All Phenotypes Prkdc<dxnph> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Prkdc^dxnph
doxorubicin nephropathy
MGI:3574427

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prkdc^dxnph/Prkdc^dxnph	129X1/SvJ	MGI:3574781
hm2	Prkdc^dxnph/Prkdc^dxnph	BALB/c	MGI:2663730
hm3	Prkdc^dxnph/Prkdc^dxnph	BALB/cJ	MGI:3574780
hm4	Prkdc^dxnph/Prkdc^dxnph	involves: BALB/cJ * 129X1/SvJ	MGI:3574895
cx5	Apc^Min/Apc⁺ Pla2g2a^Mom1-r/? Prkdc^dxnph/Prkdc^dxnph	involves: BALB/cByJ * C57BL/6	MGI:4461429
cx6	Dxmod/Dxmod Prkdc^dxnph/Prkdc^dxnph	involves: BALB/cJ * 129X1/SvJ	MGI:3574896

Allelic Composition	Prkdc^dxnph/Prkdc^dxnph
Genetic Background	129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkdc^dxnph mutation (0 available); any Prkdc mutation (408 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased urine protein level ( J:96632 )

• onset of proteinuria about 5 days after DOX injection

increased physiological sensitivity to xenobiotic ( J:96632 )

• severe susceptibility to doxorubicin (DOX) nephropathy

renal/urinary system

increased urine protein level ( J:96632 )

• onset of proteinuria about 5 days after DOX injection

abnormal kidney morphology ( J:96632 )

• severe susceptibility to doxorubicin (DOX) nephropathy

glomerulosclerosis ( J:96632 )

• progress to significant glomerulosclerosis within 14 days of DOX injections

Allelic Composition	Prkdc^dxnph/Prkdc^dxnph
Genetic Background	BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkdc^dxnph mutation (0 available); any Prkdc mutation (408 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased cellular sensitivity to gamma-irradiation ( J:68487 )

• increased sensitivity to gamma irradition of mammary cells

Allelic Composition	Prkdc^dxnph/Prkdc^dxnph
Genetic Background	BALB/cJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkdc^dxnph mutation (0 available); any Prkdc mutation (408 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased urine protein level ( J:96632 )

• onset of proteinuria about 5 days after DOX injection

increased physiological sensitivity to xenobiotic ( J:96632 )

• severe susceptibility to doxorubicin (DOX) nephropathy

renal/urinary system

increased urine protein level ( J:96632 )

• onset of proteinuria about 5 days after DOX injection

abnormal kidney morphology ( J:96632 )

• severe susceptibility to doxorubicin (DOX) nephropathy

glomerulosclerosis ( J:96632 )

• progress to significant glomerulosclerosis within 14 days of DOX injections

Allelic Composition	Prkdc^dxnph/Prkdc^dxnph
Genetic Background	involves: BALB/cJ * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkdc^dxnph mutation (0 available); any Prkdc mutation (408 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased urine protein level ( J:96632 )

• susceptibility to doxorubicin-induced proteinuria

renal/urinary system

increased urine protein level ( J:96632 )

• susceptibility to doxorubicin-induced proteinuria

glomerulosclerosis ( J:96632 )

• susceptibility to doxorubicin-induced glomerulosclerosis

Allelic Composition	Apc^Min/Apc⁺ Pla2g2a^Mom1-r/? Prkdc^dxnph/Prkdc^dxnph
Genetic Background	involves: BALB/cByJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (154 available)
Pla2g2a^Mom1-r mutation (0 available); any Pla2g2a mutation (7 available)
Prkdc^dxnph mutation (0 available); any Prkdc mutation (408 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased incidence of tumors by ionizing radiation induction ( J:83497 )

• mice show 2-3 fold increase in adenoma incidence in the small intestine after X-irradiation

Allelic Composition	Dxmod/Dxmod Prkdc^dxnph/Prkdc^dxnph
Genetic Background	involves: BALB/cJ * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dxmod mutation (0 available); any Dxmod mutation (0 available)
Prkdc^dxnph mutation (0 available); any Prkdc mutation (408 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

glomerulosclerosis ( J:96632 )

• susceptibility to doxorubicin-induced glomerulosclerosis

dilated renal tubule ( J:96632 )

• susceptibility to doxorubicin-induced microcystic tubular dilations

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23