Nr3c1^tm2Ljm
Targeted Allele Detail

Summary

• Symbol: Nr3c1^tm2Ljm
• Name: nuclear receptor subfamily 3, group C, member 1; targeted mutation 2, Louis J Muglia
• MGI ID: MGI:3575536
• Synonyms: GRf^lox, GrloxPneo, Nr3c1^flox
• Gene: Nr3c1 Location: Chr18:39543598-39652474 bp, - strand Genetic Position: Chr18, 21.09 cM
• Alliance: Nr3c1^tm2Ljm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97484
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• A loxP site was inserted upstream of exon 1C and a floxed PGK-neo was inserted into intron 2. (J:97484)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr3c1 Mutation: 34 strains or lines available

References

• Original: J:97484 Brewer JA, et al., T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation. Nat Med. 2003 Oct;9(10):1318-22
• All: 16 reference(s)