Magi1^{Gt(OST33326)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Magi1^{Gt(OST33326)Lex}
• Name: membrane associated guanylate kinase, WW and PDZ domain containing 1; gene trap OST33326, Lexicon Genetics
• MGI ID: MGI:3530498
• Synonyms: Magi1^{Gt(Betageo)475Lex}
• Gene: Magi1 Location: Chr6:93652436-94260898 bp, - strand Genetic Position: Chr6, 42.7 cM, cytoband D3
• Alliance: Magi1^{Gt(OST33326)Lex} page

Mutation origin

• Mutant Cell Line: OST33326
• Germline Transmission: Earliest citation of germline transmission: J:278456
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: A gene trap vecotr inserted into the first and second exon of the gene resulting in splicing out most of the first intron and inserting a STOP codon at the end of the first exon, and eliminates the full length transcript. Lack of protein expression was confrimed by immunoblot analysis on tissue lysates obtained from mutant and control mice. (J:278456)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST33326	CG494435 ; (MGI Seq Detail)	3' RACE	Chr6:93918960-93920284 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  81 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Magi1 Mutation: 174 strains or lines available

References

• Original: J:278456 Abe JI, et al., MAGI1 as a link between endothelial activation and ER stress drives atherosclerosis. JCI Insight. 2019 Apr 4;4(7)
• All: 3 reference(s)