Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr3c1tm2Ljm mutation
(0 available);
any
Nr3c1 mutation
(34 available)
Tg(Camk2a-cre)T50Stl mutation
(0 available)
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homeostasis/metabolism
behavior/neurological
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• in forced swim and tail suspension tests mice exhibit a decrease in activity indicative of despair
• however, despair behaviors are reversed by chronic treatment with the tricyclic antidepressant imipramine
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• in forced swim and tail suspension tests mice exhibit a decrease in activity indicative of despair
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nervous system
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• low-frequency stimulation in the presence of 1um corticosterone of hippocampal slices can not induce long term depression (LTD)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fostm1Mxu mutation
(1 available);
any
Fos mutation
(42 available)
Tg(Camk2a-cre)T50Stl mutation
(0 available)
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nervous system
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• population spike amplitude evoked by minimal stimulation intensity is significantly larger in hippocampal mutant slices compared to wild-type slices with a large increase in cellular excitability and a larger maximal response
• >60% of slices show epileptiform activity following low intensity stimulation compared to <40% of wild-type
• very low concentration kainic acid (KA) stimulation of hippocampal slices produces maximal CA3 population spike amplitude and higher concentrations induces severe epileptiform activity, reducing amplitude of the population response
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Hwu mutation
(16 available);
any
Pten mutation
(81 available)
Tg(Camk2a-cre)T50Stl mutation
(0 available)
Tg(Thy1-EGFP)MJrs mutation
(1 available)
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nervous system
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• increase in brain size due to expansion of allocortex and neocortex
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• apical dendrites of pyramidal neurons in cortical layer 2/3 but not layer 5 are longer and more tortuous than in controls
• total arbor length is on average 1.6 mm longer in mutants, indicating an approximate 80% expansion of the apical dendritic tree
• however, basal dendritic length is not different
• rapamycin treatments completely prevent dendritic growth seen following Pten deletion
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabrg2tm2Lusc mutation
(1 available);
any
Gabrg2 mutation
(41 available)
Tg(Camk2a-cre)T50Stl mutation
(0 available)
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mortality/aging
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• mice die around 7 weeks of age
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnftm1Limm mutation
(0 available);
any
Bdnf mutation
(39 available)
Tg(Camk2a-cre)T50Stl mutation
(0 available)
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behavior/neurological
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• female, but not male, mice exhibit reduced preference for a natural reward in sucrose preference tests compared to wild-type mice
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• female, but not male, mice exhibit more immobility when placed in swim test than wild-type mice
• unlike wild-type mice, female and male mice do not exhibit any decrease in immobility following administration of desipramine
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• male, but not female, mice exhibit increased locomotor activity compared to same sex wild-type mice
• however, activity levels are normal after 4 days of habituation
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Analysis Tools