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Targeted Allele Detail
Symbol: Gadd45gtm1Jni
Name: growth arrest and DNA-damage-inducible 45 gamma; targeted mutation 1, James N Ihle
MGI ID: MGI:2182734
Synonyms: Gadd45gamma-deficient
Gene: Gadd45g  Location: Chr13:52000714-52002504 bp, + strand  Genetic Position: Chr13, 26.36 cM, cytoband A5-B
Alliance: Gadd45gtm1Jni page
Germline Transmission:  Earliest citation of germline transmission: J:68832
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsMost of the coding sequence of the gene (from part of exon 1 through part of exon 4) was replaced with a neomycin resistance cassette. Absence of gene expression in Il2-activated T cells from homozygous mutant animals was confirmed by Northern blot analysis using a probe to the coding region of the gene. (J:68832)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gadd45g Mutation:  8 strains or lines available
Original:  J:68832 Hoffmeyer A, et al., Gadd45gamma is dispensable for normal mouse development and T-cell proliferation. Mol Cell Biol. 2001 May;21(9):3137-43
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.13
The Jackson Laboratory