All Phenotypes Suz12<Gt(Betageo)1Khe> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Suz12^{Gt(Betageo)1Khe}
gene trap 1, Kristian Helin
MGI:3530650

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Suz12^{Gt(Betageo)1Khe}/Suz12^{Gt(Betageo)1Khe}	involves: 129P2/OlaHsd * C57BL/6	MGI:3531205
ht2	Suz12^{Gt(Betageo)1Khe}/Suz12⁺	involves: 129P2/OlaHsd	MGI:5699869
ht3	Suz12^{Gt(Betageo)1Khe}/Suz12^Plt8	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6	MGI:3796625
cx4	Mpl^tm1Wsa/Mpl^tm1Wsa Suz12^{Gt(Betageo)1Khe}/Suz12⁺	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6	MGI:3796626
cx5	Nf1^tm1Tyj/Nf1⁺ Suz12^{Gt(Betageo)1Khe}/Suz12⁺ Trp53^tm1Tyj/Trp53⁺	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	MGI:5699874
cx6	Nf1^tm1Tyj/Nf1⁺ Suz12^{Gt(Betageo)1Khe}/Suz12⁺	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	MGI:5699877

Allelic Composition	Suz12^{Gt(Betageo)1Khe}/Suz12^{Gt(Betageo)1Khe}
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Suz12^{Gt(Betageo)1Khe} mutation (1 available); any Suz12 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:93307 )

• die during early postimplantation stages, with nearly complete reabsorption of embryos at E10.5 and much smaller embryos at E8.5

cellular

increased embryonic tissue cell apoptosis ( J:93307 )

• large number of cells in E7.5 embryos underwent cell death

decreased cell proliferation ( J:93307 )

• E7.5 and E8.5 embryonic cells fail to proliferate

embryo

increased embryonic tissue cell apoptosis ( J:93307 )

• large number of cells in E7.5 embryos underwent cell death

abnormal developmental patterning ( J:93307 )

• difficult to determine the distinction between the three embryonic sheets

embryonic growth arrest ( J:93307 )

• developmental block at around E7.5

decreased embryo size ( J:93307 )

• E7.5 and E8.5 homozygous embryos were severely reduced in size with the E8.5 embryos resembling E7.5 embryos

abnormal embryonic neuroepithelium morphology ( J:93307 )

• the neural ectoderm does not develop, resulting in the complete absence of organogenesis

abnormal extraembryonic tissue morphology ( J:93307 )

abnormal amnion morphology ( J:93307 )

• amnion was indistinguishable at E7.5

abnormal amniotic cavity morphology ( J:93307 )

• the amniotic cavity does not form correctly

• the amniotic cavity did not fold around the E8.5 embryo

abnormal chorion morphology ( J:93307 )

• chorion was indistinguishable at E7.5 and did not extend around the embryo at E8.5

abnormal ectoplacental cavity morphology ( J:93307 )

• the ectoplacental cavity does not form correctly and vacuolated cells were found in the region of the ectoplacental cavity

abnormal extraembryonic coelom morphology ( J:93307 )

• the exocoelomic cavity does not form correctly

growth/size/body

decreased embryo size ( J:93307 )

• E7.5 and E8.5 homozygous embryos were severely reduced in size with the E8.5 embryos resembling E7.5 embryos

nervous system

abnormal embryonic neuroepithelium morphology ( J:93307 )

• the neural ectoderm does not develop, resulting in the complete absence of organogenesis

Allelic Composition	Suz12^{Gt(Betageo)1Khe}/Suz12⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Suz12^{Gt(Betageo)1Khe} mutation (1 available); any Suz12 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased histiocytic sarcoma incidence ( J:217077 )

• 20% of mice develop histiocytic sarcoma

Allelic Composition	Suz12^{Gt(Betageo)1Khe}/Suz12^Plt8
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Suz12^{Gt(Betageo)1Khe} mutation (1 available); any Suz12 mutation (60 available)
Suz12^Plt8 mutation (0 available); any Suz12 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:136262 )

• no compound heterozygous animals were identified at weaning, indicating prenatal lethality

