Phenotypes associated with this allele

• Allele Symbol: Kcnt1⁺
• Allele Name: wild type
• Allele ID: MGI:3573748
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Kcnt1^tm1.2Clin/Kcnt1^+	B6.Cg-Kcnt1^tm1.2Clin	MGI:5908188
ht2	Kcnt1^em1Lekk/Kcnt1^+	C57BL/6J-Kcnt1^em1Lekk	MGI:7624379
ht3	Kcnt1^em1Pqt/Kcnt1^+	C57BL/6J-Kcnt1^em1Pqt	MGI:7442319

Genotype
MGI:5908188

ht1

• Allelic Composition: Kcnt1^tm1.2Clin/Kcnt1⁺
• Genetic Background: B6.Cg-Kcnt1^tm1.2Clin

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

increased pruritus ( J:228059 )

• chloroquine, histamine or compound 48-80 elicit a robust enhancement of scratching behavior in the first 5 min after injection

Genotype
MGI:7624379

ht2

• Allelic Composition: Kcnt1^em1Lekk/Kcnt1⁺
• Genetic Background: C57BL/6J-Kcnt1^em1Lekk

behavior/neurological

behavior/neurological phenotype ( J:287751 )

N • normal behavior in open field test

seizures ( J:287751 )

• spontaneous electrographic seizures and persistent interictal spikes

increased susceptibility to pharmacologically induced seizures ( J:287751 )

• convulsive (phase 3) seizures after PTZ administration

nervous system

seizures ( J:287751 )

• spontaneous electrographic seizures and persistent interictal spikes

increased susceptibility to pharmacologically induced seizures ( J:287751 )

• convulsive (phase 3) seizures after PTZ administration

mortality/aging

mortality/aging ( J:287751 )

N • normal survival

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
developmental and epileptic encephalopathy 14		DOID:0080439	OMIM:614959	J:287751

Genotype
MGI:7442319

ht3

• Allelic Composition: Kcnt1^em1Pqt/Kcnt1⁺
• Genetic Background: C57BL/6J-Kcnt1^em1Pqt

behavior/neurological

behavior/neurological phenotype ( J:333512 )

N • mice exhibit no evidence of epileptic or behavioral phenotypes and no increased susceptibility to chemically or thermally induced seizures

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	developmental and epileptic encephalopathy 14	DOID:0080439	OMIM:614959	J:333512