Analysis Tools
homeostasis/metabolism
| N |
• mice exhibit normal cAMP- and cGMP-activated CFTR transepithelial short circuit currents in response to forskolin and 8-Br-cGMP
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Allele Symbol Allele Name Allele ID |
Nherf2Gt(OST2298)Lex gene trap OST2298, Lexicon Genetics MGI:3530645 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal cAMP- and cGMP-activated CFTR transepithelial short circuit currents in response to forskolin and 8-Br-cGMP
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• when activated with glucose, cAMP- and cGMP-activated CFTR transepithelial short circuit currents are increased 25% compared to wild-type mice
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• when activated with forskolin, cAMP- and cGMP-activated CFTR transepithelial short circuit currents are decrease 37% compared to wild-type mice
• when activated with 8-Br-cGMP, cAMP- and cGMP-activated CFTR transepithelial short circuit currents are decrease 34% compared to wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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