Gadd45gtm1Jni
Targeted Allele Detail
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Symbol: |
Gadd45gtm1Jni |
Name: |
growth arrest and DNA-damage-inducible 45 gamma; targeted mutation 1, James N Ihle |
MGI ID: |
MGI:2182734 |
Synonyms: |
Gadd45gamma-deficient |
Gene: |
Gadd45g Location: Chr13:52000714-52002504 bp, + strand Genetic Position: Chr13, 26.36 cM, cytoband A5-B
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Alliance: |
Gadd45gtm1Jni page
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Germline Transmission: |
Earliest citation of germline transmission:
J:68832
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Parent Cell Line: |
E14 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Most of the coding sequence of the gene (from part of exon 1 through part of exon 4) was replaced with a neomycin resistance cassette. Absence of gene expression in Il2-activated T cells from homozygous mutant animals was confirmed by Northern blot analysis using a probe to the coding region of the gene.
(J:68832)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Gadd45g Mutation: |
8 strains or lines available
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Original: |
J:68832 Hoffmeyer A, et al., Gadd45gamma is dispensable for normal mouse development and T-cell proliferation. Mol Cell Biol. 2001 May;21(9):3137-43 |
All: |
4 reference(s) |
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