reproductive system
• Background Sensitivity: in the presence of SryAKR/J on a C57BL/6 background testes weight is less than normal




Genotype
MGI:3778792
cx12
Allelic
Composition
KitW-19H/Kit+
X/SryAKR/J
Genetic
Background
involves: AKR/J * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
KitW-19H mutation (1 available); any Kit mutation (181 available)
SryAKR/J mutation (6 available); any Sry mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• Background Sensitivity: hermaphroditism is found within two generations of backcrossing to C57BL/6 and by the third generation completely sex reversed, sterile XY females are found; the frequency of this sex reversal increases with further backcrossing to C57BL/6

endocrine/exocrine glands




Genotype
MGI:3778815
cx13
Allelic
Composition
KitW-27H/Kit+
X/SryAKR/J
Genetic
Background
involves: AKR/J * C57BL/6J * CBA/H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
KitW-27H mutation (0 available); any Kit mutation (181 available)
SryAKR/J mutation (6 available); any Sry mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• Background Sensitivity: in the presence of SryAKR/J on a C57BL/6 background testes weight is less than normal

reproductive system
• Background Sensitivity: in the presence of SryAKR/J on a C57BL/6 background testes weight is less than normal




Genotype
MGI:3716806
ot14
Allelic
Composition
X/SryAKR/J
Genetic
Background
AKR/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
SryAKR/J mutation (6 available); any Sry mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• despite previous reports, no sex reversal is observed





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last database update
07/05/2024
MGI 6.24
The Jackson Laboratory