Phenotypes associated with this allele

• Allele Symbol: Nherf2^{Gt(OST2298)Lex}
• Allele Name: gene trap OST2298, Lexicon Genetics
• Allele ID: MGI:3530645
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nherf2^Gt(OST2298)Lex/Nherf2^Gt(OST2298)Lex	FVB.129-Nherf2^Gt(OST2298)Lex	MGI:3769358
cx2	Nherf1^tm1Ssl/Nherf1^tm1Ssl Nherf2^Gt(OST2298)Lex/Nherf2^Gt(OST2298)Lex	involves: 129S1/Sv * 129S5/SvEvBrd * 129X1/SvJ * FVB/N	MGI:3769359

Genotype
MGI:3769358

hm1

• Allelic Composition: Nherf2^{Gt(OST2298)Lex}/Nherf2^{Gt(OST2298)Lex}
• Genetic Background: FVB.129-Nherf2^{Gt(OST2298)Lex}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:128912 )

N • mice exhibit normal cAMP- and cGMP-activated CFTR transepithelial short circuit currents in response to forskolin and 8-Br-cGMP

Genotype
MGI:3769359

cx2

• Allelic Composition: Nherf1^tm1Ssl/Nherf1^tm1Ssl; Nherf2^{Gt(OST2298)Lex}/Nherf2^{Gt(OST2298)Lex}
• Genetic Background: involves: 129S1/Sv * 129S5/SvEvBrd * 129X1/SvJ * FVB/N

homeostasis/metabolism

abnormal response/metabolism to endogenous compounds ( J:128912 )

• when activated with glucose, cAMP- and cGMP-activated CFTR transepithelial short circuit currents are increased 25% compared to wild-type mice

abnormal physiological response to xenobiotic ( J:128912 )

• when activated with forskolin, cAMP- and cGMP-activated CFTR transepithelial short circuit currents are decrease 37% compared to wild-type mice

• when activated with 8-Br-cGMP, cAMP- and cGMP-activated CFTR transepithelial short circuit currents are decrease 34% compared to wild-type mice