Nherf1^tm1Ssl
Targeted Allele Detail

Summary

• Symbol: Nherf1^tm1Ssl
• Name: NHERF family PDZ scaffold protein 1; targeted mutation 1, Shirish Shenolikar
• MGI ID: MGI:2386785
• Synonyms: Nherf1^-, NHERF-1(-), NHERF1-
• Gene: Nherf1 Location: Chr11:115054167-115072007 bp, + strand Genetic Position: Chr11, 80.65 cM, cytoband E2
• Alliance: Nherf1^tm1Ssl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78606
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced by a neomycin selection cassette inserted by homologous recombination. Protein was undetected in homozygous mutant mice by Western blot analysis of kidney extracts and immunostaining of proximal renal tubules. (J:78606)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nherf1 Mutation: 17 strains or lines available

References

• Original: J:78606 Shenolikar S, et al., Targeted disruption of the mouse NHERF-1 gene promotes internalization of proximal tubule sodium-phosphate cotransporter type IIa and renal phosphate wasting. Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11470-5
• All: 26 reference(s)