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Allele Symbol Allele Name Allele ID |
Magi1Gt(OST33326)Lex gene trap OST33326, Lexicon Genetics MGI:3530498 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no activation in isolated mouse lung endothelial cells (MLECs) after exposure to inflammatory conditions
• disturbed blood flow induced p90RSK activation was unaffected
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• lung endothelial cells exposed to disturbed blood flow and laminar blood flow showed less activation evidenced by markedly decreased anti-VCAM-1 staining
• Body size and weight, development, life span, and organ structures at the gross anatomic levelife span, and organ structures at the gross anatomic level are indistinguishable compaired to the control mice.
• blood pressure was normotensive
• normal plasma IL-6 level
• the inflammatory response of isolated peripheral blood mononuclear cells (PBMCs), bone marrow-derived macrophages (BMDMs), splenocytes, and vascular smooth muscle cells (VSMCs) were nomal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• four weeks after partial ligation of a left carotid artery (LCA), intimal thickening was inhibited
• macrophase infiltration, a hallmark of vascular inflammation and atherosclerosis, was downregulated
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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