Allelic Composition	Mpl^tm1Wsa/Mpl^tm1Wsa Suz12^{Gt(Betageo)1Khe}/Suz12⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mpl^tm1Wsa mutation (1 available); any Mpl mutation (46 available)
Suz12^{Gt(Betageo)1Khe} mutation (1 available); any Suz12 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal thrombopoiesis ( J:136262 )

• amelioration of thrombocytopenia compared to Mpl^tm1Wsa , increased platelet cell number was significant but not to the wild-type level

thrombocytopenia ( J:136262 )

• thrombocytopenia of Mpl^tm1Wsa ameliorated, however platelet count is significantly lower than normal wild-type level

increased leukocyte cell number ( J:136262 )

increased lymphocyte cell number ( J:136262 )

immune system

abnormal thrombopoiesis ( J:136262 )

• amelioration of thrombocytopenia compared to Mpl^tm1Wsa , increased platelet cell number was significant but not to the wild-type level

increased leukocyte cell number ( J:136262 )

increased lymphocyte cell number ( J:136262 )

Allelic Composition	Nf1^tm1Tyj/Nf1⁺ Suz12^{Gt(Betageo)1Khe}/Suz12⁺ Trp53^tm1Tyj/Trp53⁺
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf1^tm1Tyj mutation (3 available); any Nf1 mutation (157 available)
Suz12^{Gt(Betageo)1Khe} mutation (1 available); any Suz12 mutation (60 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:217077 )

• mice die by 150 days

neoplasm

increased tumor incidence ( J:217077 )

increased lymphoma incidence ( J:217077 )

• 12% of mice develop lymphomas

increased histiocytic sarcoma incidence ( J:217077 )

• 62% of mice develop histiocytic sarcomas

increased neurofibrosarcoma incidence ( J:217077 )

• 38% of mice develop malignant peripheral nerve sheath tumors

• tumors develop on average at 2.3 months of age

increased hemangiosarcoma incidence ( J:217077 )

• 4% of develop angiosarcomas

increased glioma incidence ( J:217077 )

• 54% of mice develop high-grade gliomas

• gliomas develop on average at 3 months of age

nervous system

increased neurofibrosarcoma incidence ( J:217077 )

• 38% of mice develop malignant peripheral nerve sheath tumors

• tumors develop on average at 2.3 months of age

increased glioma incidence ( J:217077 )

• 54% of mice develop high-grade gliomas

• gliomas develop on average at 3 months of age

Allelic Composition	Nf1^tm1Tyj/Nf1⁺ Suz12^{Gt(Betageo)1Khe}/Suz12⁺
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal melanocyte morphology ( J:217077 )

• 9% of mice develop melanocytic nevi

mortality/aging

premature death ( J:217077 )

• 80% of mice die by 400 days

neoplasm

increased tumor incidence ( J:217077 )

• 9% of mice develop melanocytic nevi

increased intestinal adenoma incidence ( J:217077 )

• 10% of mice develop intestinal adenomas

increased hepatocellular carcinoma incidence ( J:217077 )

• 3% of mice develop hepatocellular carcinoma

increased neurofibroma incidence ( J:217077 )

• 3% of mice develop neurofibromas

increased lymphoma incidence ( J:217077 )

• 23% of mice develop lymphoma

increased histiocytic sarcoma incidence ( J:217077 )

• 32% of mice develop histiocytic sarcoma

increased neurofibrosarcoma incidence ( J:217077 )

increased Schwannoma incidence ( J:217077 )

• 3% of mice develop schwannomas

nervous system

increased neurofibroma incidence ( J:217077 )

• 3% of mice develop neurofibromas

increased neurofibrosarcoma incidence ( J:217077 )

increased Schwannoma incidence ( J:217077 )

• 3% of mice develop schwannomas

digestive/alimentary system

increased intestinal adenoma incidence ( J:217077 )

• 10% of mice develop intestinal adenomas

liver/biliary system

increased hepatocellular carcinoma incidence ( J:217077 )

• 3% of mice develop hepatocellular carcinoma

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